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The normally brominated Baylis-Hillman adducts were formed as the major product at low temperature. While at room temperature or heating, the α,γand β,β-dibrominated compounds were formed as the major products using 3-butyn-2-one and methyl propiolate or propynenitrile as substrate, respectively.

贫电子炔类化合物的Baylis-Hillman反应的研究在这部分工作中我们发现在用TiBr〓或BBr〓为Lewis酸催化贫电子炔类化合物和芳香醛的Baylis-Hillman反应时，温度对反应的影响很大：当反应在低温下进行时，通常生成的是正常的β-溴代的Baylis-Hillman反应产物；而在室温或加热条件下反应，以丁炔酮为底物时，主要生成的是α，γ-二溴化合物，而以丙炔酸甲酯及丙炔腈为底物时，主要生成的是β，β-二溴化合物。

In the reasonable drug molecular design,analyzing the conformations of the substrate without three-dimension structure and confirming its active conformation are very important to illustrate the spatial shape and active site of target enzyme. The active conformation of protoporphyrinogen IX substrate of protoporphyrinogen oxidase has been established using the Distance Comparisons DISCO method. In this paper, four different conformational molecules of Protogen IX and crystal molecule of diphenylethersAF are analyzed by comparing their geometry parameters. The results show the lower energy active conformation from the DISCO model is more reasonable.

在合理药物设计方法中，当靶标酶的三维结构未知时，对其底物进行构象分析，特别是确定其活性构象，对阐明靶标酶活性中心的空间形状和作用位点具有十分重要的意义我们曾利用距离比较法确定了原卟啉原氧化酶的底物—原卟啉原IX的活性构象，本文从构象分析的角度对4种不同构象的原卟啉原IX分子与二苯醚类分子的晶体学构象进行了几何参数的比较和分析，结果进一步证实了距离比较法所确定的活性构象更为可靠

This article, based on key technique and different objective conditions in terms of geography and geology, such as soft soils, shallow water, and heavy sludge seen in ChangHong tunnel, presents features of key construction technique in ChangHong Project, such as slope stability and bottom settlement control in dry dock, cracks control and freeboard control technique respectively for element fabrication, pile foundation construction, and piles-tube connection technique, such technique like, sludge cleanup in immersion trench, and element sinking/positioning technique together with element joint (including connection to abutment and final joint).

文章根据沉管隧道工程建设的关键技术和宁波常洪隧道工程土软、水浅、淤重等客观地质地理环境条件，介绍了宁波常洪沉管隧道工程的施工技术特点，如干坞边坡稳定和管底基础变形的控制技术、本体防水混凝土管段制作的裂缝和干舷控制技术、管段江中桩基基础的施工和其与管底连接的技术工艺、管段基槽清淤和沉放定位施工技术，以及管段接头连接（包括与岸边段的连接和最终接头）的施工技术等。

This article, based on key technique and different objective conditions in terms of geography and geology, such as soft soils, shallow water, and heavy sludge seen in ChangHong tunnel, presents features of key construction technique in ChangHong Project, such as slope stability and bottom settlement control in dry dock, cracks control and freeboard control technique respectively for element fabrication, pile foundation construction, and piles-tube connection technique, such technique like, sludge cleanup in immersion trench, and element sinking/positioning technique together with element joint (including connection to abutment and final joint).

本文根据沉管隧道工程建设的关键技术和宁波常洪隧道工程土软、水浅、淤重等客观地质地理环境条件，介绍了沉管隧道工程的施工技术特点，如干坞边坡稳定和管底基础变形的控制技术、本体防水混凝土管段制作的裂缝和干舷控制技术、管段江中桩基基础的施工和其与管底连接的技术工艺、管段基槽清淤和沉放定位施工技术，以及管段接头连接（包括与岸边段的连接和最终接头）的施工技术等。

This article, based on key technique and different objective conditions in terms of geography and geology, such as soft soils, shallow water, and heavy sludge seen in ChangHong tunnel, presents features of key construction technique in ChangHong Project, such as slope stability and bottom settlement control in dry dock, cracks control and freeboard control technique respectively for element fabrication, pile foundation construction, and piles-tube connection technique, such technique like, sludge cleanup in immersion trench, and element sinking/positioning technique together with element joint (including connection to abutment and final joint).

本文根据沉管隧道工程建设的关键技术和宁波常洪隧道工程土软、水浅、淤重等客观地质地理环境条件，介绍了沉管隧道工程的施工技术特点，如干坞边坡稳定和管底基础变形的控制技术、本体防水混凝土管段制作的裂缝和干舷控制技术、管段江中桩基基础的施工和其与管底连接的技术工艺、管段基槽清淤和沉放定位施工技术，以及管段接头连接（包括与岸边段的连接和最终接头）的施工技术等。中国诺宇综合网http：//www.siaaa.com

This article, based on key technique and different objective conditions in terms of geography and geology, such as soft soils, shallow water, and heavy sludge seen in ChangHong tunnel, presents features of key construction technique in ChangHong Project, such as slope stability and bottom settlement control in dry dock, cracks control and freeboard control technique respectively for element fabrication, pile foundation construction, and piles-tube connection technique, such technique like, sludge cleanup in immersion trench, and element sinking/positioning technique together with element joint (including connection to abutment and final joint).

