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The index case was a 5-month-old infant girl who had anisocoria from 4 weeks of age. One hour after 1% apraclonidine hydrochloride was instilled in each eye, there was blanching of the periocular skin, and the parents reported that the infant was excessively drowsy. Two hours after receiving apraclonidine, the infant was taken to the emergency department for lethargy and unresponsiveness, with bradycardia (84 beats/min), shallow respiration (40 breaths/min), and blood pressure 115/85 mm Hg. Oxygen saturation was 80% but improved rapidly to 100% when oxygen was given via a face mask. Eight hours after receiving apraclonidine, the infant had returned to normal.

指标案例是一名5个月大的女婴,她从4周大时就有瞳孔大小不等的状况;在1%的apraclonidine氯化氢徐徐滴点她的双眼后1个小时,眼眶周边的皮肤即变白,而她的家长表示她变得非常嗜睡;在使用apraclonidine 2个小时之后,该名女婴因嗜睡和无应答性,以及心搏过慢(每分钟84下)、呼吸浅弱(每分钟40次)以及血压115/85 mm Hg等症候而被送进急诊室;血氧饱和度原先为80%,在面罩给氧后迅速回复到100%,在使用apraclonidine 8个小时后,该名女婴终于回复健康状态。

The index case was a 5-month-old infant girl who had anisocoria from 4 weeks of age. One hour after 1% apraclonidine hydrochloride was instilled in each eye, there was blanching of the periocular skin, and the parents reported that the infant was excessively drowsy. Two hours after receiving apraclonidine, the infant was taken to the emergency department for lethargy and unresponsiveness, with bradycardia (84 beats/min), shallow respiration (40 breaths/min), and blood pressure 115/85 mm Hg. Oxygen saturation was 80% but improved rapidly to 100% when oxygen was given via a face mask. Eight hours after receiving apraclonidine, the infant had returned to normal.

指标案例是一名5个月大的女婴,她从4周大时就有瞳孔大小不等的状况;在1%的apraclonidine氯化氢徐徐滴点她的双眼后1个小时,眼眶周边的皮肤即变白,而她的家长表示她变得非常嗜睡;在使用apraclonidine 2个小时之后,该名女婴因嗜睡和无应答性,以及心搏过慢(每分钟84下)、呼吸浅弱(每分钟40次)以及血压115/85 mm Hg等症候而被送进急诊室;血氧饱和度原先为80%,在面罩给氧后迅速回复到100%,在使用apraclonidine 8个小时后,该名女婴终於回复健康状态。

In a four-hour appearance before the House Oversight Committee Thursday, Mr. Greenspan encountered legislators who interrupted his answers, caustically read back his own words from years ago, and forced him to admit that, at least in some ways, his predictions and policies had been wrong.

周四在众议院监管委员会历时4个小时的听证会上,议员们不时打断格林斯潘的应答,语带挖苦地复述他几年前的言论,并强迫格林斯潘承认,他当年的预判和政策至少在某种程度上是错误的。

The respondent has broken domn irretrievably and decreed that the said marriage be dissolved unless sufficient cause be shown to the cort winthin 6weeks from the making of this decree why such decree should not be made absolute.

应答者 已经不能挽回地打破 domn 而且法令被说的婚姻被溶解除非充份的因素被显示到来自这一条法令的成功因素的 cort winthin 6 weeks 为什么如此的法令不应该被做 absolute 。

The cortical component of the olivo-cortico-nuclear loop is essential for acquisition of classically conditioned nictitating membrane response learning, and eyeblink control areas in HVI are critical.

橄榄体皮质核环的皮质元件对经典制约的瞬膜应答学习是必不可少的,而HVI中的眨眼控制区也是关键的。

The dynamic changes of the number of T or B lymphocytes and the content of immunoglobulin G, IgM, IgA in peripheral blood, the number of CD〓, CD〓 lymphocyte subpopulation, T〓 cells and IgG, IgM, IgA antibody-producing cells, the ratios of CD〓 and CD〓 T cells in immune organs (thymus, bursa of Fabricius and spleen) and immune tissues (cecal tonsils and Harderian glands), the content of IgA, IgM, IgG in local fluid (tear, tracheal fluid, intestinal fluid and bile) of one-day chicks infected with chicken infectious anemia virus and CIAV-infected chicks immunized with Newcastle disease vaccine were determined respectively by immunohistochemistry, immunogold-silves and immunoenzyme staining in order to reveal mechanism of immunopathogenesis of chicks infected with CIAV and influence of immune responses of CIAV-infected chicks to ND vaccine.

