干扰抑制

In nonclinical studies, normal cells appear to beable to recover from intermittent proteasome inhibition, but many types of cancercells undergo apoptosis when proteasomes are inhibited, even for a short time.

它可以选择性地抑制蛋白酶小体的苏氨酸蛋白酶活性，减少对特定细胞周期调节蛋白(IkB、p53、p27、p21等)的降解。由于这些调节蛋白的集聚，肿瘤细胞分裂周期受到干扰，细胞分裂停止，最终导致细胞凋亡。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

This dissertation introduces the history, key technology, current status of nation and internation ,and the importance of MiroSot ; describes function theory and constitutes of MiroSot resumptively firstly ; then introduces machine structure in detail including the characters and choice of electromotor and the design and facture of hull; stresses on control circuit of soccer robot including the choice of control circuit and DSPs, basic circuit of soccer robot and control algorithmic of soccer robot.a new design based on DSPs is made; lucubrate radio communication subsystem including the origin of yawp and controlled method in radio communication finally, and a emitter is made, and hard base has gained to upbuild experiment bed of MAS.

本论文首先简要地介绍了机器人足球比赛的发展历程、所涉及的关键技术和研究意义，概括地描述了MiroSot系统的构成；然后系统地研究了足球机器人机械结构的设计、电动机的选择、壳体的设计等，重点研究了MiroSot足球机器人的控制电路，包括DSPs芯片的选择、足球机器人硬件电路的设计和控制算法的编写，在此基础上研制了基于DSPs的足球机器人；最后深入研究了无线通讯子系统，包括无线通讯干扰噪声的来源及其抑制方法，无线发射器软、硬件的设计和制作，为全面建立多智能体系统实验平台奠定了基础。

The research is the first time small interfering ribonucleic acid molecules have been used to curb a viral infection in an animal.

该实验首次采用小分子干扰RNA来抑制动物体内的病毒感染。

Furthermore, inhibition of TG2 by rottlerin or by the siRNA led to accumulation of green fluorescent protein-LC3-II in autophagosomes in pancreatic cancer cells transfected with GFP-LC3 (GFP-ATG8) expression vector.

此外，抑制TG2的rottlerin或小分子干扰核糖核酸导致积累的绿色荧光蛋白- LC3 - II在autophagosomes在胰腺癌细胞转染绿色荧光蛋白LC3 （绿色荧光蛋白ATG8 ）表达载体。

Analyzing the array pattern, we show that the interference of other sectors, also to be MAI, can be effectively suppressed by the array antennas for a sectored UTRA TDD of WCDMA system.

对阵列模式进行分析，证明分扇区UTRA TDD模式的WCDMA系统能有效抑制多址干扰。

The RNAi technology can effectively inhibit the expression of lipoxygenase gene in soybean seed, decrease the activity of lipoxygenase, increase the amount of oil content in its products, improve the quality of soybeans, and create new superordinary germplasm resources of soybean.

应用RNA干扰技术可有效的抑制大豆籽粒中脂肪氧化酶基因表达，降低脂肪氧化酶活性，提高大豆油份含量，改良大豆品质，创造优良大豆种质。

The objective of this study was try to find a new avenue of breeding technique in soybean to improve the quality of soybeans and create new superordinary germplasm resource of soybeans by RNAi, which prohibits the gene expression of lipoxygenase in soybean seed.

通过RNA干扰技术抑制大豆籽粒中脂肪氧化酶基因表达，改良大豆品质，创造优良大豆新种质，探索大豆品质育种新途径。

The mechanism may be it can interference the thermotaxic center, descend the level of plasma cellular factor TNF - one of the endogenous pyrogens, inhibit the synthesis and release of central febril media PGE〓 and cAMP.

其机理可能与直接干扰体温调节中枢作用，降低血浆中作为内生致热原之一的细胞因子TNF水平，抑制中枢发热介质PGE〓、cAMP的合成释放等有关。

Simulation results have strongly verified the effectiveness of the algorithm.Fourthly, another adaptive beamforming algorithm for UCA is introduced.

仿真表明，算法能有效地抑制相干干扰，具有明显的小快拍数收敛特性，并比常规的模式平滑算法提高了阵列孔径利用率； 4。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。