年龄

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

I was interested in art from a young age and by the time I was a teenager, I wanted to be an animator.

我是对艺术感兴趣从年轻年龄，并且，当我是少年的时候，我想是设计卡通者。

ObjectiveTo investigate the relationship between the extent, type and the age of patients of anisometropia and the extent as well as treating effects of amblyopia, and to provide evidence for the clinical treatment.

目的 探讨屈光参差程度、类别、治疗年龄与弱视程度、疗效的关系，为青少年屈光参差性弱视的临床治疗提供参考。

Compared with previous reports of similarly aged Singapore Chinese adults, the prevalence of myopia, astigmatism, and anisometropia was lower, whereas the prevalence of hyperopia was similar.

与前期报道的相似年龄的新加坡中国成年人相比，马来人的近视、散光和屈光参差的患病率要低，但远视的患病率相似。

Results The common anisometropia was hepermetropic. The extent of amblyopia was not related the type but to the extent of anisometropia. The effect of treatment was the younger the better.

结果 以远视性屈光参差性弱视多见，屈光参差程度越大，弱视程度越重，但弱视程度与屈光参差类型无关；儿童年龄越小，弱视治疗疗效越好。

It is the favored grape of the Anjou region of France and, although naturally a hard, acidic grape slow to mature, is made into fine sweet wines that age well for a least ten years in the bottle.

它是葡萄青睐的anjou地区和法国，尽管自然硬，酸性葡萄缓慢成熟，是制成优良甜葡萄酒年龄好了至少10年，在瓶子里。

According to the fact that dawsonite and ankerite are the authigenic minerals forming at latest in sandstone, CO2 infilling was relatively late, possibly 46.2 ± 2.1 Ma or later.

CO2注入晚于油气大规模充注，最早时间为90Ma，与研究区花岗岩、流纹岩等岩浆岩年龄相差较大。

The main paragenetic minerales are: uranophane, uranium blacks, autunite, meta-torbernite, microquartz, quartz, ankerite, calcite, fluorite, hydromica, pyrite, galena, sphalerite, and chalcopyrite.

矿化作用共可分为八个阶段，同位素研究结果表明，矿床中的铀主要来自岩浆溶液，部分轴来自围岩——侏罗系长石石英砂岩。沥青铀矿的同位素年龄为108—109百万年。

Anklet jewelry is a quite popular option with men and women of all ages in today's culture.

脚链首饰是一个男人和在今天的文化，所有年龄的妇女很受欢迎的选择。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。