中文题名雏鸡感染鸡传染性贫血病毒后免疫变化和对新城疫疫苗的应答及其免疫机理副题名外文题名 Immune changes of chicks infected with chicken infectious anemia virus and immune response and mechanism to Newcastle disease vaccine immunity 论文作者郑世民导师刘忠贵教授学科专业基础兽医学研究领域\研究方向学位级别博士学位授予单位东北农业大学学位授予日期2002 论文页码总数105页关键词鸡传染性贫血病雏鸡新城疫疫苗馆藏号BSLW /2003 /S858 /9 本项研究采用免疫组织化学、免疫胶体金及免疫酶方法,首次对CIAV感染1日龄雏鸡和CIAV感染雏鸡ND疫苗免疫及vNDV攻击后,其外周血液的T细胞、B细胞数量和IgG、IgM、IgA含量;中枢免疫器官胸腺和法氏囊,外周免疫器官脾脏及呼吸道和消化道局部粘膜免疫组织哈德尔腺和盲肠扁桃体的ANAE〓、CD4〓、CD〓T细胞、IgG、IgM、IgA抗体生成细胞数量和CD〓与CD〓T细胞比值以及泪液、气管液、肠液、胆汁的IgA、IgM、IgG含量的动态变化规律和CIAV感染对ND疫苗的免疫保护率等进行了全面系统地研究。

The experiments may contribute not only to investigating the mechanism of interaction between ldiotype and anti -idiotype T cells by which immune network are up-regulated, but also to analysing the suppressive effect of anti -idiotypic T cell or antibodies against the antigens on the activated T cells in the allo-responsiveness.

本课题选用小鼠耳后心肌移植模型,用同种抗原特异的活化T淋巴细胞免疫同系小鼠的方法,诱导免疫小鼠同种心肌移植物存活时间的延长,以此探讨免疫网络中独特型-抗独特型相互作用机理,着重分析在同种抗原诱导的免疫应答中,抗独特型T细胞和抗活化T淋巴细胞抗原抗体对同种免疫反应的抑制作用。

Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD81,LDL receptor,scavenger receptor B type I,L-SIGN,DC-SIGN and so on,may influence organism humoral immunity and the cellular immunity function in different degrees; HCV infection also may cause the reduction of quantity of organism immune cell or functional defect,low response of humoral immune response,tolerance of cellular immunity,then,the host finally transforms into chronic infection condition.

其慢性化的机制非常复杂,是由多个因素造成的,HCV因其基因高变性可以逃避宿主的免疫监视;HCV具有泛嗜性,肝外组织又可为肝组织的反复感染提供病毒来源;CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能;HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷,体液免疫应答水平低下、细胞免疫耐受,宿主最终转变为慢性感染状态。

Comparison from the Germany isolate, phocine distemper virus type Ⅱ(PDV-2) and vaccine strain, the major difference is the long signal peptide domain while the mature protein exhibit high identity, and all of the 13 serine residues, four potential asparagine glycosylation sites and two hydrophobic regions supposed to affect the fusion function are completely identical. These data supports the view that F protein is more conservative than H protein in CDV.

三、犬瘟热病毒中国分离株囊膜糖蛋白基因免疫小鼠诱发的抗体应答经一系列步骤将CDV-YZ0101株的两囊膜糖蛋白基因定向导入真核表达载体pcDNA3.1中,DNA测序和酶切分析筛选阳性重组质粒克隆pcDNA-H和pcDNA-F,以重组质粒DNA和脂质体共转染COS-7细胞,用间接免疫荧光试验证实转染的COS-7细胞的胞浆中分别表达了CDV的H和F蛋白。

The nucleus pulposus of scoliotic discs responds to exogenous stimuli by secreting interleukin-6 (IL-6) and other inflammatory cytokines.

背景数据的概要:脊柱侧凸的椎间盘髓核对分泌的白细胞介素-6和其他的炎性细胞因子的外源性刺激作出应答。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。