异细胞

Chromatin hetropycnote partly in spermatogonium, then become highly coacervate to form chromosome at the stage of spermatid and at last decondense at the stage of spermatozoon.

染色质在精原细胞中为部分异固缩，在精母细胞中高度凝聚为染色体，在精细胞及精子中为均匀非致密态。

The activated donor-type NK cells could prevent gVHD and produce significant GVT effects and also resulted in greater hematopoietic reconstitution if they were at the initial stage of allogeneic BMT in mice. Thereafter, the activated donor-type NK cells were detrimental and could exacerbate the subsequent GVHD, these results also demonstrated that GVT and GVHD could be dissociable phenomena.

①在小鼠异基因骨髓移植的初始阶段，输注供鼠的活化NK细胞能促进造血重建，预防GVHD并同时增强移植物抗肿瘤效应；输注骨髓细胞之后，输注供鼠的活化NK细胞则起到加重GVHD的不良作用；②GVT和GVHD是能够被分开的。

Pial basement membrane breaches and glia limitans disruptions are the underlying causes of cerebellar granule neuron ectopia in POMGnT1 knockout mice and that migration into the IGL is not required for their differentiation.

1。在POMGnT-1基因敲除小鼠中，导致小脑颗粒细胞异位的原因是软脑膜基底膜层和胶质细胞的界膜的破裂，而颗粒细胞迁移到IGL并非是分化所必需。

Classification examination was put into practice for only normal cells observed.For the dubious specimen,tuberculosis-Ab,acid-fast bacteria staining,flow cytometry,CD series,gene,DNA aneuploidy,ZPP and tumor markers etc were detected. Results Tuberculosis lymph gland inflammation coverd highest rate:546 cases (36%) in which tuberculosis node was 252 cases (46.2%),lymphonode period was 184 cases (33.7%),early tuberculosis lymphagland inflammation was 233 cases (44.7%).

利用改良一次性5～10ml注射器(22G、7号注射器，外径＜0.7mm)，针吸取材、涂片、行改良瑞-姬双染技术，低倍镜查找特殊异常细胞，油镜仔细观察细胞形态结构特征，对于未见异常细胞要进行分类检查，对疑难标本，同时做结核抗体、抗酸菌染色、流式细胞仪、CD系列、基因、DNA异倍体、锌原卟啉、肿瘤标志物等检测指标。

NF-κB is a kind of important nuclear factors which are relative to lots of cellular activities such as activation of immunocyte, development of T and B lymphocyte, stress reaction, cell apoptosis and so on. NF-κB exists in almost all types of cytoplasm in the unreactive form of heterodimer or homodimer.

核转录因子κB(nuclear transcription factorκB， NF-κB)是一类关键性的核转录因子，通常以同源或异源二聚体非活性形式存在于几乎所有类型细胞的胞质，其与免疫细胞的活化，T，B淋巴细胞的发育，应激性反应，细胞凋亡等多种细胞活动有关。

Thunberg Fritillary Bulb is one of the most popular Traditional Chinese herbs. Some trials in vivo and animals indicated that Peimine and Peiminine, extracted from Thunbery Fritillary Bulb, have the function of reversing MDR of two different kinds of mechanisms. They can improve the cytotoxic of ADR to cancer cells by 5～10 folds under concentration of 10% cancer cell growth inhibitory rate. Peimine and Peiminine not only feather typical character of modifier of MDR, but also differ from other moldifiers such as Calcium channel blocker, Cyclosporines in chemical structure, they belong to cevine groups alkaloid, a subgroup of C-Nor-D-homosteroid alkaloid.

