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It is reported that alkannin and shikonin isolated from the roots of Lithospermum erthyrorhizon or Alkanna tinctoria and their acylshikonin derivatives are potent selective inhibitors of DNA Topoisomerase Ⅰ.

文献报导紫草素和酰基紫草素等具有DNA拓扑异构酶Ⅰ的选择性抑制活性。本组曾合成得到少量环异紫草素(8),它对小鼠白血病P-388肿瘤细胞具有强烈的抑制作用。

It was noted that cell death from necrosis and autolysis would produce false-positive result because of non-specific DNA fragmentation.

提示类似泡状核细胞这类异染色质较少的细胞凋亡时可能都具有这种表现。

FUNGI Fungi are almost entirely multicellular, heterotrophic (deriving their energy from another organism, whether alive or dead), and usually having some cells with two nuclei multinucleate, as opposed to the more common one, or uninucleate per cell.

FUNGI Fungi是几乎完全地多细胞性,异养(获得他们的能量从另一个有机体,是否活或死)和通常有与二个中坚力量的有些细胞多核,与更加共同一个相对或者单核每个细胞。

MTT assay indicated that anti-proliferative activities in HeLa, SHIN3, HOAC-21 and HAC-2 cell lines were closely related to structure, 1,10-seco of eudesmane sesquiterpene lactone resulted in reduced anti-proliferative activity. The anti-tumor activity of isoalantolactone was probably achieved by inducing HeLa cell apoptosis.

提示A-环开环可能是导致桉叶烷型倍半萜内酯的体外抑制肿瘤细胞增殖作用消失或减弱的原因;异土木香内酯抑制肿瘤细胞增殖作用有可能是通过诱导肿瘤细胞凋亡机制而实现的。

The cytomorphological changes of K562 cells were observed in the electron microscope.Results RRTJ at the concentration of 1μL/mL expressed obviously inhibitory effect on the growth of K562 cells.The inhibitory effect at the concentration of 2μl/ml went up to its highest at 83.4%.RRTJ showed virulence to K562 cells.The karyon changed because of RRTJ attending.

结果 每mL培养液含1μL刺梨汁即对肿瘤细胞增殖有明显的抑制作用,每mL培养液含2μL刺梨汁抑制作用达到最大,为83.4%,再加大剂量抑制作用无明显升高,各种剂量的刺梨汁对细胞均无毒性,刺梨汁的加入使得细胞体积明显变小,细胞核形态发生改变,异染色质增多。

Drug intervention groups received either daily inhalation of budesonide, ipratropine or heparin respectively, starting on the 8th day or TGF-β1 monoclonal antibody(TB21)0.5 mg twice (6th and 19th day) via the tail veinous injection.

其它各药物干预组于制作模型第8 d起分别雾化吸入布地奈德(布地奈德组,12只)、溴化异丙托品(溴化异丙托品组,12只)和肝素(肝素组,6只)溶液。4周后检测小支气管平滑肌及胶原厚度,用免疫组化法及原位杂交法观察各生长因子在支气管肺内的表达,用放免法检测血清和BALF中细胞外基质成分Ⅲ型前胶原、层粘连蛋白及透明质酸。

Methods Using the long-distance RT-PCR and a mammalian expression system, the full length cDNA of the α1D was cloned from cochleae and then expressed in HEK293 cell line.

以耳蜗基底膜中组织总RNA为模板,利用长距离RT-PCR克隆耳蜗毛细胞表达的电压门控钙通道α1D剪切异构体,并利用异源表达系统在哺乳动物细胞系进行表达。

To explain relationship between the effect of CLD on senile Demention and neuron in hippocampal area. The change of natural aging mice's neuron in hippocampal area were studied by applying microscope and transilluminating electric microscope. Results: Comparing with the young control, the old control mice's hippocampus had less small pyramid cells, the nerve cells denaturalizing and their branches reducing in the microscope. Hippocampal nerve cells were degenemiceing, with nucleus membrance crinkling like wave shape were not clear, and chromatin condensing with high electron density, heterochromatin accruing, part cell organs inclosing nucleus, nucleus condensing in the EM.

为了阐明菖龙丹抗老年性痴呆作用与海马区神经元结构的关系,运用光镜和透射电镜观察了菖龙丹对自然衰老小鼠海马区形态的影响,结果显示老年对照组小鼠光镜下海马锥体细胞较青年对照组数量减少,细胞体积变小,神经元变性,分枝减少;电镜下海马神经细胞发生退化改变,核膜皱缩,呈波浪状,膜结构不清晰,核染色质浓缩,电子密度高,异染色质较多,部分胞浆细胞器向细胞核聚集,有的可见细胞核固缩。

In conclusion, species-specific responses of hepatocytes to cytokines and interactions with xenobiotic metabolites may limit the clinical effectieness of porcine hepatocytes in BAL.

结论,肝细胞之间对细胞因子的物种特异性反应及对异源性代谢产物的相互作用可能限制了猪肝细胞作为生物人工肝在临床的应用效果。版权声明:本译文文字内容归丁香园网站(http://www.dxy.cn)所有,未经网站书面许可,请勿转载或摘编。

The result of our study reveals that there are significant differences in expressions of ER-α and ER-β in stomal cells between eutopic and ectopic endometrium of endometriosis.

结果:子宫内膜异住症患者ER-α及ER-β在异位内膜间质细胞中的含量均低于在位内膜和子宫肌瘤患者在位内膜,但两组受体间均无明显差异。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

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