引起血管舒张的

The topical application of tanshinone IIA at one μg/ml and five μg/ml caused significant dose-related vasodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectively, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉，局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张，具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

The topical application of tanshinone IIA at one μg/ml and fie μg/ml caused significant dose-related asodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectiely, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉，局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张，具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

Background— It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation.

背景——过去已经提出，在缺氧条件下，亚硝酸盐会释放引起有效血管舒张的一氧化氮。

Results: The total saponins of Achyranthes Bidentata Blume not only had significantly inhibitive effects on NE-induced vasoconstriction, but also had direct relaxation effect on vascular smooth muscle.

结果：怀牛膝总皂苷不仅对NE引起的血管收缩有显著的抑制作用，而且还有直接舒张血管平滑肌的作用。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

The NO content and the NOS activity were down in the PIH pregnant women placenta.This showed that the ghrelin regulated the VEGF and influenced the the NO down.And the placenta angiospasm,blood pressure highten, and the PIH were caused also by this. The ghrelin,VEGF,Flt-1,NO and NOS were detected by the SP-immunochemistry, RQ-PCR,cell culture in vitro,ASODN and nitrate reductase in the normal pregnancy,PIH placenta and the cultured HUVEC antisense blocking ghrelin in vitro.

结果证实：PIH孕妇胎盘组织中Ghrelin，VEGF、Flt-1蛋白和mRNA水平下降与正常孕妇比较有显著性差异p＜0.05提示在PIH发病过程中Ghrelin可能对VEGF，Flt-1蛋白和mRNA的表达具有下调作用，进而影响胎盘血管网的形成和发育；NO含量与NOS活力水平在PIH孕妇胎盘组织中下降，提示Ghrelin可能通过下调VEGF的表达进一步影响血管舒张因子NO水平下降，进而引起胎盘血管痉挛，血压升高，最终导致PIH的发生。

Hypertension is one of the most important risk factors causing arthrosclerosis and vascular remodeling, hypertension and its etiology and pathology are closely related to ED.

高血压是引起动脉粥样硬化和血管重塑的重要危险因素之一，高血压与内皮舒张功能障碍之间存在密切关系。

The norepinephrine infused may increase the visceral-organs blood flow and has excellent effects to glomerular filtration rate and urine during the vasodilating status not like normal circulation.

在血管舒张状态，并不像正常循环情况，使用去甲肾上腺素可以提高内脏器官血流，并对肾小球滤过率和尿量具有良好效果，同时由于其使用可以避免过度扩容维持血压所引起的脏器功能恢复延迟。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果：①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用，且其张力变化在内皮完整与去内皮的血管环之间无显著性差异；②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加，其增加程度与内皮无关；③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义，且对去除内皮血管无显著影响；④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响；⑤无论是否去除内皮，SO_2衍生物均可引起cAMP／cGMP和6-Keto／TXB_2比值显著升高。

Abstract］ Objective To assess the endothelium-dependent relaxation in patients with essential hypertension or hypertension smokers by color Doppler flow imaging.Methods With intermittent ultrasound imaging and power Doppler imaging,we measured endothelium-dependent relaxing function in 72 subjects 24 of whom with essential hypertension,24 of whom with both hypertension and smokingand the others as normal control.We measured the diameter of the superficial femoral and brachial arteries at rest,during reactive hyperaemia,re-test and after sublingual glyceryl trinitrate for evaluating the endothelium-independent dilatation in subjects.The level of plasma NO,ET,PGI2,and TXB2 were determined.

摘要］ 目的探讨原发性高血压及高血压合并吸烟患者血管内皮依赖性舒张功能的改变方法采用彩色普勒高频超声的间歇成像和能量多普勒成像，对24例原发性高血压患者、24例高血压合并吸烟患者及24例正常血压无吸烟史者的血管内皮依赖性舒张功能，包括静息时血管内径、增加流量引起的血管舒张、硝酸甘油引起的血管舒张等，以及对血浆氧化氮、内皮素、血栓素B2（TXB2）和列腺环素（PGI2）等血管活性物质进行检测并比较分析。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。