异基因

RT-PCR detection of SYT-SSX mRNA can be used in formalin-fixed, paraffin-embedded tissues as a sensitive and specific technique in the diagnosis and differential diagnosis of synovial sarcoma. 2. The SYT-SSX fusion type is related to histological type and cell proliferative activity of synovial sarcoma. 3. Some characteristic sequence motifs flank genomic breakpoints of chromosomal translocation of synovial sarcoma, including Alu sequences, Translin recognition sequences, topoisomerase Ⅱ recognition sites and palindromic sequences, which may be associated with chromosomal translocation of synovial sarcoma.

1、RT-PCR技术检测SYT-SSX mRNA表达可用于福尔马林固定、石蜡包埋组织，敏感性和特异性高，可用于滑膜肉瘤诊断和鉴别诊断。2、SYT-SSX融合基因类型与滑膜肉瘤组织学分型及细胞增殖活性相关。3、滑膜肉瘤染色体易位断裂点旁存在一些特征性序列，包括Alu序列、易位素识别序列、拓扑异构酶Ⅱ识别位点、回文序列等，可能与其染色体易位发生机制有关。

There are four kind of isoforms of endothelin in human and other mammals named ET-1, ET-2, ET-3 and ET-β, which are slightly different in construction and pharmacological effect. In human beings, ET-1 is the dominative subtypes. ET-1 remains in blood at a low level about 5ng per liter on physical state. It is synthesized, stored, released and metabolized locally. The half-life of ET-1 is about 1 hour. ET-1 is the most potent vasoconstrictive factor till now, and it is more functional in vein than in artery. In vascular bed, there are two kind of ET receptors. Type A mainly located in smooth muscle cells, whereas type B in endothelial cells. The latter can stimulate intimal hyperplasia via a parasecretion way and activate some oncogenes such as c-fos and c-myc and then enhance their expression. These alterations result in constriction of blood vessels, thus the SMC steps into proliferate state from silent state.

人及哺乳动物体内有四种结构及药理学性质略有差异的异物体，分别为ET-1、ET-2、ET-3、ET-β，而在人主要是ET-1，在生理条件下，ET-1在血浆中含量较低，约为5ng〓，故ET-1不是一个循环激素，而是局部合成释放，局部起作用的活性物质，半衰期约1小时，ET-1是目前已知的最强的血管收缩剂，对静脉的作用比动脉强，在血管床，ET受体有A、B两型，A型主要分布在平滑肌细胞，B型主要分布在内皮细胞，它可以通过旁分泌途径刺激内膜增生，具有有丝分裂原效应，可以激活某些癌基因如C-fos、C-myc使其表达增强引起血管收缩，使静止期SMC进入增殖期，还可以通过信号传导途径，与bFGF、GTF-β、PDGF等生长因子协同作用，起共有丝分裂原作用。

This indicated that pgi gene is involved in gluconueogenesis. The virulence of pgimutant was tested on Chinses radish Raphanus sativus L. var. radical us Pers.

碳源利用检测结果表明，pgi突变体对多种碳源，例如柠檬酸、琥珀酸、延胡索酸乙酸、乳糖等的利用能力很差，这说明该基因在糖异生途径中起重要作用。

Sequence analysis revealed the presence of a 735 bp open reading frame encoding 244 amino acids protein, which shares 32.9 %~49.2% amino acids sequence similarity to PRAI proteins from other species of Saccharomycetales.

序列分析显示，该基因编码区全长735 bp，编码的磷酸核糖氨基苯甲酸同分异构酶氨基酸序列与其他酵母来源的PRAI蛋白同源性在32.9%~49.2%之间。

Objective To explore the differential expression of homeobox genes in the normal , wounded human fetal and adult skins and its significance in fetal scarless healing.

目的探讨人胎儿及成人皮肤创面愈合过程中同源异形框基因的差异表达。

Results For TCF-4 gene, multiple isoforms are generated by way of alternative splicing, which encode different proteins.

结果 对于TCF-4基因，不同的剪接形式产生不同的异构体，编码不同的蛋白质。

ITS2(Intemal Transcribed Spacer 2) region in ribosome DNA has a character of conservative that makes a low aberrance ratio, on the other side, ITS-2 region evolves itself. According to the characters, ITS-2 region sequencing is an effective parameter in taxology and pests-control..

核糖体基因的第二内转录间隔区有较高的保守特性，同时进化速度又较快，因此序列进行测序得出的种内差异，是系统发育学的有力参数，也有助于异色瓢虫分类学和农林虫害的防治。

Phosphorylated Stat5a and Stat5b form homo-or heterodimers and translocate to the nucleus where they activate genetic programs of cell proliferation and differentiation.

磷酸化的Stat5a和5b可形成同源和异源二聚体并进入细胞核激活下游基因引起细胞的增生和分化。

Isorhmnetin ; Uterocervical cancer ; Oncogene ; Apoptosis

异鼠李素；宫颈癌；凋亡；癌基因

Maize inbreds are xenial. For the hybridization along with continuous gene exchange among different plants creating a new hereditary variation pool and thereafter on the effect of natural selection and artificial selection, it creates a new germ plasm which is different from the original germ plasm at quite a large extent.

玉米是异花授粉的，在不同植株之间，由于杂交以及相伴随的连续的基因互换会创造出新的遗传变异库，其后在自然选择和人工选择的作用下，产生在相当程度上不同于原始亲本种质的新种质。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失