帕金森病

Both ablative surgery and STN-DBS appears to be safe and efficacious for the management of advanced PD.

核团毁损术和DBS两者被证实是中晚期帕金森病安全、有效的治疗方法，能显著改善术前帕金森病患者的UPDRS运动评分，减轻左旋多巴诱发的运动波动及异动症。

At present there is no effective therapeutics to treat PD except the allopathy. The discovery of neural stem cells in the adult mammalian brain provides a new chance to effect a radical cure on PD. But how to make the limited neural stem cells proliferating enough and differentiating into the dopaminergic neurons which can repair the nigrostriatal pathway and help to eliminate the PD symptoms becomes an urgent problem.

成年动物脑内神经干细胞的发现为根治帕金森病提供了新的细胞源泉，但如何使有限的神经干细胞增殖到足够数量并转化为多巴胺能神经元，使之能够修复黑质纹状体通路，逆转帕金森病临床症状，是目前亟待解决的问题。

The administration of the drug dopa can improve lips dysfunction of parkinsonian.

本文介绍了治疗轻度至中度构音障碍的生理康复途径，药物左旋多巴可以改善帕金森病患者的唇功能失常，一些研究还显示左旋多巴能改善帕金森病患者的喉机能失常和发音。

Results The GRK5 protein level in Parkinson's disease α-synuclein transgenic mice was increased to different degrees compared with that in non-transgenic littermate control mice, and the protein and mRNA expressions of GRK5 in 9-month old A53T mutant mice were higher than those in NLC mice, but there were no significant changes in the 3 month and 6 month old A53T mutant mice.

结果 各组帕金森病α-synuclein转基因小鼠与阴性对照小鼠相比，GRK5蛋白表达水平均有不同程度的增加，并且随着转入的h-α-syn蛋白表达水平的高低而有所变化。3月龄和6月龄帕金森病转基因模型小鼠与同月龄阴性对照组小鼠相比，GRK5的mRNA和蛋白水平没有变化；而9月龄帕金森病转基因模型小鼠与同月龄阴性对照组小鼠相比，GRK5的mRNA和蛋白水平都有所增加。

Significant association between cerebrovascular lesions and neuritic Braak stage was seen in PDD but not in PD subjects without dementia.

帕金森病痴呆患者脑血管损害和神经炎Braak分期明显相关，但这种相关性在帕金森病未合并痴呆患者中却无体现。

A retrospective clinico-pathologic study of 100 patients with autopsy proven PD (including 44 cases with dementia/PDD) and 20 cases of dementia with Lewy bodies confirmed essential clinical (duration of illness, Mini-Mental State Examination/MMSE, age at death) and morphologic differences between these groups; Lewy body Braak scores and Alzheimer pathologies (neuritic Braak stage, cortical Aβ plaque load, and generalized cerebral amyloid angiopathy or CAA) were significantly higher/more severe in DLB and PDD than in PD without dementia.

一项关于100例经尸检证实为帕金森病（44例并发痴呆或帕金森病痴呆）和20例路易体痴呆的回顾性临床病理研究证实了其关键的临床表现（病程、MMSE评分，死亡年龄）和形态学差异。结果表明，路易体病和帕金森病痴呆患者的路易体Braak评分和阿尔茨海默病病理学改变较未并发痴呆的帕金森病患者更为严重。

The clinical manifestation of parkinsonism, Diagnosis and treatment

帕金森病的病因及病理。2。帕金森病的临床表现、诊断及治疗。

The invention also provides use of the antiparkinsonian animal model obtained in filtering gene targets for curing parkinsonism.

本发明还提供了获得的抗帕金森病动物模型在用于筛选治疗帕金森病的基因靶点中的用途。

Objective: To investigate the distribution of vesicular monoamine transporter (VMAT2) in PD model of C57BL mice brain and their relationships with Parkinson disease.

目的：探讨囊泡单胺转运体(VMAT2)在帕金森病小鼠模型脑组织中的分布特徵与帕金森病的关系。

The study included patients aged 30 and older who had a diagnosis of idiopathic PD of less than or equal to 5 years in duration, a baseline UPDRS Motor Function examination score of at least 10, a Hoehn and Yahr stage score less than or equal to 3, and 2 or more cardinal signs of PD, including bradykinesia, resting tremor, rigidity, or postural instability.

该实验患者为30岁及30岁以上诊断为突发性帕金森病患病5年或5年以下者，其UPDRS运动评分至少为10，按帕金森病hoehn - Yahr 分级标准至少3期，有2项或2项以上帕金森病主要症状，包括行动迟缓、静止性震颤、肌僵直、或姿势不稳定。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。