形态发生

The diagnosis of histiocytic/dendritic cell sarcomas is currently based on morphology and the presence of immunophenotypic features of H/DC differentiation.

现在对组织细胞/树突状细胞肉瘤的诊断，都是依据形态特征和H/DC分化特征的免疫表型。H/DC肉瘤是否发生了克隆性免疫球蛋白受体基因的重排，此问题争论了几十年。

Neurothekeoma and Plexiform Fibrohistiocytic Tumor: Mere Histologic Resemblance or Histogenetic Relationship?

神经鞘黏液瘤和丛状纤维组织细胞性肿瘤：两者仅是形态相似还是其组织发生有关联？

The colony morphology, growth rate and homothallic characters were all steadily inherited in both single-zoospore and single-oospore progenies,which indicated that the genetic factors of controlling the three characters were homozygous.

结果表明，菌落形态、生长速率和同宗配合性状在单孢后代可稳定遗传，控制上述性状的遗传因子是纯合的；大豆疫霉菌的游动孢子产生能力在单孢后代发生连续性变异，表明这种性状可能是数量遗传性状，也可能控制这种性状的基因为杂合基因或细胞质遗传因子。

OBJECTIVE: To observe dynamically the level of white blood cell and its morphological changes using automatic blood cell analyzer to evaluate its relationship with infection, immunosuppressive intoxation and acute rejection.

目的：应用全自动血细胞分析仪动态监测肾移植患者外周血白细胞数量和形态的变化，分析其与移植后机体感染、免疫抑制剂中毒及急件排斥反应发生的关系。

The results of the present research are as follows, The correlation between physico-chemical properties of organic compounds and their competitive power was studied, and it was indicated that organic compounds preferable to form H-bonding with organic matter of sorbents have stronger competitive power; Sorption behaviors of ionizable organic compounds in different species and their competitive power were examined, and the results showed that phenols and carbonxylic acids with benzyl circle have much stronger competitive power in molecular species than in ionized species, because negative charges of anionic forms can depressed their adsorption on the surface of the sediment; in contrast, organic bases such as aniline and p-chloroaniline show weaker competitive power in molecular species than in ionized species, and this is because both species of the organic bases could adsorb strongly onto the sediment; there is a correlation between competitive power of organic pollutants in multi-solute systems and their sorption isotherm nonlinearity in single-solute systems, and organic compounds whose sorption isotherms is linear in single-solute systems hardly have competitive power in multi-solute systems; Competitive sorption effects in more than two-solutes systems was studied, and it was exhibited that mixture of two cosolutes each of which could suppress sorption of nominal solute onto the sediment had synergistically competitive sorption effect on the nominal solute; A method about incorporating sorption/desorption of organic pollutants into river water quality model was developed, and discussion about degree of sorption/desorption effect on model prediction for different organic compounds was made, which will provide theoretical basis and practical processes for setting up more accurate water quality model.

论文主要取得了以下研究成果。(1)有机化合物的吸附竞争能力与其物化性质具有相关性，易与沉积物有机质形成氢键的化合物其竞争能力也比较强；(2)可离子化有机化合物的吸附竞争能力与其存在形态有关。酚类、含苯环的羧酸类化合物，其离子态的吸附竞争能力远小于分子态，其机理为有机酸阴离子所带的负电荷抑制了表面吸附能力，主要发生分配作用；而苯胺类化合物，其离子态和分子态都表现出显著的竞争能力，而且离子态的竞争能力略强于分子态，原因在于有机碱阳离子所带的正电荷促进了其表面吸附能力；有机化合物竞争能力的强弱与其单组分吸附等温线的非线性程度具有一定的相关性，吸附等温线近似为线性的化合物没有或只具有微弱的竞争能力；(3)对目标有机化合物的吸附具有竞争效应的有机化合物混合后，将对目标有机化合物的吸附产生协同竞争效应；(4)以京杭运河为例，率先提出了将有机污染物的吸附／脱附作用及水文水力参数耦合到水质模型中的方法，并讨论了吸附／脱附作用对不同有机污染物预测模型的影响，为建立更准确的水质模型及进行更客观的风险和生态评估提供了参考依据。

