巴多

Vitamin C can interrupt the process of melanin production could have been generated to prevent further oxidation of DOPA ammonia was reduced to dopa, and can reduce serum levels of copper oxide, affecting the activity of tyrosine plum, thereby interfering with the biosynthesis of melanin, if the want to make the skin and fair complexion, we might eat more foods rich in vitamin C such as tomatoes, oranges, lemons, hawthorn, citrus and so on.

维生素C能中断黑色素生成的过程本来是可以防止的多巴氨进一步氧化减少到多巴，并能降低血清铜氧化，影响酪氨酸梅的活性，从而与黑色素的生物合成，如果干扰是想使皮肤白皙，我们可能会吃更多的食物含有丰富的维生素C，如西红柿，橙子，柠檬，山楂，柑桔等。

In term of techniques and skills: Ronaldo is the best player since Maradona (in the lot of Basten, Baggio, Romario, Stoitchkov, Hagi, Weah, Laudrup, Zidane, Bergkamp, Rivaldo Figo Nedved Raul Henry Ronaldinho and lately Kaka, Messi C.Ronaldo).

-在长期的技术和技能：罗纳尔多是最优秀的球员，因为马拉多纳（在很多巴斯滕，巴乔，罗马里奥，奇科夫，哈吉，维阿，劳德鲁普，齐达内，博格坎普，里瓦尔多，菲戈，内德维德劳尔亨利最近卡卡和罗纳尔迪尼奥，梅西角罗纳尔多）。

Forensic cognizance is found out, on May 22, 2007, lucky star company published a problem to be on the website that its manage " block ill will of gunman of forum of Ba Siji employ to slander lawyer of lucky star company states " and " lucky star offer a reward collects more evidence 1 million yuan, kabasiji faces international suit, announcement of lucky star offer a reward " the article says, many authentic evidence makes clear, block Basiji from September 2006 company of transmission of guest of forum of company service much home, rich and its are many forum gunman pretends to be user name, function of product of boast kilocalorie Ba Siji, pass allege " lucky star product is bad to use "" do not check give virus " wait for content, brand of company of bespatter luck star reachs product figure, misdirect and beguiling public, already formed libel.

法院审理查明，2007年5月22日，瑞星公司在其经营的网站上发表了题为"卡巴斯基雇佣论坛枪手恶意诽谤瑞星公司律师声明"和"瑞星悬赏100万元征集更多证据，卡巴斯基面临国际诉讼，瑞星悬赏公告"的文章称，大量确凿证据表明，自2006年9月卡巴斯基公司雇佣多家论坛、博客传播公司及其大量论坛枪手冒充用户名义，夸大卡巴斯基产品功能，并通过宣称"瑞星产品不好用""查不出病毒"等内容，诋毁瑞星公司品牌及产品形象，误导和欺骗公众，已构成诽谤罪。

Auto-immune type: also known as methyl-dopa-type, hemolytic disease can be medication from 3 months to 4 years later, on behalf of drug: a - methyl-dopa, levodopa, phenytoin, phenacetin, chlorpromazine, indomethacin, etc.

自身免疫型：又称甲基多巴型，溶血发病可在服药3个月至4年后，代表药物有：a--甲基多巴、左旋多巴、苯妥英钠、非那西丁、氯丙嗪、吲哚美辛等

The synthesis of the pentacyclic skeleton of Et-743 and the construction of the five chiral centers thereof.1. The core pentacyclic skeleton of phthalascidin was constructed with L-dopa as the starting material via thirteen steps. First, two basic synthons, the C-1 functionalized tetrahydroisoquinoline compounds 8 and N-protected Z-dopa derivative 9, were prepared from L-dopa. They were coupled via amide bond to form the dipeptide compounds 10, which were the first key intermediates. Then the primary hydroxyl groups were transformed into the corresponding amino aldehydes 11 via Swern oxidation. Followed by the intramolecular Pictet-Spengler cyclization, the pentacyclic compounds 12 were synthesized.

五环骨架的构建及五个正确手性中心的确立：1.1我们以L-多巴为起始原料，经过多步官能团保护和转化合成了基本结构单元8然后和苯丙氨酸衍生物9，通过缩合反应生成酰胺中间体10，经Swern氧化得到醛化合物11，然后再次利用分子内改良的Pictet-Spengler反应一步构建c，d两环，得到五环骨架化合物12，最后，实现了21-位羰基向氰基的转化，得到了C-1位官能化的化合物14，化合物14不但具有和Et-743一致的五环骨架，而且分子中五个手性中心立体构型也与其完全相同：其中，3，位和13，位的手性中心由原料L-多巴带入，而1，位，11，位和21，位手性中心则通过不对称诱导而确立。

Parkinson's disease is a kind of a progressive neurodegenerative disorder, which is caused primarily by selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The symptoms of PD include tremor, hypokinesia, and rigidity, caused by the depletion of dopamine in the striatum.

