异常的

Those patients who dropped out did so mostly in relation to job and family commitments, and did not differ significantly from the rest of the group, either in relation to baseline demographics, clinical parameters, or the prealence of MRI structural abnormalities (they had a nonsignificant tendency to be younger and hae fewer MRI abnormalities).

那些脱落的病例主要是因为工作或家庭事务的原因，且剩下的组间没有显著的差异，无论是关于原始的一般资料，临床参数，还是MRI结构异常的发生率（他们有一种不太显著的倾向，越年轻的患者MRI异常越少。

While we were trying to understand the origin of subcontinental mantle anisotropy by SKS splitting measurements in Qinghai-Xizang plateau, we were perplexed for answers to the following questions:(1) why the inefficient Sn propagation region correlates with the large delay time (1.91-2.40s) of SKS splitting,(2) why very strong δt variations occur at the edges of this region, and (3) what results in the abnormal delay time.

当人们试图解释青藏高原异常的剪切波分裂成因时，以下的问题让人们感到困惑：为什么异常大的SKS分裂延时(1.91-2.4s)出现在青藏高原北部Sn波缺失区；(2)为什么分裂延时突变（1.47s和1.09s）出现在Sn波缺失区的边缘；(3)为什么快波极化方向与地表大规模的构造走向之间存在约20°-30°的偏差。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

Moutains of evidences from laboratary and clinical data show that gene abnormality is the major etiological factor of over 40% patients affected with epilepsy.There were also 6 epilepsy genes been cloned successfully, and mutations of over 1000 genes maybe related to epilepsy. These abnormal genes influence many aspects from molecular level to the neuronal plasticity, such as the development of brain,neuronic degeneration, remodeling of neural circuits, energy metabolism, ion channel and so on.These factors would at last affect the formation of epilepsy focus, propagations of epileptic potentials, vulnerability of epilepsy cells.

大量的实验和临床资料提示基因异常是40%以上癫痫患者的病因，有6种常见全身癫痫的基因已被成功克隆，1000种以上的基因突变可能与癫痫的发作有关，这些表达异常的基因分布在脑发育、神经元变性及神经环路重组、能量代谢、离子通道等多个环节，从分子、细胞、神经元可塑性等多个方面影响着癫痫灶的形成、痫性放电的扩布及癫痫细胞的损伤，构成了癫痫的基因机制。

It has been well documented that the fibular collateral ligament is the primary varus stabilizer of the knee.8,10 Consequently, isolated FCL injuries can elicit abnormal varus knee instability that can lead to functional limitations, a varus thrust gait pattern, and the potential development of medial meniscal tears or medial compartment arthritis over time due to the increased compressive forces at the medial tibiofemoral compartment.16,23,30 In addition, it has been demonstrated that varus instability, primarily due to a deficient FCL from an untreated posterolateral knee injury, causes a significant increase in force on both anterior cruciate and posterior cruciate ligament reconstruction grafts.11,21,22 Therefore, a reconstruction technique to address nonrepairable acute or chronic isolated FCL tears is important to address these pathologic abnormalities.

已经证实腓侧副韧带是防止膝关节内翻的主要稳定结构[8，10]。因此，FCL离断伤可以引起异常的膝关节内翻不稳定，从而导致功能受限、膝内摆步态和潜在发展为内侧半月板撕裂或由于在增加胫股关节间隙的压力会随时间推移发生内侧间室关节炎[16， 23， 30]。此外，已经证实了主要由膝关节后外侧损伤后未经治疗导致FCL功能缺陷引起的膝内翻不稳可以引起前交叉韧带和后交叉韧带重建移植物受力明显[11，21，22]。因此，认为不可修复的急性或慢性FCL离断撕裂伤的重建技术对这些病理异常非常重要。

Researching the occurrence characters of ore deposits, we found that the overlapping places or near districts of metallogenic factors, such as linear structures, ductile shear zones, circular structures, intrusting bodies, and alteration abnormal features are favorable for ore deposition

从区内已知的Au、Cu、Mo等矿床、矿点、矿化点及一些Au、Cu、Mo等多金属元素化探异常的产出特点看，本区的线性构造、韧性剪切带构造、环形构造、岩浆岩侵入体及蚀变异常等尽可能多的有利成矿信息的复合部位及附近，为成矿的有利环境或地段。

With the methods of Reverse transcription-PCR and cDNA sequencing, the expression of FHIT gene was detected in radiation carcinogenesis. The results show that: 1, The FHIT gene's sequence in normal BALB/c mice compare with the sequence of mice in Ge neBank which absents exon 3, but the function of FHIT protien doesn't alter.