本文根据沉管隧道工程建设的关键技术和宁波常洪隧道工程土软、水浅、淤重等客观地质地理环境条件，介绍了沉管隧道工程的施工技术特点，如干坞边坡稳定和管底基础变形的控制技术、本体防水混凝土管段制作的裂缝和干舷控制技术、管段江中桩基基础的施工和其与管底连接的技术工艺、管段基槽清淤和沉放定位施工技术，以及管段接头连接（包括与岸边段的连接和最终接头）的施工技术等。中国论文联盟http：//www.lwlm.com

This investigation has led to my having many enemies of the worst and most dangerous kind, and has given occasion also to many calumnies, and I am called wise, for my hearers always imagine that I myself possess the wisdom which I find wanting in others: but the truth is, O men of Athens, that God only is wise; and in this oracle he means to say that the wisdom of men is little or nothing; he is not speaking of Socrates, he is only using my name as an illustration, as if he said, He, O men, is the wisest, who, like Socrates, knows that his wisdom is in truth worth nothing.

这个调查致使我结交了很多危险的敌人，也使我有时遭受很多的灾难，同时我被称之为有智慧，所以我的听众经常想象我拥有我希望在别人那里找到的智慧：但事实是，雅典的人们，唯有神才是有智慧的；那个预言他是要告诉我们人类的智慧是微不足道，他不是在说我苏格拉底，他只是用我的名字来做一个演示，正象他所说，象苏格拉底这样知道他自己拥有的智慧微不足道的人才是最有智慧的。

First, the significant of co-factor InsP6 and center water in the mechanism of auxins are explored by docking; second, the experiments that compared with the docking rusults of two situations involving fully rigid and selective flexible of active residue of the receptor TIR1 illuminate that selective flexibility docking by AutoDock4 reports more rational results, so that, AutoDock4 dockings are implemented with TIR1-Auxins; third, AutoDock4 docking by TIR1-Auxins-Aux/IAA illuminates that auxin as a molecular glue enhances the interaction between TIR1 receptor and Aux/IAA substrate by the weak interactions, such as hydrogen bond and hydrophobic interaction, furthermore, the weak interactions between receptor protein and ligands greatly influence on auxin activity of auxin ligands.

首先，通过分子对接计算研究辅酶InsP6以及中心水分子在生长素反应中的重要作用；其次，比较受体大分子完全刚性以及活性残基部分柔性的两种情况下的分子对接结果，说明AutoDock4实现了受体分子活性残基的部分柔性而使对接结果更加合理，进而使用AutoDock4方法对TIR1-Auxins体系进行对接计算；最后，对TIR1-Auxins-Aux/IAA体系进行分子对接计算，结果表明，生长素配体分子作为&分子胶水&直接与受体大分子TIR1以及底物多肽Aux/IAA形成强的弱相互作用，如氢键作用、疏水相互作用，促进了受体TIR1与Aux/IAA底物之间的结合，进而说明氢键作用和疏水相互作用等弱相互作用对于生长素分子的活性具有很大的影响。

Terms to know: Habeas Corpus Emancipation Emancipation Proclamation Fort Sumter Confederacy Union Thirteenth Amendment Ironclad ships Harper's Ferry Secession Trent Affair Conscription Uncle Tom's Cabin Battles to know: Gettysburg Shiloh Bull Run Antietam Vicksburg Chancellorsville Concepts to know Resources of Union start of war Resources of he Confederates start of war Anaconda Plan Concept of "Total War" Causes of the War Acts of protest before and during the war Lincoln's main reason for war How war affected the economy of the Confederacy How war affected the economy of the Union Other: Andersonville Fort Pillow Appomattox Court House Gettysburg Address Battlefield Medicine

条款知道：人身保护令解放解放宣言桑特堡邦联联盟第十三条修正案铁船哈珀的渡轮分裂国家特伦特事件征兵汤姆叔叔的小屋战斗知道：葛底斯堡希洛牛市安蒂特姆维克斯堡钱概念知道资源的联盟开始的战争资源Confederates开始他的战争蟒蛇计划观念的&总体战&原因战争抗议行动之前和战争期间林肯的主要原因战争如何受战争影响的经济邦联如何受战争影响的经济联盟其他：安德森维尔堡枕头阿波马托克斯法院大楼葛底斯堡演说战地医学

Hydrolysis of the mischarged amino acids in theediting reaction will rely on the proper binding and correct recognition of both mainchain and side chain of the substrate. In general, the editing active site ofLeuRS-ED has a very rigid structure with a defined stereochemistry and usesa number of conserved residues to precisely bind and recognize the misactivatedamino acids and discriminate and reject the cognate amino acid, specifically usingMet336, Asp345, and possibly Thr247 for main-chain recognition and Thr252,Met336, and Val338 for side-chain recognition.

在编校反应中错配的氨基酸的水解依赖于对底物主链和支链的适当的结合和正确的识别。ecLeuRS-ED的编校活性位点有一个非常刚性的有很精确设计的立体化学性质的结构，采用一系列保守氨基酸残基来精确结合和识别错配的非共轭氨基酸而区分排斥正确的共轭氨基酸，具体就是采用Met336、Asp345，另外可能还有Thr247对底物主链进行识别，采用Thr252、Met336和Val338对支链进行识别。