异常生长的

The results were analyzed with the statistical software package spss10.0.results ①between two groups,there was no significant difference about the affection of age,sex and the destribution and location of aneurism on prognosis outcome(p＜0.05).however,the grading of hunt hess and fisher in group a(gos＞3) showed significantly lower than in group b(gos≤3),（p＜0.001）;② there was no significant difference in the frequency of heart rate, st elevation, st depression,t wave inversion,u wave inversion and ventricular arrhythmia(p＞0.05).the frequency of abnormal q wave, supraventricular arrhythmia and the ecg scores in group a showed significantly lower than in group b （p＜0.05,p＜0.001）;③the ecg scores was the most powerful multivariate risk stratified(ecg ≥5 vs ecg＜5; p=0.002,or=0.010,95%ci 0.001~0.173).conclusion the ecg score, a new and simple method of semi quantification, was a powerful risk predictor for patients with sah.

应用spss10.0 统计包分析结果。结果①在年龄、性别、动脉瘤生长部位影响动脉瘤性sah预后方面，两组病例无明显差异（p＞0.05）。而按sah后hunt hess分级和fisher分级，gos＞3病例的分级要明显低于gos≤3的病例的分级（p＜0.01）；②两组在心率、st段抬高、st段压低、t波倒置、u波倒置、室性心律失常出现的频率无明显差异（p＞0.05）；在异常q波和室上性心律失常出现频率及心电图评分方面，gos＞3的组别明显低于对照组（p＜0.05，p＜0.001）；③心电图评分是sah患者预后最显著影响的变量（p=0.002，or=0.010，95%的可信区间0.001~0.173）。结论心电图评分作为一种新型、简便的半定量方法，能有效的预测蛛网膜下腔出血病人的预后。关键词：心电图；预后；评分；蛛网膜下腔出血

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors.

最终在兴奋性毒性（过度刺激神经元上的递质受体）、钙紊乱、炎症、能量和生长因子缺乏作用下，敏感的神经元发生萎缩、死亡。apoE4与Aβ和tau的异常聚集有关，还可能损伤线粒体和其他细胞骨架。Aβ、tau、apoE和synuclein与其他分子相互作用，影响多种神经活动和存活的信号转导途径。

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

Diabetic retinopathy is one of the most serious microvessel complications of diabetes,it is a main cosmopolitan blindness disease. In recent years, with the molecular biology development, the recognition of the mechanism of DR is more profound and consummate. Most researchers consider that hyperglycaemia, polyalcohol inositol metabolism abnormality, changes of hemorrheology, oxidative stress, inflammation/immune system activation, cytokines/growth factors expression or activity change and so on result in DRs onest and development.

糖尿病性视网膜病变(diabetic retinopathy， DR)是糖尿病最严重的微血管并发症之一，也是一种世界性的主要致盲眼病，近年来随着分子生物学方面的研究进展，对DR发病机制的认识进一步深入和完善，认为高血糖、多元醇肌醇代谢异常、血液流变学改变、氧化应激、炎症/免疫系统活化、细胞因子/生长因子表达或活性改变等导致DR的发生发展。

On the termination date, the cultured explants were all examined by Western blot, HE and transmission electron microscope. Our results showed that after 12-days in culture, the cultivation treated with AS-ODN reduced the synthesis of AMBN and had a deformed dental cusp with thinner enamel matrix. Ultrastructure analyses showed that there was hardly any cisternae of the rough endoplasmic reticulum in the ameloblasts at the tip of the cusp of AS-ODN treatedexplants. However, on average the enamel matrix was thinner compared with that in the control group. Furthermore, the collagen fibers in extracellular matrix were found disorganized. These findings seemed to provide a direct experimental evidence that tended to indicate that the arrested AMBN translation in cultured tooth germs might result in the delay of the tooth development.

经用Western蛋白印迹检测表明，所设计的反义核酸对AMBN InRNA具有良好的封闭效果并成功阻断了牙胚对AMBN的表达；在缺乏AMBN情况下，与对照组相比，实验组牙胚在体外可以继续生长发育至钟状晚期，出现成釉细胞和成牙本质细胞的分化，成釉细胞可以分化成为分泌期型成釉细胞，胞浆中缺少合成蛋白质所必需的粗面内质网和高尔基氏体，缺乏溶酶体，表明对蛋白合成和脚的能力降低；实验组牙胚有牙尖形成和基质分泌，但牙尖形态异常，基质形成减少，牙尖周围基质最厚处为O.6卜m，明显薄于对照组的5.spin，基质中胶原纤维粗细不等，排列稀疏， 3 第四军医大学硕士学位论文未见钙化现象，充分证明了AMBN在牙胚发育中参与釉质基质形成和矿化过程，影响胶原纤维和牙本质基质的合成，促进成釉细胞对蛋白质的合成和釉质基质蛋白降解。

Oxygen is not only a life-sustaining element to the existence of organism but also a key regulatory factor in cells physiological function.

氧气是机体生命活动所必需的重要元素，氧的供应不足会导致细胞的生长、分化和凋亡发生不同程度的异常改变。

Female Tigons and Female Ligers both possess a tiger X chromosme and a lion X chromosome, yet only the female Ligers will grow large, this means something must happen to either alter the genes or that the cause of the growth dysplasia lies at least partially outside of the genes.

雌虎狮兽和雌狮虎兽都有一个老虎的X染色体和一个狮子的X染色体，但是只有雌狮虎兽会长成庞然大物，这说明一定有什么事情发生了，改变了每一方的基因，或者狮虎兽的生长异常有基因之外的某些原因。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。