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张力障碍

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Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率 1:1.83,40岁以上发病53例,受累部位依次为眼睑58例(89.2%)、口-下颌46例(70.8%)、颈部17例(26.2%);首发症状以眼部不适、眼睑痉挛最(42例,占64.6%),口-下颌肌张力障碍次之(17例,占26.2%);14例行头MRI检查者8例发现脑干或基底节区病灶;口服药物治疗37例,显效4例,有效16例,无效17例;15例行肉毒毒素局部注射者显效5例,有效9例,无效1例。

The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).in part of the patients, cranial mri examination could find focus in brainstem or basal ganglia. among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. while in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1:1.83,40岁以上发病53例,受累部位依次为眼睑58例(89.2%)、口-下颌46例(70.8%)、颈部17例(26.2%);首发症状以眼部不适、眼睑痉挛最多(42例,占64.6%),口-下颌肌张力障碍次之(17例,占26.2%);14例行头mri检查者8例发现脑干或基底节区病灶;口服药物治疗37例,显效4例,有效16例,无效17例;15例行肉毒毒素局部注射者显效5例,有效9例,无效1例。

Objective To observe the efficacy of deep brain stimulation in the treatment of one case of tardive dystonia.

目的观察脑深部电刺激治疗1例迟发性肌张力障碍的手术效果。

May cause extrapyramidal symptoms, such as: muscle tension, tremor, rigidity, salivation, bradykinesia, akathisia, acute dystonia.

可能引起锥体外系症状,如:肌紧张、震颤、僵直、流涎、运动迟缓、静坐不能、急性肌张力障碍

Methods A retrospective survey of 46 cases of dyskinetic cerebral palsy who were treated in Nanhai Affiliated Maternity and Children Hospital of Guangzhou TCM University from January 2005 to October 2009 was carried out.Based on the clinical characteristics,all the patients were divided into 3 types:dystonic type,choreaathetoid type and athetoidspastic type.

回顾性调查46例不随意运动型脑瘫患儿的临床特点,对张力障碍型、舞蹈徐动型、徐动痉挛型3种不同亚型患儿脑瘫粗大运动功能分级系统分级、粗大运动功能测试量表(GMFM88量表)评估结果进行分析。

Idiopathic torsion dystonia and Huntington's disease represent autosomal dominant inherited hyperkinetic disorders that vary considerably with regard to pathologic mechanisms and clinical penetrance.

特发性扭转张力障碍和 huntington ' s 病代表了常染色体显性遗传的运动机能亢进疾病,由于和临床外显率不同而有很大差别。

Other features that may occur include seizures, psychiatric problems, extrapyramidal signs such as dystonia, hypopigmentation, pancreatitis, malar flush, and livedo reticularis.

其它可能发生的症状包括癫痫、精神问题、如肌张力障碍等锥体束外症状、色素沉着不足、胰腺炎、颧颊潮红和网状青斑。

Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1:1.83,40岁以上发病53例,受累部位依次为眼睑58例(89.2%)、口-下颌46例(70.8%)、颈部17例(26.2%);首发症状以眼部不适、眼睑痉挛最多(42例,占64.6%),口-下颌肌张力障碍次之(17例,占26.2%);14例行头MRI检查者8例发现脑干或基底节区病灶;口服药物治疗37例,显效4例,有效16例,无效17例;15例行肉毒毒素局部注射者显效5例,有效9例,无效1例。

The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1:1.83,40岁以上发病53例,受累部位依次为眼睑58例(89.2%)、口-下颌46例(70.8%)、颈部17例(26.2%);首发症状以眼部不适、眼睑痉挛最多(42例,占64.6%),口-下颌肌张力障碍次之(17例,占26.2%);14例行头MRI检查者8例发现脑干或基底节区病灶;口服药物治疗37例,显效4例,有效16例,无效17例;15例行肉毒毒素局部注射者显效5例,有效9例,无效1例。

Meige syndrome are found more often in female seniors. Myodystonia is likely to involve eyelid, mandibula and neck. Cranial MRI is of diagnostic significance to some extent. Botulinum injection is more effective than oral drugs.

Meige综合征好发于中老年人,女性多见,肌张力障碍最常发生于眼睑,其次为口-下颌、颈部,头MRI有辅助诊断价值,肉毒毒素局部注射较单纯口服药物疗效好。

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