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RESULTS: Both two recipes showed potent antifebril,anticonvulsive and sedative effects.

采用酵母引起的大鼠发热模型、伤寒副伤寒疫苗引起的兔发热模型、士的宁致小鼠惊厥及电惊厥模型等观察了2种配方的解热、抗惊厥和镇静作用。

OBJECTIVE: To study the effect of brain damage induced by repeated febrile convulsions during early life in rats.

目的:观察反复热性惊厥在幼年大鼠引起的脑损伤。

The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P<0.01) and prolonged latency period of shock (P<0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P<0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果:西替利嗪3×10-8~3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩,使组胺的量效曲线平行右移,pA2为9.34 ± s 0.61,西替利嗪0.1,0.2及0.4 mg.kg-1口服给药时,能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P<0.01),并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P<0.05),西替利嗪0.0625~0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高,使蓝染面积显著缩小(P<0.01),且存在明显的量效关系,3个剂量组的作用均优于氯苯那敏组。

Although the clinical experience and the results of animal experiments indicate that the adminis- tration of atracurium at recommended doese is unlikely to result in laudanosine concentrations capable of producing seizure activity, Hennis et al found that at a plasma concentration below that causing convulsions, laudanosine "awaken"dogs lightly anesthetized with halothane.

临床病人应用常用剂量阿屈宁后,血浆Laudanosine选低于使动物发生惊厥所需的浓度,数百万例应用阿屈宁的病人中也未见有因代谢生成之Laudanosine而发生惊厥体征或脑电征象者。可以认为,阿屈宁的临床应用是不会因Laudanosine的生成而引起惊厥的

39C ( 102f ). Illnesses that most commonly cause febrile convulsions include viral upper respiratory infections such as flu, ear infections, or roseola (a virus causing a temperature and rash).

疾病最常见的原因惊厥,包括病毒性上呼吸道感染,如感冒,耳朵感染,或roseola (一种病毒引起的温度及出疹的病征)。

IL-1βmRNA expression in the developmental brain in Wistar rat: IL-1β mRNA in hippocampus, cerebral cortex and subcortex was detected by postnatal day 1 and gradually increased with development, reached a peak at postnatal day 21, and then gradually decreased to lower level at adult; In P77PMC rat, IL-1β mRNA expression was similar to Wistar rat before postnatal day 14, then gradually increased and surpassed Wistar rat at postnatal day 28, reached a peak in adult.

原位杂交显示谷氨酸诱导Wistar大鼠惊厥和P77PMC大鼠听源性惊厥后脑内IL-1βmRNA表达情况。结果发现,两种不同惊厥模型大鼠惊厥后脑内IL-1βmRNA表达存在明显的差异。谷氨酸引起惊厥诱导脑内皮层、海马和丘脑IL-1βmRNA表达增高的程度远较P77PMC大鼠听源性惊厥为低,而且惊厥后IL-1βmRNA表达增加较慢,于4-8h达高峰,而听源性惊厥可于惊厥后2h迅速达高峰。但两种形式惊厥诱导脑内IL-1βmRNA表达最高的部位均是海马。

The pertussis vaccine may cause fever as high as 106 degrees, pain, swelling, diarrhea, projectile vomiting, excessive sleepiness, high-pitched screaming (not unlike the so-called cri encephalique, or encephalitic scream associated with central nervous system damage), inconsolable crying bouts, seizures, convulsions, collapse, shock, breathing problems, brain damage, and sudden infant death syndrome.

百日咳疫苗也许会引起高达106华氏度的高烧,疼痛,肿胀,腹泻,喷射式呕吐,整天昏昏欲睡,高声调的尖叫(和称为喊叫脑炎或者与中枢神经系统损伤的脑炎尖叫相象),难以自拔的不断叫喊,惊厥,抽搐,虚脱,休克,呼吸困难,脑部损伤以及婴儿卒死综合症。

These circumstances are believed to cause metabolic disturbances in neurons in the hippocampus, which may disappear and be subsequently replaced by gliosis.

MTS被认为与婴幼儿其的发热性惊厥和持续癫痫状态相关,这些事件被认为引起了海马区神经元代谢异常,这些神经元丢失并被神经胶质所取代。

Methods: nutmeg volatile oil gavage route of administration used to observe and calculate the value of LD50 in mice was observed in mice dose of pentobarbital sodium Excellency the hypnotic synergy strychnine convulsion convulsion caused by mice and the percentage of the incubation period, The incubation period the percentage of death and survival, as well as on coronary artery ligation in rats with acute myocardial infarction confrontation role.

肉豆蔻挥发油采用灌胃给药途径,观察并计算小鼠LD50值,观察对小鼠阁下剂量戊巴比妥钠的催眠协同作用,对士的宁引起小鼠惊厥的惊厥潜伏期及百分率、死亡潜伏期及存活百分率的影响,以及对冠脉结扎所致大鼠急性心肌梗死的对抗作用。

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Lao Qiu is the Chairman of China Qiuyang Translation Group and the head master of the Confucius School. He has committed himself to the research and promotion of the classics of China.

老秋先生为中国秋阳翻译集团的董事长和孔子商学院的院长,致力于国学的研究和推广。