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NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究,我们提出了初步的NodD操纵子激活模型:第一,四聚体是NodD蛋白的功能单位,它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子;第二,小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体,在我们的模型中,NodD四聚体缩小其V形主体的弯折角,进而缩短其DNA结合功能域的间距;第三,小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用,NodD的构象改变由蛋白质经其双铆钉位点传递给DNA;第四,只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物;第五,不排除NodD与RNA聚合酶可能有直接的相互接触位点,不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物,但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

Curved layouts of bonded and unbonded prestressed tendons can be considered in this model.

模型中可包含曲线布置形式的有、无粘结预应力束,模型中无粘结预应力束的计算不再需要迭代运算。

Skynet's most well-known products in its xenocidal goals are the various terminator models, such as the original "Terminator" character, portrayed by Arnold Schwarzenegger in 3 films. And now there are more toys on the rise from the newly vamped saga, starting with figures for the May 2009 coming Terminator: Salvation.

康纳带领人类反抗军与电脑系统天网作战之间的故事,在天网系统中最著名的机器人是各种终结者,比如原始的塞伯坦系统模型101终结者T-800,他由阿诺施瓦辛格在电影终结者三部曲中扮演,而且此系列模型的玩具以趋势化的形式增长,《终结者:救世主未来开启》将在2009年5月上映!

The high viscosity of polymer solution can improve the mobility ratio between oil phase and aqueous phase. Therefore, it can expand sweep efficiency of displacing fluid. In the model of multi-polymer commixing flooding mechanism, each polymer flows in the porous media on its own ability, and the enhanced oil recovery process is resulted from the total concentration of all the polymers.

在多种分子量聚合物溶液混合驱油机理数学模型中,每一种分子量聚合物在油藏中流动满足各自独立的物质传输规律,在驱油机理上表现为多种分子量聚合物溶液浓度之和的总浓度总体驱油过程,驱油机理数学模型中的参数表示为各种分子量聚合物相应参数浓度加权平均的形式。

After introducing the Boussinesq terms, which makes Boussinesq equation applied in the middle water depth and mild slope, and the wave energy loss term, the numerical modal of Boussinesq equation can accurately simulate irregular wave shoaling、refraction—diffraction and reflect in deep and shallower water.

在Boussinesq方程波浪数学模型的建立过程中,采用适用于中等水深(h/〓≤0.5)和缓变地形的Boussinesq项的修正形式,同时在基本方程中增加了波能损耗项,使该模型能够较精确地模拟波浪的浅水变形、折射、绕射、反射及其综合影响。

The dissertation systematically analyses RV-M1 robot which is used in this study, thoroughly dissects the hardware and software of RV-M1 robot's controller, upbuilds RV-M1 robot's model and coordinate system, develops the robot's forward kinematics formulation, solves the robot's kinematics negative problem, develops RV-M1 robot's dynamic formulation in Lagrange-Euler form, does linearization about robot's dynamics model, and gets this robot's sign solution In order to solve practical problem in the process of robot automatic polishing, this dissertation makes some beneficial researches and trials.

本文比较系统地分析了本论文研究中采用的RV—M1型机器人,较为详细地剖析了RV—M1型机器人系统的控制器硬件、软件,建立了RV—M1型机器人模型及其坐标系,推导出了该机器人的正向运动学方程,并对机器人的运动学逆问题进行了求解;推导了RV—M1型机器人的Lagrange—Euler形式的动力学方程,对机器人的动力学模型做了线性化,给出了该机器人的符号解。

Ccording to the characters of porous metals, a new effective bulk modulus formula with simpler expression was obtained by considering the heat exchange between the metallic skeleton and air in pore on the basis of phenomenological Biot-Allard model, therefore an extended sound absorption model was put forward.

bstract 根据金属骨架多孔材料的特点,在Biot-Allard刚性骨架多孔材料内流吸声模型的基础上,考虑金属的热导特性,推导出一种新的、形式较简单的有效体积模量表达式,从而得到了一种扩展的吸声模型。

Basing on the statistic datum existed of bridge deck pavements, analyze the main failure modes and its main causes to damage on different styles of bridge, at the same time, through the big calculation software ,establish the space models to simulate the course of mechanics of bridge deck pavements, analyze the main factors which affect the bridge deck pavement"s mechanics and the relations between them; according to the atmospheric circulation circumstances of bridge deck pavements, take the statistic datum of using life of prefabricated T-beam、box girders and casting girder in region of HUA-NAN as examples to returning analysis ,establishing the life prediction model of this style bridges; associating "the Method of Estimating to Life Cycle Costing,bring forward this method to take a evaluation of economy on bridge deck pavements, insure the life cycle costing reasonable; giving some tactics on the design of bridge deck pavements.

以既有桥梁的桥面铺装层使用现状统计资料为基础,分析了各种类型桥面铺装层的主要破坏形式及其主要损伤原因,同时利用结构分析软件,对桥面铺装层建立空间模型模拟其受力作用过程,分析影响桥面铺装层受力大小的主要因素以及各因素与铺装层受力大小之间的关系;按照桥面铺装层所处环境的不同,以华南地区预制T、箱梁和现浇梁的桥面铺装层正常使用寿命统计数据为例,通过回归分析建立该类型桥面铺装层的正常使用寿命预测模型;利用寿命周期费用评价方法,对特定铺装层的设计方案某一参数的变化所带来的经济效益进行评价;给出桥面铺装层设计构造建议。

The energy function is mainly made of intra-region similar properties based on proximity principle when contour curve is situated near the object edge.

该模型符合知觉特性,是几何活动轮廓模型的一般形式,且融合图像区域信息和边界信息。

It also derives calculation formulas of various dispersed coefficient to set up three-dimensional turbulence model of draft tube and confirm the solving method.

对流场控制方程及三维湍流模型进行了深入的分析与研究,导出了通用微分方程,用有限体积法推导了通用微分方程的离散形式,并导出了各种离散系数的计算公式,建立了尾水管的三维湍流模型,并确定了求解方法。

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For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降,而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新

Lao Qiu is the Chairman of China Qiuyang Translation Group and the head master of the Confucius School. He has committed himself to the research and promotion of the classics of China.

老秋先生为中国秋阳翻译集团的董事长和孔子商学院的院长,致力于国学的研究和推广。