帕金森病

So people attach great importance to the damage by its toxicity. The main target organ of manganese is nervous system. At the early stage, its major symptoms are neurasthenic syndrome and autonomic nerve functional disorder, and then the apparent damage to extracorticospinal tract nerves, similar to that of a Parkinson's disease.

锰的主要毒作用器官是神经系统，早期以神经衰弱综合征和植物神经功能紊乱为主，继而可出现明显的锥体外系神经受损症状，与帕金森病(Parkinson's disease，PD)症状类似，流行病学研究认为锰是PD发病的环境危险因素之一。

In recent years, rTMS has also been used as a therapeutic tool in a variety of neuropsychiatry disorders such as Parkinson disease and depression that were conceptualized in term of a dysfuction of neuronal circuits and neurons at a cellular and molecular level.

近年来rTMS更是在治疗一系列的神经精神疾患如帕金森病、抑郁等上取得了较好的效果，但其治疗机制尚不明了，而且这些神经精神疾病又被认为是神经环路和神经元在细胞及分子水平上的功能失调，因此探讨rTMS所致的磁刺激对中枢神经系统中神经元基因活性、神经介质或/和调质、结构变化等的调控作用有着重要的意义。

Objective To investigate the role of nitric oxide in neuronal damage in mice model of Parkinson′s disease.

目的 研究一氧化氮在帕金森病小鼠模型神经损害中的作用。

The mutation of Parkin gene is one of the pathogenesis of early-onset Parkinson's disease.

Parkin基因突变是早发性帕金森病患者发病原因之一。

This study was designed to analyze the parkin mutati...

为了解parkin基因突变在早发性和迟发性帕金森病患者中的情况，本文作一初步的研究。

Objective: Study on the mutations of Parkin gene in early-onset Parkinson's disease and analyze the effects of mutations on its function.

目的：研究早发性帕金森病患者Parkin基因的突变情况，并分析Parkin基因突变对其功能的影响。

Objective To investigate the relationship between polymorphisms in Parkin gene and susceptibility to sporadic Parkinsons disease.

目的 探讨Parkin基因V/L380及R/W36 6多态性与散发性帕金森病的遗传易感性之间的关系。方法以 12 0例散发性PD患者为研究对象，12 0名正常人作为对照。

Objective To explore parkin gene deletion mutations at exons 3 to 7 in Chinese familial patients with Parkinson's disease as well as the association with the clinical features.

目的 探讨中国家族性帕金森病患者parkin基因第 3～ 7外显子是否存在缺失突变，及其与该病临床特点的关系。

Objective: To investigate the mechanism of Parkinson's disease.

目的：探索帕金森病的发病机制。

The same is true for one type of Parkinson's disease tested.

同样在帕金森病的测试中也得到相同的结论。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。