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BACKGROUND AND AIM: Associations between genetic polymorphisms of CYP1A1 MspⅠor GSTT1 among residents from an electronic waste recycling site in China, and the frequencies of micronucleated binucleated cells in peripheral blood lymphocytes were investigated.

背景与目的:探讨代谢酶CYP1A1 Msp Ⅰ位点和GSTT1基因多态性与电子垃圾处理区居民外周血双核淋巴细胞微核率的关系。

Levels of lead, cadmium and copper in blood and urine were determined by atomic absorption spectroscopy, and frequencies of micronucleated binucleated cells in peripheral blood lymphocyte were measured by cytokinesis-blocked micronucleus assay.

采用石墨炉原子吸收光谱法检测血铅、血镉和尿铅、尿镉、尿铜含量,火焰原子吸收光谱法测定血清铜含量;胞质阻滞双微核实验测定淋巴细胞双微核率。

Associations between Gene Polymorphisms of CYP1A1, GSTT1 and Frequencies of MNed Binucleated Cells in Residents from an E-waste Dismantling Site

CEPS 思博网--文章书目;-1页数:5 需求点数:20 电子全文:请登入。篇名 CYP1A1, GSTT1基因多态性与电子垃圾处理区居民双核淋巴细胞微核率的关系

The micronucleus test has shown that cystamine has evident radioprotective effect at chromosome damage of blood lymphocyties and nucleated bone-marrow cells in irradiation rats. The Dose-Reduction Factor is 1.89 and 1.81 respectively.

微核测定法证明,胱胺对受照射大鼠的血液淋巴细胞和骨髓有核细胞染色体的辐射损伤有明显的保护作用,其剂量减低系数分别为1.89和1.81。

Genotoxicity of ethylicin and bismerthiazol on Vicia faba root tip cells was studied.

利用蚕豆根尖微核技术研究农药乙蒜素和细菌溴腈对蚕豆根尖细胞的遗传损伤,测定蚕豆根尖细胞的微核率、有丝分裂指数和染色体畸变率。

Results showed that DCF with different dosages could increase the frequency of micronucleated erythrocytes markedly,except the first injection of the dosage with 5 and 10 mg/kg,every group caused an increase in the frequency of nuclear abnormality erythrocytes,the effects in cell membrane and cytoplasm were less than the effects in karyon by DCF,and the most toxicity was exhibited after the second injection.

结果表明,注射DCF后所有剂量组均能引起中华蟾蜍红细胞微核细胞率显著升高;除5,10mg/kg剂量组在第1次注射后较对照组低外,其他注射剂量和次数均引起核异常细胞率升高,DCF对细胞膜与细胞质的影响小于其对细胞核的影响,在4次注射中以第2次注射后对红细胞的毒性效应最大。

METHODS:The micronucleus test of Vicia faba root tip cell was used to detect the water quality,and to survey the chemical oxygen demand.The micronuclear rates and Pollution Index were determined and the F-test was used to evaluate the difference in micronuclear rates among different samples.

材料与方法:用蚕豆根尖细胞微核技术对各采样点水样进行监测,并对各水样进行化学需氧量(chemical oxygen demand,CODcr)的测定,统计分析各采样点水样的蚕豆根尖细胞微核千分率及污染指数。

The micronuclear frequencies of fetal liver blood were 2.67, 3.33 and 4‰ in treatment group, given intraperitoneally combined NET-OEN at doses of 10, 50 and 100mg/kg, respectively. However, the micronuclear frequencies of bone marrow erythroblasts and fetal liver blood in control group were 1.8~3‰.

作者采用微核试验观察了复方庚炔诺酮对小鼠活体骨髓多染性红细胞及胎肝血微核率的影响,检测其有无潜在的致突变作用,从而为评价复方庚炔诺酮的安全性提供依据。

Methods Through comet assay and observing mutation frequency of HPRT gene, frequencies of micronuclei and multinucleate cells, chromosome analysis, we researched the hereditary toxicity of DU and protection of DMSO.

采用彗星实验、HPRT基因突变检测、微核多核及染色体分析研究贫铀的遗传毒性作用及DMSO对其毒性的抑制作用。

One of the minute, hooked projections extending from and interlocking the barbules of a feather.

小核,微核原生动物纤毛虫类体内两个细胞核中较小的一个,其中含有基因材料和繁殖功能

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