异吡唑

The invention relates to the synthesis of N-aryl group-3-(4-Beta-D-pyran allose glycoside phenyl)-5-formyl isoxazole-4-formamide and discloses a helicid derivative which can improve the functions of a central nervous system and the preparation method thereof; wherein, the compound has good sedative, hypnotic and anti-convulsant effects and is taken in the 2000 edition Chinese Pharmacopoeia with the drug name of helicid tablets.

N-芳基-3-(4-β-D-吡喃阿洛糖苷苯基)-5-甲酰基异唑-4-甲酰胺的合成，发明公开了具有改善中枢神经系统功能的豆腐果苷类衍生物，及其制备方法。该类化合物具有良好的镇静、安眠、抗惊厥作用。目前已以药品名&神衰果素片&被收入2000年版《中国药典》。

Our company supply raw materials and related intermediates as follows: Second dibutyryl cAMP calcium, voriconazole, terbinafine, vecuronium amines, cAMP, thiamphenicol, a chlorophenol hydrochloride esters, card network sodium phosphate tilmicosin, foscarnet, lornoxicam, Tilmicosin, Cephalosporium aspirin acid, ceftiofur hydrochloride, ceftiofur sodium, Ozagrel, ondansetron hydrochloride ketones, hydroxyurea, ticarcillin sodium, telmisartan, esmolol hydrochloride, hydrochloric acid Daguan Nikkomycin, adefovir dipivoxil, buflomedil hydrochloride, granisetron hydrochloride, warfarin sodium,-methyl gabexate acid, nicergoline, pantoprazole sodium,·, tegafur, cefepime hydrochloride, vecuronium bromide, hydrochloric acid meclofenoxate, sertraline hydrochloride, Cefonicid amine salt, aztreonam, ticarcillin, cefdinir, cefodizime sodium, sodium ferulate, colloidal pectin secretion, 2,3 - cyclopentene and pyridine, Piperacillin acid, cefetamet US-acid, hydrochloride Cefmenoxime ,3-TZ, 2 - deoxy-D-glucose, two-amidine urea benzene, sodium Cefonicid, Cefonicid intermediates, ester Cefamandole sodium, Cefalotin acid, intermediates cefpirome, cefepime sulphate, cefepime intermediate nucleus of cefepime, cefpirome nucleus, Cefamandole sodium, ceftriaxone new active ester, oxaliplatin, cyclophosphamide vary gland amines, polyene match him.

我公司供应的原料药及相关中间体为：二丁酰环磷腺苷钙、伏立康唑、盐酸特比萘芬、维库溴胺、环磷腺苷、甲砜霉素、盐酸甲氯酚酯、卡络磺钠、磷酸替米考星、膦甲酸钠、氯诺昔康、替米考星、头孢匹胺酸、头孢噻呋盐酸盐、头孢噻呋钠、奥扎格雷、盐酸恩丹西酮、羟基脲、替卡西林钠、替米沙坦、盐酸艾司洛尔、盐酸大观霉素、阿德福韦酯、盐酸丁咯地尔、盐酸格拉司琼、华法林钠、甲磺酸加贝酯、尼麦角林、泮托拉唑钠、普拉洛芬、替加氟、盐酸头孢吡肟、维库溴铵、盐酸甲氯芬酯、盐酸舍曲林、头孢尼西胺盐、氨曲南、替卡西林、头孢地尼、头孢地嗪钠、阿魏酸钠、胶体果胶泌、2，3-环戊烯并吡啶、哌拉西林酸、头孢他美酸、头孢甲肟盐酸盐、3-TZ、2-脱氧-D-葡萄糖、双脒苯脲、头孢尼西钠、头孢尼西中间体、头孢孟多酯钠、头孢噻吩酸、头孢匹罗中间体、头孢吡肟硫酸盐、头孢吡肟中间体、头孢吡肟母核、头孢匹罗母核、头孢孟多钠、头孢曲松新型活性酯、奥沙利铂、异环磷腺胺，多烯他赛。

The thesis was mainly focused on the synthesis and synthetic methods ofimidazole, chromene, triazine, isoquinolin derivatives and divided into five sectionsbased on the contents.

中文摘要：论文对咪唑、苯并吡喃、三嗪和异喹啉类化合物的合成及其方法学进行了较系统的研究，依据其内容分为五个部分。

A mild and convenient method for the synthesis of 4(3)-substituted 3(4)-nitro-1H-pyrroles and 3-substituted 4-methyl-2-tosyl-1H-pyrroles from nitroolefins and tosylmethyl isocyanide in ionic liquid 1-butyl-3- methylimidazolium bromide was developed.

本文以离子液体－溴化1-丁基-3-甲基咪唑为溶剂，采用对甲苯磺酰基甲基异腈与硝基烯反应生成4(3)-取代-3(4)-硝基-1-氢吡咯或3-取代-4-甲基-2-对甲苯磺酰基-1-氢吡咯。

Measurement of cyanide ; isonicotinic acid-pyrazolone colorimetric method ; experimental condition

氰化物测定；异烟酸—吡唑啉酮比色法；实验条件

The lower detection limit was 0.0006 mg/L Conclusion: Compared with the conventional isonicotinic acid 3-methy-1-pheny 1-5-pyrazolone spectrophotometry method, the advantages of the method are auto-sampling, rapid analysis speed and lower reagent consumption, etc.

与传统异烟酸－吡唑啉酮分光光度法相比，该方法具有自动进样、分析速率快、试剂耗量低等优点，可应用于大批量常规地表水分析。

A new corrosion inhibitor and Universal antibacterial reagent, namely, the copolymer of N-isopro-pylacrylamide and N-allyl-1-benzoyl-3-phenyl-4,5-dihydro-4-formamido pyrazole was prepared.

合成了一种新的腐蚀抑制及广谱抑菌剂：N-异丙基丙烯酰胺与N-烯丙基-1-苯甲酰基-3-苯基-4，5-2H-4甲酰胺基吡唑的共聚物PNIPAM-Co-PBPCP。

By the nucleophilic substitution reaction of 6-O-tosyl-l,2:3,4-di-O- isopropylidene-a-Z-galactopyranose (3) with some substituted 1, 2,4- triazole-3-thiols (4a ~ 4c) or 1, 2, 3,4-tetrazole-5-thiols (5a~5f), nine 6-S-(substituted triazolyl or tetrazolyl)-l,2 : 3,4-di-O- isopropylidene-a-D-galactopyranoses (6a ~ 6i) were prepared in high yields. Their structures and configurations were analyzed and established by elemental analysis, IR, NMR, MS spectra.

报道了6－O－对甲苯磺酰基－1，2：3，4－二－O－异亚丙基－α-D吡喃型半乳糖（3）与取代的3－巯基三唑或5－巯基四唑4a-4c或5a-5f的亲核取代反应，合成了9个6－S－－1，2：3，4－二－O－异亚丙基－α- D吡喃型半乳糖（6a-6i），通过元素分析，IR，NMR和MS确证了上述化合物的结构，并经分子模型计算进行了其构象分析。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了