帕金森氏症是目前临床常见的神经退化疾病之一，目前对於帕金森氏症的药物治疗，主要是额外提供多巴胺或增加脑内多巴胺的停留时间，以减缓患者的症状，然而这些治疗方法皆无法减缓多巴胺神经细胞的持续性退化。

Treatment with dopamine and low dose bromocriptine resulted in cell death accompanied with the DNA laddering and activation of caspase-3 only in GH3D2L and GH3D2S cells, which were blunted by haloperidol, showing that dopamine-induced cell death in these cells is mediated by dopamine D2 receptors.

经多巴胺和低浓度溴隐亭处理后仅在GH3D2L和GH3D2S两种细胞中出现细胞死亡伴DNA阶梯状断裂和半胱天冬酶3（Caspase-3）的激活，而这些效应也被氟哌啶醇所抑制，说明多巴胺所致的细胞凋亡与多巴胺D2受体激活有关。

As for dopamine, it intercalates into the double helix of DNA in the concentration range of 5.00×10^(-5) to 9.00×10^(-4)mol/L. The binding constants of dopamine, adrenaline and dobuamine with DNA are determined as 1.55×10^3, 9.77×10^3 and 1.74×10^4L/mol, respectively, by electrochemical method.

对于多巴胺，在5.00×10^(-5)~9.00×l0^(-4)mol/L范围内，它与DNA之间主要为插人作用，同时，采用电化学方法测得多巴胺、肾上腺素和多巴酚丁胺与DNA之间的表观结合常数分别为1.55×10^3，9.77×l0^3和1.74×10^4L/mol。

Abstract］ objective for the purpose of scientific evaluation and improvement on unreasonable parameter of viral inactivation,the dynamics curve of time corresponding to effect by given viral inactivation factor treated to blood plasma product were analyzed.methods aimed at vesicular stomatitis virus, sindbis virus, human immunodeficiency virus, polioviruses, pseudorabies virus,encephalon-yocarditis virus; validate data of viral inactivated on pasteurization of albumin, human rabies immunoglobulin with ph 4, human immunoglobulin and human hepatitis b immunoglobulin for intravenous injection with ph 4/pasteurization,treatment on human fibrinogen and human coagulation factor ⅷ with solvent/detergent and vapor heating at 100 ℃30 min were systemic regularized respectively.the mean and standard deviation also coefficient of variation for virus survival titer in different time were stated, dynamics curve of virus inactivation were made and analyzed.results human albumin pasteurization inactivated vsv and sindbis virus,hrig low ph inactivated vsv and sindbis virus,hrig low ph inactivated hiv virus,ivig low ph/pasteurization inactivated hiv virus,ivig low ph inactivated hiv virus,hbig low ph/pasteurization inactivated vsv,sindbis and polio virus.conclusion suggestion about improvement on unreasonable parameter and standard of virus inactivation is made,cultivate target virus directly from final product by appropriate cell or method to monitoring viral safety of blood plasma product is advanced.

目的 分析血液制品特定灭活因子的时效动力学曲线，科学性地评价与改进不合理的病毒灭活参数。方法系统性整理针对水疱性口炎病毒、黄热病毒、脊髓灰质炎病毒、伪狂犬病毒、脑心肌炎病毒、人类免疫缺陷病毒，人血白蛋白采用巴氏消毒法，狂犬病人免疫球蛋白采用低ph常温孵放法，静注人免疫球蛋白、静注人乙肝免疫球蛋白采用低ph/巴氏消毒法；人纤维蛋白原、人凝血因子ⅷ采用有机溶剂/去污剂与干热法灭活病毒的验证资料，统计3批样品多个取样点的残余病毒滴度均值、标准差与变异系数，制作灭活病毒动力曲线图并进行分析。结果人血白蛋白巴氏灭活vsv与sindbis病毒，hrig低ph灭活vsv和sindbis病毒，hrig低ph灭活hiv病毒，ivig低ph/巴氏灭活hiv病毒，ivig低ph灭活hiv病毒，hbig低ph/巴氏灭活vsv、sindbis与polio病毒。结论建议改进病毒灭活验证标准与不合理的灭活参数；采用终产品样品通过合适细胞或方法直接培养目标病毒来有效监测血液制品的病毒安全性。

Often patients are given prescriptions for levodopa, or L-dopa, which is converted into dopamine by enzymes in the brain.

医生经常给患者开左旋多巴的处方，左旋多巴在脑细胞中酶的作用可以转变为多巴胺。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。