巨血小板

General symptoms such as purpure in mucous membrance and skin, bleeding of internal organs, decreasing of weight and bad mental state caused by modeling were well improved in four control groups (Chinese traditional medicine group, western medicine group, PG original formula group and PG major formula group), the peripheral PLT was increased, spleen weight and its action of phagocytosis and damage to PLT were both decreased, morrow megakaryocytes differentiation and maturation were improved and hyperplasia descended, which showed significant differences compared with the model group. Differences among the four control groups were not significant. The optimal dose ratio of PG major formula was finded out with homogeneous design software UST3.0 and multiple regression: Astragalus root 48g, Rhubarb 15g, peach kernel 1Og, Agrimony 24g.

结果：模型建立成功；中、西药对照组、紫癜颗粒核心方组与原方组小鼠对于免疫法造模所引起的皮肤粘膜紫癜、内脏出血、体重减轻、精神状态差等一般症状均有较好的改善；小鼠的外周血小板计数得到提高；脾脏均重及对血小板的吞噬破坏降低；骨髓巨核细胞分化成熟程度增高，增生活跃度降低，与模型组相比较，均有显著性差异，四个对照组之间无显著性差异，利用均匀设计UST3.0统计软件分析，进行多元逐步回归处理，筛选出紫癜颗粒核心方的最佳剂量配比为黄芪48g，大黄15g，桃仁10g，仙鹤草24g。

Results The megakaryocyte and platelet of 112 cases hemopathy marrow smear with acetal phospholipids staining were all positive, the plasmas cell in anaemia were positive, the erythroblast of aplastic anemia positive, the lipocyte in thrombocytopenic purpura positive, and the other cells all negative.

结果］112例血液病骨髓涂片缩醛磷脂染色中的巨核细胞和血小板均为阳性，贫血中的浆细胞为阳性，再生障碍性贫血中的幼红细胞为阳性，血小板减少性紫癜中的脂肪细胞为阳性，其余各种细胞均呈阴性反应。

But the role of TPO on megakaryocyte growth and development and the expression of TPO mRNA in human bone marrow are not well known.

为进一步了解TPO在巨核细胞—血小板生长发育过程中所起的作用，本文就TPO在体外培养过程中对巨核细胞生成的影响，对基质细胞以及血小板减少症患者骨髓中TPO mRNA的表达进行了研究探索。

Objective To study the roles of platelet and its regulating factors,megakaryocyte,thrombopoietin and transforming growth factor β1 (TGF-β1),in immune vasculitis in young rabbits.

目的动态观察血小板、巨核细胞、血小板生成素、转化生长因子β1(TGF-β1)在幼兔免疫性血管炎模型中的变化及作用机制。

To observe the morphological characteristics and hematopoietic function of bone marrow megakaryocyte in children patients with idiopathic thrombocytopenic purpura,and to preliminary analyse the cause and mechanism of thrombocytopenia.

本研究观察特发性血小板减少性紫癫患儿骨髓巨核细胞形态与造血功能的改变，初步分析其血小板减少的发生机制。

Objective: To explore the relationship between thrombopoietin levels and blood platelet count, megakaryocyte count in patients with thrombocytopenia and provide theoretical basis of clinical application of rhTPO.Methods: We measured blood platelet count, megakaryocyte count and the serum level of TPO in three group patients of differential diagnosis of thrombocytopenia .

目的 通过对不同类型的血小板减少患者进行血小板计数、巨核细胞计数，血小板生成素的测定，来探讨三者之间的关系及各种疾病造成血小板减少的原因，针对不同病因提出不同的治疗方案，为重组人血小板生成素的临床应用提供理论依据。

The results indicated that in the FNAC smears of mediastinal tumor, neutropilic myelocyte, neutropilic metamyelocyte, neutropilic stab granulocyte and neutropilic segmented granulocyte were observed in granulocytic series; early normoblast, polychromatic normoblast and orthochromatic normoblast were observed in erythrocytic series; and granular megakaryocyte, thromocytogenic megakaryocyte, scattered platelet and matured lymphocyte also were observed. Cell morphology and distribution in different stages were are similar to that in bone marrow smear, and these cells belong to the extra-medullary hemopoietic tissue.

结果表明：纵隔肿块的细针抽吸活组织的细胞学涂片显示粒系细胞中可见中性中幼粒细胞、中性晚幼粒细胞、中性杆状粒细胞、中性分叶核粒细胞；红系细胞中可见早幼红细胞、中幼红细胞、晚幼红细胞；并可见颗粒巨核细胞、产血小板的巨核细胞、散在血小板及成熟淋巴细胞；细胞形态及各期细胞分布与骨髓片相似，为髓外造血组织。

Objective: To test GPⅡb/Ⅲa and GPⅠb/Ⅸ specific autoantibodies of thrombocytopenic patients by MAIPA assay, evaluate the usefulness of MAIPA for the differential diagnosis of immune and nonimmune thrombocytopenia.

在血小板和巨核细胞膜表面存在大量的糖蛋白分子，它们不仅是血小板发挥功能所必需的，而且在免疫性血小板减少的发病中占重要地位。

The diagnosis of ITP is made clinically by exclusion of other causes of thrombocytopenia, the absence of splenomegaly, and the finding of normal or increased megakaryopoiesis on bone marrow examination. The nonimmune thrombocytopenia is caused by some nonimmune factors, such as acute leukemia, hypersplenism and post-chemotherapic bone marrow suppression.

特发性血小板减少性紫癜的诊断仍只是一种排除性的临床诊断，其国内诊断标准为多次化验检查血小板计数减少，脾脏不增大或仅轻度增大，骨髓检查巨核细胞数增多或正常，有成熟障碍，并且具备以下五点中的任何一点：泼尼松治疗有效，切脾治疗有效，血小板相关抗体增多，血小板相关补体增多，血小板寿命测定缩短，同时应排除继发性血小板减少症。

Objective To study the changes in bone marrow megalokaryocyte numbers, platelet function and T-lymphocyte subsets in children with idiopathic thrombocytopenic purpura after treatment and normalization of platelet count.

目的 研究特发性血小板减少性紫癜患儿经治疗血小板数量正常后的血小板功能、巨核细胞数量及T淋巴细胞亚群的变化。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。