Result 1 Magnetic nanoparticles, magnetic nanoparticles modified with antisense oligodeoxynucleotide of human telomerase reverse transcriptase induced HL-60 tumor cells to apoptosis, we could see typical morphologic change of apoptosis cells: karyopyknosis, chromation"s condensing and aggregation in nuclear, forming crescent-shaped or annulus structures to lean on edge of cell nucleus"s membrane and posing apoptosis body by Atomic Force Microscope, Fluorescence microscope, transmission electron Microscope 2 There was a significant difference compared with control group(p.01), inhibition ratio had significant positive correlation with medication dosage and time ;during 0.8-8μM dosage amplitude, inhibition ratio accrescenced by dosages increasing. However, the inhibition ratio would decrease when dosage over 8-80μM.

结果 1 磁性纳米粒子、修饰有端粒酶反义寡核苷酸的磁性纳米粒子诱导HL-60细胞发生凋亡，原子力显微镜、光学显微镜、荧光显微镜和透射电镜下均观察到HL-60细胞呈现典型的凋亡细胞的形态变化：细胞核固缩，核内染色质浓缩、凝聚、形成新月形或环状结构紧靠在细胞核膜边缘，并形成凋亡小体。2 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子对HL-60肿瘤细胞的生长和增殖有明显的抑制作用，与对照组相比有显著性差异(p＜0.01)，在剂量为0.8-8μmol／L范围内，抑制率随剂量的增加而增加，当剂量超过8μmol／L时，抑制率反而下降；3 磁性纳米粒子、修饰有端粒酶反义寡聚脱氧核苷酸的磁性纳米粒子可增强p53基因的表达活性，引起DNA降解损伤，反向调节细胞周期活动，促使细胞从G0期进入G1期，抑制肿瘤细胞的生长。4 修饰有端粒酶反义寡聚脱氧核苷酸的量子点能通过内吞作用进入HL-60肿瘤细胞的细胞核，可以在细胞内进行定位和促进HL-60肿瘤细胞的凋亡。

Five new bacterial diseases of Ligularia fischeri, Vigna angularis , Brassica juncea var.japonica, Aconitum coreanum and Silybum marianum in Jilin province were firstly reported in the world; and their sympotoms of the diseases were described in detail. According to the configuration of the pathogens observed by electrical microscope, Gram staination, pathogenicity, cultural characters, physiological and biochemical characters, as well as G+C mol%, the pathogens were identified respectively .

首次报道了马蹄叶腐烂病、红小豆溃疡病、黄花乌头顶枯病、江户菜软腐病和水飞蓟软腐病在吉林省的发生，详细描述了该五种病害症状及危害情况；通过对分离的病原菌的电镜形态观察、革兰氏染色、致病性、培养性状、生理生化性状、G+C mol％等方面的测定，依据《Bergey's Manual of determinative Bacteriology》9th ed相关部分，初步确定了其病原菌的分类地位并对病原菌进行了室内药剂筛选。

Microscopically, retroperitoneal well differentiated liposarcomas appear identical to the well circumscribed atypical lipomatous tumors of neck, shoulder, upper back and other regions in extremities.

显微镜下，腹膜后分化良好型脂肪肉瘤在形态上与发生在颈、肩、上背和四肢其他部位的境界清楚的非典型脂肪瘤相似。

Dedifferentiated liposarcoma, occurring in up to 10% of well differentiated liposarcoma cases, has similar histologic features to that of undifferentiated high-grade pleomorphic sarcoma; the former develops in a background of atypical lipomatous tumors/well differentiated liposarcoma, whereas the latter shows no specific line of differentiation.

去分化脂肪肉瘤占高分化脂肪肉瘤比例达10%，其形态特征与未分化高级别多形性肉瘤有相似之处；前者发生在不典型脂肪肿瘤/高分化脂肪肉瘤的背景上，后者无特定分化方向。

The morphologic and immunohistochemical discrepancies between this intriguing melanotic tumor and other documented renal cell carcinomas bearing identical PSF-TFE3 gene fusion may suggest melanotic Xp11 translocation renal cancer is a distinct entity among the MiT/TFE family neoplasms.

与同样发生PSF-TFE3基因融合的其他已知肾细胞癌相较，此例的形态、免疫表型差异可以说明，黑色素性Xp11基因易位肾癌是MiT/TFE基因家族肿瘤中一个独特的实体。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。