异硫氰酸酯

According to the properties of substituted thiourea derivatives,4 symmetric and 12 unsymmetric thiourea compounds were synthesized by reaction of alkyl amine or substituted aniline with carbon bisulfide or some isothiocyanates .

针对不同活性的取代硫脲，采用脂肪胺或取代苯胺与二硫化碳或不同种类的异硫氰酸酯反应，合成了4种对称的和12种非对称的硫脲衍生物。

In order to find high active pesticide containing heterocycle, six novel terephthaloyl bisthioureas containing 1, 3, 4-thiodiazole were synthesized by the reaction of 2-amino-5-alkyl-1, 3, 4-thiodiazoles with terephthaloyl diisothiocyanate.

摘 要：为寻找高活性的含杂环农药，由中间体5-烷基-2-氨基-1， 3， 4-噻二唑与对苯二甲酰基二异硫氰酸酯反应，合成6种新的含1， 3， 4-噻二唑环的对苯二甲酰基双硫脲化合物Ⅲaf。

In order to find high active pesticide containing heterocycle, six novel terephthaloyl bisthioureas Ⅲ(subscript a-f containing 1,3,4-thiodiazole were synthesized by the reaction of 2-amino-5-alkyl-1,3,4-thiodiazoles with terephthaloyl diisothiocyanate.

为寻找高活性的含杂环农药，由中间体5-烷基－2-氨基－1，3，4-噻二唑与对苯二甲酰基二异硫氰酸酯反应，合成6种新的含1，3，4-噻二唑环的对苯二甲酰基双硫脲化合物Ⅲ。

Eight novel N,N′-naphthalene acyl substituted aromatic acylamino thiocarbamide s(Ⅱ1~Ⅱ8) were synthesized from aryl acylhydrazine and α-naphthalene acyl isothiocyanate, which was obtained by the reaction of potassium thiocyanate with α-naphthalene acyl chloride obtained from 2-naphthylacetic acid and thionyl chloride in anhydrous benzene.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯，与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯，再与芳基酰肼进行加成反应，合成8种新型N，N′-萘乙酰基取代芳乙酰胺基硫脲类化合物(Ⅱ1～Ⅱ8)。

A novel compound——N-naphthalene acylN′-substituted p-chlorobenzamido thiocarbamide was synthesized by reaction of p-chlorobenzamido hydrazine and α-naphthalene acyl mustard oil,which was obtained by potassium thiocyanate combined with α-naphthalene acyl chloride formed from α-naphthylacetic acid and SOCl2 in anhydrous benzene.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯，然后与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯，再与对氯苯甲酰肼进行加成反应，合成了新型化合物N-萘乙酰基-N′-对氯苯甲酰氨基硫脲，用薄层色谱法跟踪最后一步反应，确定了反应时间。

Naphthalene acetyl chloride was prepared firstly by the reaction between α-naphthylacetic acid and SOCl2 in anhydrous benzene,then reacted with potassium thiocyanate to obtain α-naphthalene acetyl isosulfocyanate,as taking an addition reaction with p-chloro benzoyl hydrazine the novel compound N-naphthalene acetyl-N'-p-chloro benzoylamino thiocarbamide was finally synthesized.

通过α-萘乙酸和SOC l2在无水苯中反应制得α-萘乙酰氯，然后与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯，再与对氯苯甲酰肼进行加成反应，生成新型化合物N-萘乙酰基-N'-对氯苯甲酰氨基硫脲。

Naphthalene acetyl chloride was prepared firstly by the reaction betweenα-naphthylacetic acid and SOCl2 in anhydrous benzene, then reacted with potassium thiocyanate to obtainα-naphthalene acetyl isosulfocyanate, as taking an addition reaction with p-chloro benzoyl hydrazine the novel compound N-naphthalene acetyl-N'-p-chloro benzoylamino thiocarbamide was finally synthesized.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯，然后与硫氰酸钾反应生成α-萘乙酸基异硫氰酸酯，再与对氯苯甲酰肼进行加成反应，生成新型化合物N-萘乙酰基－N'-对氯苯甲酰氨基硫脲。

Eight novel N,N′-naphthalene acyl substituted aromatic acylamino thiocarbamides(Ⅱ1~Ⅱ8) were synthesized from aryl acylhydrazine and α-naphthalene acyl isothiocyanate, which was obtained by the reaction of potassium thiocyanate with α-naphthalene acyl chloride obtained from 2-naphthylacetic acid and thionyl chloride in anhydrous benzene.

通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯，与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯，再与芳基酰肼进行加成反应，合成8种新型N，N′-萘乙酰基取代芳乙酰胺基硫脲类化合物(Ⅱ1～Ⅱ8)。

Part two: Using chloroformic ester reacted with potassuim thiocyanate to get thiocyanic esters. Then reacted with biological substituted pyrimidinamine to synthesize forty two thiourea compounds, thirty eight of them are new compounds. Their structures have been charactered by IR, 1H NMR and elemental analysis.

第二部分：先以氯甲酸酯和硫氰酸钾为原料合成异硫氰酸酯，再与有生物活性的取代氨基嘧啶反应，合成了一系列新的取代嘧啶基硫脲类化合物，合成的42个化合物中有38个为首次合成的新化合物，结构经元素分析、IR及~1H NMR得到确证。

Besides, benzyl isothiocyanate and phenethyl isothiocyanate increased caspase-3 activity. Therefore, benzyl isothiocyanate and phenethyl isothiocyanate induce apoptosis in human prostate cancer DU-145 cells.

由此可知，苯甲基异硫氰酸酯和苯乙基异硫氰酸酯会造成人类前列腺癌细胞株DU-145走向凋亡的命运，值得更进一步研究发展为抗癌药物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。