异构的

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aR10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C-,-O-C-,-NR8-C-,-O-C1-6alkanediyl-C-,-NR8-C1-6alkanediyl-C-,-S2-,-O-S2-,-NR8-S2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC, carboxyl, aminoC, mono- or di(C1-4alkyl)aminoC, C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; R5 and R6 are H or C1-6alkyl.

本发明涉及右式化合物其N-氧化物、盐、立体异构形式、外消旋混合物、前药、酯及代谢物，其中R 1 及R 8 各是氢、C 1-6 烷基、C 2-6 烯基、C 3-7 环烷基、芳基、Het 1 、Het 2 ；R 1 也可以是式(R 11a R 11b )NC(R 10A R 10b )CR 9 -之基；t是0、1或2；R 2 是氢或C 1-6 烷基；L是-C-、-O-C-、-NR 8 -C-、-O-C 1-6 烷二基-C-、-NR 8 -C 1-6 烷二基-C-、-S 2 -，-O-S 2 -、-NR 8 -S 2 -；R 3 是C 1-6 烷基、芳基、C 3-7 环烷基、C 3-7 环烷基C 1-4 烷基或芳基C 1-4 烷基；R 4 是氢、C 1-4 烷基OC、羧基、氨基C、一-或二(C 1-4 烷基)氨基C、C 3-7 环烷基、C 2-6 烯基、C 2-6 炔基或任选被取代的C 1-6 烷基；R 5 及R 6 是氢或C 1-6 烷基。

The enthalpic term is dominant in the determination of tautomeric equilibria.

溶剂化自由能与异构体的气相偶极矩存在相关性。

Both 2-hydroxyethyl and oxametallacycle species tautomerize to acetaldehyde, around 210 K and above 250 K, respectively. Some of that acetaldehyde desorbs while the rest decomposes to hydrogen and carbon monoxide.

羟乙基和氧金属环都会发生异构，分别在210 K和250 K生成乙醛，这些乙醛一部分从表面脱出，其余的部分发生分解反应产生氢气、水和一氧化碳。

Structural analysis reveals that the assemblies of these complexes are mainly directed by counter anions, followed with the change of anions from simple inorganic species (SCN~-/dca/Cl~-) to organic ones (ip/nip/tp/chdc), diversiform structures are formed varying from mononuclear, tetranuclear molecules to infinite 1-D and 2-D frameworks.

第三章利用4-bpt的同分异构体4-氨基-3，5-双(2-吡啶基)-1，2，4-三唑(2-bpt)作为螯合试剂，与多种无机/有机阴离子以及金属Cd~盐反应，得到了一系列Cd~配位化合物(7-15)。

Density functional method was applied to the study of the isomers of the primary explosive of tetrazene.

采用密度泛函理论对四氮烯起爆药的异构体进行研究。

The geometrical structures of the three isomers of tetrazene molecule which had been proposed formerly were fully optimized at the B3LYP/6-311 +G(superscript **) level of theory.

在B3LYP/6-311+G水平下对四氮烯三种异构体分子的几何结构进行全优化计算。

objective: to investigate the relationship between topoⅱαand mgmt and its clinical significance in human breast cancer.

目的：探讨乳腺癌中拓朴异构酶ⅱα和dna修复酶表达的相关性及临床意义。

Objective: To investigate the expression and their correlation of P-gp,GST-π,TopoⅡ and p53 in breast carcinoma.

目的：探讨乳腺癌中P-糖蛋白，谷胱甘肽-S-转移酶，拓扑异构酶和P53的表达及相关性。

He expression of TOPOⅡ may be of significant clinical value in the chemotherapy design.

OPOⅡ在高中分化食管鳞状细胞癌的表达低分化者，提示食管癌高分化者对拓扑异构酶抑制剂化疗药敏感、预后好。

The reaction of isomerized butadieneiron complex (I; R = Ph, p-tolyl) with triphenylphosphine and tri-Ph phosphite gave products II (same R; R1 = Ph, OPh), at -60 to -30? When I was reacted with triphenylphosphine in hexane at 60 to 70?

丁二烯二羰基铁配合物的异构化产物，C4H62FeC(OC2H5)Ar(1，Ar=苯基， 2， Ar=对甲苯基)，在己烷溶液中于-60到-40℃与三苯膦或亚磷酸三苯酯反应生产产物3-6。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。