异基因

Objective: To study the relationship between donor blood derived allogeneic chimerism and levels of tolerance induced in the host mice, parabiosis between adult mice with H-2 complete difference was established.

摘 要：目的：探讨供体源的异基因血细胞嵌合体与受体耐受状态的关系，在不同品系的成年小鼠之间成功地建立了联体模型。

Department of Immunology, Beijing Medical University,Beijing 100083）Abstract:Objective: To study the relationship between donor blood derived allogeneic chimerism and levels of tolerance induced in the host mice, parabiosis between adult mice with H-2 complete difference was established.

摘 要：目的：探讨供体源的异基因血细胞孩子嵌合体与受体耐受状态的关系，在不同品系的成年小鼠之间成功地建立了联体模型。

Department of Urology, the First Affiliated Hospital of Liaoning Medical University, Jinzhou121001 ChinaAbstract: Objective To establish rat models for studying recipient kidney function of renal allograft tolerance induced by parabiosis combined with cyclophosphamide on rats.

目的 建立异基因大鼠联体共生的动物模型，探讨诱导免疫耐受对其肾功能的影响。

Objective To explore the status of immune reconstitution in leukemia patients with cGVHD after allogeneic hematopoietic stem cell transplantation.

目的 研究异基因造血干细胞移植后合并慢性移植物抗宿主病时的T细胞免疫状态。

The results showed that 11 patients (7 patients after auto-PBSCT, 4 patients after allo-PBSCT) all achieved hematopoietic reconstitution and complete remission.

结果表明：HSCT后11例患者(其中自体移植7例，异基因移植4例)造血顺利恢复，均能达到完全缓解。

Objective To investigate the value of sequential and quantitative analysis of donor chimerism to predict the outcome of allogeneic hematopoietic stem cell transplantation, to determine the optimal time point of adoptive immunotherapy and to estimate the efficacy of adoptive immunotherapy.

目的探究供体细胞嵌合率的动态定量检测在预测异基因造血干细胞移植后的转归，确定过继免疫治疗时机和评价AIT疗效中的作用。

Objective To investigate the effect of allogene hepatic nonparenchymal cell on the survival of grafted skin in mice and its underlying mechanism.

目的探讨输注同种异基因肝脏非实质细胞对小鼠移植皮片存活的影响及其机制。

Methods: the first experiment Immunetolerance in mice sciatic nerve allograft by intrathymic injection of allogene: 48 mice were divided into 4 groups randomly: Group A,Group B, Group C and Group D(nerve allograft under immunosurppressant).

研究技术路线：第一部分：小鼠胸腺内注射异基因抗原在同种异体坐骨神经移植免疫耐受中的作用 1、动物分组：48只Balb／c小鼠随机分为4组，A组；B组；C组；D组(异体神经移植加用免疫抑制剂组)。

There is no mature scheme on haploidentical non-T-depleted transplantation in China. Prognosis of chemotherapy is poor for refractory and high-risk leukemia. Allogene hematopoietic stem cell transplantation should be applied without delay. If we can go beyond the histocompatibility leukocyte antigen boundary, HLA-haploidentical family members would became the resource of allo-HSCT donors.

目前，国内外尚无单倍型相合未去T细胞移植成熟的方案，对于难治和高危白血病患者，化疗预后是很差的，应不失时机进行异基因造血干细胞移植，如果能够跨越人类主要组织相容性抗原的限制，用人类主要组织相容性抗原半相合的亲属作为造血干细胞移植的供体，就可以彻底解决干细胞来源问题。

Microsatellite Allogene Haematopoietic stem cell Engraft evidence

微卫星；异基因；造血干细胞移植；植活证据

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失