得接近

When we have moksha, we believe that we become closer to god.

当我们已经解脱，我们相信我们会变得更接近神。

Any moraceous tree of the tropical genus Ficus; produces a closed pear-shaped receptacle that becomes fleshy and edible when mature.

热带榕属桑科树的任意一种，；产一种接近梨型的花托，成熟时变得肉厚，可食用。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

In 2000 approximately 101 million Americans lived in areas that did not meet at least one of the standards for criteria air pollutants.38 As of September 2000 there were a total of 114 nonattainment areas.39 The map in Figure 5-7 shows these nonattainment areas.

在2000年接近10100万美国人生活在连一条关于空气污染物标准都未达到的地区。到2000年九月，总计有114个未达标地区。当一得去每日平均每小时的词浓度超过国家空气质量标准时，该地区被定一位未达标为达标地区。图5-7的地图显示了这些未达标地区。

Based on relative literatures,this part has included five resesearch aspects as below.1 Fifteen compounds were isolated and purified by extraction,column chromatography,and their structures were determined on the basis of spectral analysis: acteoside(Ⅰ-1),isoacteoside(Ⅰ-2),crenatoside(Ⅰ-3),cistanoside F(Ⅰ-4),sinapoyl-4-O-β-D-glucoside(Ⅰ-5),adenosine(Ⅰ-6),β-siterol(Ⅰ-7),oleanic acid(Ⅰ-8), succinic acid(Ⅰ-9),caffeic acid(Ⅰ-10),protocatechuic aldehyde(Ⅰ-11),p-hydro xybenzyl alcohol(Ⅰ-12),β-daucosterol(Ⅰ-13),D-galacitol(Ⅰ-14),D-mannitol(Ⅰ-15).Ⅰ-4～15 were obtained from this plant for the first time,andⅠ-6,7,9,and 13 were isolated from Orobanche genus for the first time.2 The scavenging test of DPPH showed that most compounds have comparative antioxidant activity as L-ascorbic acid and part of them show better activity such as the O.coerulescens extract and phenylethanoid glycosides.Acteoside showed potent free radical scavenging effects with a median inhibition concentration of 25.6μg/ml.3 The anti-HBV activities of acteoside,isoacteoside and crenatoside were measured,and all of them showed suppressive activity on the expression of HBsAg and HBeAg in the HepG2.2.15 cell line.

本论文在文献调研基础上对紫花列当化学成分及生物活性进行了研究，并从免疫抗病毒角度探讨紫花列当中特征性成分类叶升麻苷的肝保护作用及其机制。1采用大孔树脂、硅胶和Sephadex LH-20等色谱技术对紫花列当进行系统的植物化学研究，从中分离得到19个化合物，利用UV和NMR等波谱手段及理化性质鉴定了其中的15个化合物，分别为类叶升麻苷(Ⅰ-1)、异类叶升麻苷(Ⅰ-2)、crenatoside(Ⅰ-3)、cistanoside F(Ⅰ-4)、sinapoyl-4-O-β-D-glucoside(Ⅰ-5)、腺苷(Ⅰ-6)、β-谷甾醇(Ⅰ-7)、齐墩果酸(Ⅰ-8)、琥珀酸(Ⅰ-9)、咖啡酸(Ⅰ-10)、原儿茶醛(Ⅰ-11)、对羟甲基苯甲酸(Ⅰ-12)、β-胡萝卜苷(Ⅰ-13)、D-半乳糖醇(Ⅰ-14)和甘露醇(Ⅰ-15除化合物Ⅰ-1、Ⅰ-2和Ⅰ-3外，其余化合物均为首次从该植物中分离得到。2)通过大孔树脂富集该药材有效部位苯乙醇总苷，并采用HPLC测得其所含特征性成分类叶升麻苷的含量可达80%以上。3DPPH自由基清除试验显示紫花列当提取物及其所含的苯乙醇苷类化合物均具有较好的抗氧化能力，其清除DPPH自由基能力接近于抗坏血酸。4采用卡介苗整体致敏、脂多糖离体攻击构建大鼠原代肝细胞免疫性损伤模型，在体外观察类叶升麻苷的保肝作用。

Matrox, with its Parhelia almost seven years ago, XGI with its Volari, and 3DLabs with its Realizm all threw in the towel, and with good reason--modern GPUs are extremely complex and, consequently, require considerable investment and skills that only a few companies can afford.

接近七年前Matrox的Parhelia，XGI的Volari，和3DLabs的Realizm，都被扔进了历史的故纸堆。这当然有很好的理由，现代的GPU极度复杂，所以需要相当大的投资和技术，这只有少数的公司才能担负得起。翻译了一下，大体意思，不要挑刺。

The animal's way of "interpreting" a problem situation becomes more and more similar to that of humans as the experimental animal is phylogenetically closer to man.

动物「解决」困难情境时的方法，变得越来越与人类相似，正如被试验的动物有系统发生的接近人类。

Through the comparison of calculation results of two methods in the uniform and the non-uniform inflow, it is found that the results by two methods are very close. The calculation results by two methods are compared with open water test, and the agreement is well. The two methods can both perfectly simulate the hydrodynamics performance of podded propeller, and the method of induced potential needs less program work and can save a great deal of calculation time and memory space. It is a simpler and effective method to calculate hydrodynamics performance of podded propellers and other combined propulsions.

经过用两种方法对均匀来流和非均匀来流条件下水动力性能的计算比较，发现两种方法的计算结果很接近，并与模型试验结果吻合得很好，但用诱导速度势的方法编程工作量较诱导速度方法少，而且还可节省大量的计算时间和存储空间，是一种计算吊舱推进器和其他组合推进器水动力性能相对简单而且有效的方法。

E With the aid of a melting tank, Joncryl ADR-4368 becomes pumpable at temperatures about 120 - 140°C and very thin at temperatures approaching 200°C.

通过熔融槽，J4368在大约120 - 140°C时就可以用泵来抽送了，在接近200°C。时它会会变得非常稀。

When you share from your own experience ––– especially your failures –– you increase empathy, you're more approachable and you increase your relatability to others.

当你和别人分享到自己的那份经历时–––特别是自己失败经历的时候–––你的移情作用就会大大增加，你将会变得更容易接近，同时也增加了与别人的交流。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。