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In lesions of the cervical spinal cord, the bulbar involvement was through extension via sensory long fiber tracts (fasciculus gracilis and cuneatus).

位于颈髓的病灶常经薄束和楔束向上延伸累及延髓

In lesionsof the cervical spinal cord, the bulbar involvement was throughextension via sensory long fiber tracts (fasciculus gracilisand cuneatus).

位于颈髓的病灶常经薄束和楔束向上延伸累及延髓

These DSs were first observed at 9 weeks in the distal part of ascending fibers that consist of gracile fasciculus and cerebellospinal-gracile nucleus and white matter of cerebellum. They extend along medulla oblongate to medulla cervix、medulla thorax、medulla lumbalis in accordance with dying-back type degeneration. The corticospinal tract were affected at 18 weeks,and thalamus、the olfactory pathway、the visal pathway、the auditory pathway were affected at 32 weeks.

这种DS从9周龄开始,首先在构成薄束路和脊髓小脑后路的上行纤维的远端区域-薄束核区和小脑白质出现,逐渐按照延髓、颈髓、胸髓、腰髓的顺序,向细胞体方向逆行性地进展。18周龄时波及到锥体路,32周龄时进一步波及到丘脑和嗅觉、视觉、听觉传导路。

We identified a novel NMO lesion in the spinal cord and medullary tegmentum extending into the area postrema, characterized by AQP4 loss in foci that were inflammatory and oedematous, but neither demyelinated nor necrotic.

我们在对脊髓和延髓背盖延伸入最后区的一个异常NMO病灶研究中证实,该病变仅表现为以AQP4缺失为特征的炎性水肿,既无脱髓鞘也无坏死。

The most commonly affected region was the mesodiencephalic junction, seen in 30 patients (46%), followed by the pontobulbar region in 26 (40%), the hypothalamic-thalamic region in 15 (23%), the basal ganglia in 12, the telencephalon in five, the cerebellum in three, and the cervical cord in three (Table 1). There was no difference in the distribution of lesions between the acute/subacute or chronic phases.

最常见的受累部位为中脑-间脑接合处(mesodiencephalic junction, MDJ),共在30例(46%)患者中发现此处受累;其次为脑桥延髓区,共在26例(40%)患者中发现此处受累;再次为下丘脑-丘脑区,共在15例(23%)患者中发现此处受累;在12(18%)例患者中发现基底节区受累;5例(8%)患者端脑受累;3例(5%)患者小脑受累;3例(5%)患者颈髓受累(表1)。

Subdiaphragamatic vagotomy plus VP group and sham operation plus visceral pain group, and each group has 6 rats.

应用免疫组化染色方法,观察各组动物Fos在巾枢延髓孤束核及胸髓的表达。

While the tissue spaces surrounding a few blood vessels wasAl and Fg positive,no Al or Fg positive cells were observed.In antemortem injurygroup,diffuse subarachnoid hemorrhage,cerebral edema,swelling or pyknotic neu-rons could be observed.The axons showed irregular swelling and disconnection at1~3h,marked swelling and disconnection at 6h,and retraction ball at 15h whichwas more remarkable at 24h after injury.The space between myelin sheaths andaxons was increased at 3~6h after injury.Tortuous and wavelike myelin sheathswhich adhered on axons incompletely,or even peeled off could be found from 15hto 24h after injury.Perinuclear lysis of Nissl bodies began at 24h after injury.Thenumber of GFAP positive cells in cerebrum and brain-stem increased significantlyfollowed by decrease,and then increased again,but the time courses of the changesin different areas of brain were not same.Al and Fg positive neural cells,mainlysurrounded blood vessels,with diffuse or peripherally distributed positive matter incytoplasm could be observed at 0.5h after injury.The number of Al or Fg positivecells and the intensity of immunoreaction increased with the time of injury.The areaof SYN positivity in medulla oblongata and pons decreased notably 3~6h afterinjury,then return to normal levels and continued to 24h after injury.

生前损伤组,可见广泛蛛网膜下腔出血,脑组织水肿,神经细胞肿胀,晚期神经元固缩;伤后1~3h见部分神经轴突不规则增粗、断裂,伤后6h断端膨大,伤后15h可见收缩球,至伤后24h更为明显;伤后3~6h可见部分神经髓鞘与轴突之间的间隙增宽,伤后15h髓鞘明显曲折,不完全附着在轴突两侧,甚至剥脱,持续到伤后24h;核周尼氏体减少在伤后24h才开始出现;同一部位的GFAP阳性细胞数目随损伤时间发生改变,先增多(最早在伤后0.5h),达到高峰后减少,其后又有增多趋势,但不同部位的GFAP阳性细胞数目增减的时间过程不尽相同,同时,大脑中的GFAP阳性细胞数目也有改变;伤后0.5h,可在脑干组织中见到Al和Fg阳性神经细胞,主要位于血管周围,阳性物在胞浆中呈弥散性分布,但部分细胞的阳性物仅分布于靠近胞膜的胞浆中而呈环状,随损伤时间延长,阳性细胞数目增多,反应强度增加;伤后3~6h,延髓及桥脑中的SYN阳性物面积减少,其后恢复到正常水平,并持续到伤后24h。

Sixty-two artificially respired rabbits were anesthetized with urethae.Intranuclear microinjection was adopted.Microinjection of TRH into Lc-Sc induced a marked increase in respiratory frequency and significant elevation of blood pressure.The above mentioned effects of TRH into Lc-Sc on RF could be blocked by preinjection of α2 or β receptor antagonist into RVLM respectively.

实验选用62只行乌拉坦静脉麻醉和人工呼吸的家兔,采用脑内核团微量注射的方法,将TRH微量注入蓝斑复合核,使呼吸频率明显增快,平均动脉血压升高;在延髓头端腹外侧区分别预注射α2或β受体阻断剂,使TRH在蓝斑复合核的呼吸增频效应明显减弱,其升压效应可被延髓头端腹外侧区分别预注射α或β受体阻断剂拮抗。

Results: The immunostaining showed that intense FOS-Li and moderate NKR-Li neurons in the superficial laminae of medullae oblongata dorsal horn and their mainly part of the distribution were overlapped. Parts of the distribution of NKR-Li were obviously overlapped by the BSI-B4 labeled primary afferent C fibers and terminals.

结果:再次于形态学上证实了NKR样阳性结构及初级传入C纤维在大鼠延髓内的分布;发现大鼠延髓后角浅层密集分布NKR样阳性结构或BSI-B4标记的C纤维阳性纤维及终末,I、Ⅱ层内可见NKR样阳性神经元、深层偶见NKR样阳性神经元;但其中极少数是c-fos阳性神经元,未发现典型的NKR/FOS双标细胞。

The neural structural relations between the chemosensitive areas of the ventrolateral medullary surface and the intramedullary nuclei were investigated by local applications of horse radish peroxidase to different parts of the chemosenstive areas separately.

采用辣根过氧化物酶组化方法对延髓腹外侧表面化学感受区与延髓内部区域之间是否存在神经结构的联系进行了探查。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。