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异种移植

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Mice from MixTx group were transplanted with mouse islets and NICC admix grafts in the left kidney and NICC grafts in the right kidney. Only normoglycemic mice were undergoing the subsequent macrophage challenge.

1胰岛移植与巨噬细胞重建:STZ诱导的糖尿病NODSCID小鼠分别接受:Balb/c小鼠的胰岛移植,混合移植(左侧接受小鼠胰岛与NICC的混合移植物,右肾接受NICC异种重建后移植物)和NICC异种移植

In the allo- even xero-transplantation of these seed cells, graft rejection is an important problem.

在这些"种子细胞"的同种异体甚至异种移植过程中,人们不可避免地考虑到移植排斥问题。

Changdong" showed a noticeable enhancive effect when it was co-administrated with other anti-tumor agents or when it was co-applied with radiotherapy. The action mechanism study showed that an apparent cytotoxic effect of "Changdong" on ten tumor strains in vitro with a quantity-effect relationship was observed. Immunity experiment showed that "Changdong" could induce proliferation of spleen lymphocyte in mice bearing tumor and could improve NK cell" s activity, whereas has no impact on IL-2" s reproduction. It was also noticed that "Changdong" could induce human liver cancer QGY" s apoptosis in vitro, and it happened mainly on G0-G1 phase.

结果:"长动"对小鼠移植瘤模型和人体肿瘤裸鼠异种移植均有明显抑制作用,量效关系明显:"长动"与放疗和化疗分别联合应用有明显的增效作用:作用机制研究结果:细胞毒性试验研究表明"长动"在体外对10株肿瘤细胞有明显的细胞毒性作用,量效关系明显;免疫学试验表明"长动"可以诱导荷瘤小鼠的脾淋巴细胞增殖,增强NK细胞的活性,对IL-2的产生无明显影响;"长动"在体外可明显诱导人体肝癌QGY细胞凋亡,使细胞阻滞于G0-G1期。

The human preserved cartilage grafts with perichondrium were preferable to grafts without perichondrium.

培养的人的带膜软骨进行异种移植后,其移植排斥反应明显弱于不带膜软骨。

To observe analgesit effects of xenogeneic bovine chromaffin cells and protective effects of the alginate-polylysine-alginate microcapsule.

采用微囊化牛嗜铬细胞异种移植于大鼠和癌痛病人脊髓蛛网膜下方法,观察BCC镇痛作用和海藻酸钠-聚赖氨酸-海藻酸钠微囊对异种移植物的免疫保护作用。

Exogenic transplanted MSCs were not immune rejected,and did not initiate specific immune response during the second transplant.

MSCs异种移植未见明显的免疫排斥,不诱导机体产牛特异件免疫应答,多次移植可以改善功能恢复。

Objective: To optimize the culture system of hEGcs in vitro, select the hEGcs from subculture to transplant directly to the rat infarcted myocardium and observe the therapeutic mechanism of their heterotransplantation in the treatment for the rat myocardial infarction.

目的:优化人胚胎生殖细胞的体外培养体系,并将生长状态良好的传代的人EG细胞移植用于大鼠心肌梗死模型的治疗,探讨人胚胎生殖细胞进行异种移植对大鼠心肌梗死的治疗机制。

The major obstacle in xenograft is hyperacute rejection, which is caused by complements after they are activated by xenogeneic antigens combined with natural antibodies.

异种移植的主要障碍为异种抗原被人血清中天然存在的抗体结合、激活补体导致的超急排斥反应。

Although the deelopment of relatiely non-toxic immunosuppressie or tolerance-inducing regimens will be required to justify clinical trials using pig organs, recent adances in our understanding of the biology of xenograft rejection and zoonotic infections, and the generation of alpha1,3-galactosyltransferase-deficient pigs hae moed this approach closer to clinical application.

尽管用猪的器官去验证临床试验需要相对无毒的免疫抑制剂或致耐的方法,但随着近来我们对异种移植排斥生物学及动物传染病感染的深入理解,以及α1,3 半乳糖转移酶缺陷猪的产生,异种移植更接近临床应用。

The aim of the research is to discover novel genes that are associated with xenograft rejection. This will provide better methods to prevent and treat xenograft rejection.

本研究目的是寻找与异种移植排斥反应相关的候选基因,为异种移植排斥反应的预防和治疗提供新的实验依据。

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