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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Characteristics of different types of anomalous pressure were documented.

分析了引起地层压力异常的原因,阐述了不同因素引起的压力异常的特征,介绍了测井预测地层压力的等效深度及综合计算2种方法,给出了计算结果与测试结果的对比数据。

ObjectsTraditional Chinese Medicine is considered that gout belong to ""bizheng"" category, whichis related to diseases of ""gout"",""severe and migratory arthralgia"",""dermatophytosis"", andso on .

研究目的祖国医学认为,痛风性关节炎属于"痹症"范畴,相当于"痛风"、"白虎历节"、"脚气"等病,对其病因及发病机制的认识、看法颇多,但其确切的发病机理尚不十分清楚,目前认为是多种因素引起的尿酸钠微结晶在关节周围组织沉积引起的急性炎症反应。

Intraoperative acute encephalocele produce is caused by different factors.So it can be prevented and treated with corresponding measures to cut down the risk of acute brain encephalocele,and decrease the patients disability and mortality.

颅内肿瘤术中急性脑膨出由多种因素引起,针对病因采取积极适当的预防治疗措施,可以预防术中急性脑膨出的发生,减轻其发生后引起的脑组织损害,降低术后致残率和死亡率。

Crying at night caused a lot of factors, such as lack of vitamin B1, sleep disorders, etc.; ribs eversion may also Su-beam as a result of the chest caused by too tight.

引起夜间哭闹的因素也很多,例如维生素B1的缺乏,睡眠障碍等等;肋骨外翻,也可能由于胸部素束的太紧引起的。

There are many factor which influence on homogeneousness duringcooling.

冷却过程中的不均匀冷却引起应力和变形从而导致各点的收缩量不同,这是引起收缩的内在因素。

Background and Aims: The inner ear dieases caused by drug poison、 noise exposure、 senescence and viral infection can induce acoustic hair cell and neuron damaged,thereby cause inconvertible sensorineural hearing loss.

背景与目的药物中毒、强声暴露、老年化以及病毒感染等因素引起的内耳疾病均可使内耳毛细胞及神经元受损死亡,引起不可逆的感音神经性耳聋。

Caused by infection or capable of causing infection; viruses and other infective agents.

传染引起的或能引起传染的;病毒和其他传染因素。

Analyzed on the tunnels that used EPB method in different soils, the more logical three-dimensional finite element model is based, which can reality represented the soil transfiguration. 3 Due to the engineering example, a 3D FEM simulation model was founded. The model was used to study the rules of soil deformation and surface settlement during shield tunneling. 4 The characteristics of loess include the module, conglutination force and inner friction angle of the loess, affected the soil deformation. 5 The influence factors to the surface settlements such as the depth of soil, the outer diameter of the shield tunnel, the released stress at the cutting face, the fill ratio of the shield tail void, pouring-slurry press, thrusts and lengths of shield and digging steps were studied using the FEM method. References is brought forward in the loess areas of Xi'an was proposed.

通过对不同土质条件下盾构法进行地铁隧道施工的有限元分析,全面反映盾构推进对土体变形的影响情况; 3根据有关勘测资料,建立合理的盾构法施工三维非线性有限元模型,对盾构法施工引起的地层变位和地表位移情况进行计算,分析了盾构施工引起的地层变形规律和地面沉降规律; 4研究了黄土特性(地基模量、粘聚力和内摩擦角)对盾构法施工中土体变形的影响; 5利用三维有限元对盾构施工过程中影响地面沉降的因素(覆土厚度、隧道外径、开挖面压力变化量、注浆压力、盾尾空隙填充率、开挖步长、盾构机的长度和推进力等)进行研究,为今后西安地区地铁的建设提供参考。

It is important to differentiate immune thrombocytopenia from nonimmune thrombocytopenia because of the different clinical treatment, but untill now there is no satisfactory laboratory tests could be used.

非免疫性血小板减少性紫癜,是指由非免疫因素引起的血小板减少,如化疗后骨髓抑制、急性白血病、脾功能亢进以及恶性肿瘤骨髓转移等引起的血小板减少。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。