浙贝母是临床常用中药，体外及动物试验证明，浙贝母中的有效活性成分贝母甲素和贝母乙素具有逆转肿瘤细胞MDR的作用，而且能逆转两种不同机制的多药耐药肿瘤细胞的耐药性，在无明显细胞毒剂量下，可使阿霉素对耐药肿瘤细胞的杀伤活性提高5-10倍，不但具备明确的多药耐药逆转剂的特征，而且在化学结构上属异甾类生物碱中的瑟文类生物碱，完全不同于钙离子拮抗剂、免疫抑制剂和其它现有的耐药逆转剂，具有作用靶点宽、化学结构独特的特点。

The heterogenic C57BL/6J splenocytes disappeared at 1 day after transfusion, but the syngeneic BALB/c splenocytes could survive for a long time in the peripheral blood of BALB/c mice. The fluorescence intensity was not decreased in two kinds of splenocytes. The results demonstrated that CFSE-labeling with difference concentration is reliable, stable and convenient for spleen lymphocytes tracing in vivo.

异基因的C57BL/6J脾细胞在输注1 d后就快速消失，而同基因BALB/c脾细胞能够在BALB/c小鼠外周血中长期存在，但是两种细胞荧光强度均未见降低，说明荧光染料CFSE差异浓度标记活细胞进行体内示踪是一种稳定的示踪方法。

The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells.

所述的异羟肟酸化合物还可以抑制组蛋白脱乙酰基酶并且适合于选择性地诱导终末分化，以及阻止赘生性细胞的细胞生长和/或细胞程序死亡，由此抑制这些细胞的增殖。

Bone marrow mesenchymal stem cells could differentiate into osteoblasts, adipocytes and neural like cells with osteoblast inductor (β-sodium glycerophosphate, dexamethasone, vitamin C), lipoblast inductor (dexamethasone, 3-isobutyl-1-methylxanthine, bovine insulin, indometacin) and serum-free medium inductor (dimethyl sulphoxide, butylated hydroxyanisole) respectively. Osteoblast marker (alkaline phosphatase, osteocalcin mRNA, calcium node), adipocyte marker (lipid droplet, PPAR γ-2mRNA) and neural cell-like marker (nissl body, neuron specific enolase, neurofilament protein) were respectively determined by the immunohistochemical method, polymerase chain reaction and immunocytochemical method.

分别采用成骨细胞诱导剂（β-甘油磷酸钠，地塞米松，维生素C）、成脂肪细胞诱导液（地塞米松，甲基异丁酸黄嘌呤，牛胰岛素，吲哚美辛）及二甲基亚砜和羟基丁酸苯甲醚无血清培养基诱导剂干预细胞向成骨、脂肪、神经细胞分化，经免疫组织化学染色、PCR、免疫细胞染色方法检测成骨标志物（碱性磷酸酶、骨钙素mRNA、钙结节）、脂肪标志物（脂滴、PPARγ-2mRNA）、以及类神经标志物（尼克氏体、神经烯醇化酶、神经丝蛋白）。

Then transplantation of the sciatic nerve from donor rats to the recipient rats in two groups were progressed.7 days after nerve transplantation,the contents of cd4 and cd8 in peripheral plasma of recipient rats were detected by flow cytometry.8 weeks after nerve transplantation,transplanted nerve were observed under light microscope.results:compared with nonirradiated group,the percentage of cd4 and the ratio of cd4 to cd8 in uvb irradiated group were significantly decreased（p＜0.05,p＜0.01）,cd8 percentage was significantly increased（p＜0.01）.conclusion:uvb-irradiated donor splenocytes were injected in the recipient rats through caudal veil,which could induce immunological tolerance to allogeneic transplantation.

未照射组注射未经紫外线照射的供体脾细胞，照射组注射经紫外线照射的脾细胞，7 d后移植供体神经。术后7 d行外周血t淋巴细胞亚群检查，术后8 w行移植神经组织学检查。结果：照射组cd4+百分率、cd4+/cd8+比值较非照射组明显降低（p.01，p.05），cd8+百分率较非照射组明显升高（p.01）。组织学检查显示，照射组的再生神经较非照射组多。结论：尾静脉内注射经紫外线照射的异基因脾细胞可诱导对异体神经移植的特异性免疫耐受。紫外线；脾细胞；免疫耐受；坐骨神经

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新