结果发现：1、正常BALB／c 小鼠的FHIT基因序列同GeneBank中小鼠的FHIT基因序列比较缺少了外显子 3，但其表达的蛋白功能并未发生改变；2、FHIT基因在辐射损伤与辐射致癌的早期过程中，对照组血液、胸腺及骨髓均未出现异常的FHIT转录本的表达，不同剂量照射组中血液、胸腺及骨髓均有部分样品出现分子量较小的异常FHIT 转录本的表达。

The author has made a detailed analysis of the satellite gravity data over Wenchuan, Motuo, Zhongba, Jiashi and Taiwan Areas in China, where earthquakes more than magnitude of 6 took place in recent several decades. It is surprising that the gravity field patterns over these areas are extremely similar, which is characterized by the following features:(1)Paired positive and negative anomaly.(2)Epicenters usually were located between the pairs where the gradient of gravity field was the steepest.(3)The value of positive peak increased and its width decreased at higher order field.(4)The distance between positive and negative peaks varies in different tectonic background.(5)Different styles of crustmantle material diapirism in different stress fields. Geologically, rheological diapirism of high density crustmantle material could be a reasonable explanation to this unique pattern.

笔者详细分析了中国汶川、墨脱、仲巴、伽师和台湾等地的卫星重力资料(这些地区在近几十年来均发生过6级以上的大地震)，惊奇地发现，在这些地区，卫星重力场的样式具有极大的相似性，它们表现在：(1)卫星重力场的正负异常值成对出现；(2)震中通常位于重力场峰值间的陡梯度带；(3)由低阶到高阶的重力场正异常的峰值增大而宽度变窄；(4)正、负峰值间的距离随所处的大地构造背景而变；(5)不同应力场壳幔物质底辟的样式不同，从地质上看，高密度壳幔物质的流变底辟作用，可以合理地解释这种独特的样式变化。

The therapy of protection of liver function is very necessary: diammonium glycyrrhizinate can recover the non-specific damage of liver cells, Fufangdanshen can improve the microcirculation of liver, and tiopronin and reduced glutathione has the unique function to recover liver damage caused by fat invasion. Of 168 cases, 60 cases (35.7%) show exacerbation of liver function after using fat-reducing drugs for 1-2 weeks. Of 41 cases (male 36 and female 5) with the complication DM2, 58.5%(24/41) of cases also show exacerbation of liver function after using sugar-reducing drugs.

保肝治疗非常必要，甘草酸二铵有修复非特异性的肝细胞损伤的作用，复方丹参可以改善肝脏微循环；硫普罗宁或还原性谷胱甘肽，对于脂肪肝之由于脂肪浸润引起的肝细胞损伤的修复有独到的作用。168例中有60例（35.7%）因用降脂药物1～2周出现肝功能异常的加重；合并2型糖尿病的41例（男36例，女5例）患者中有58.5%(24/41)的人用降糖药物后也出现肝功能异常的加重。

P wave velocity structure in the crust of the Yellow Sea region was inverted by using P wave arrival data from the earthquakes recorded by Chinese, Korea and ISC stations. Taken together with gravity anomaly and fault system, Pn velocity and anisotropy, we analyzed the relation of various geophysical anomalies and the tectonic difference in the western and eastern Yellow Sea. This work provided further information for locating the eastern Yellow Sea fault zone and the collision boundary between the Sino-Korea and Yangtze blocks.

利用中国、韩国和ISC台站的地震走时数据反演了黄海地区的地壳P波速度结构，对比重力异常和断裂体系、Pn波速度及其各向异性，分析了不同地球物理异常的相互关系以及黄海东部和西部的结构差异，为厘定黄海东部断裂暨中朝—扬子块体的拼合边界提供了新的信息。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。