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Expression of TGF-β and bFGF was from mesenchymal cells, macrophages and multinuclear giant cells in the granulation tissue.

肉芽组织中间质细胞、单核巨噬细胞和多核巨细胞表达TGF-β、bFGF。

Countless neutrophilic leucocytes were seen in 53 cases or 94.6%, plasma cells in 39 cases or 69.6%, reticulum cells in 34 cases or 60.7%, atypical epithelial cell in 39 cases or 69.6%, and multinucleated giant cells in 31 cases or 55.4% out of 56 cases of active phase ulcerative colitis.

在56例活动性溃疡结肠炎中,无数的嗜中性白细胞在53例(94.6%)中可见,浆细胞在39例(69.6%)中可见,网状细胞在34例(60.7%)中可见,不规则上皮细胞在39例(69.6%)中可见,多核巨噬细胞在31例(55.4%)中可见。

In contrast, in 50 cases with irritable colon in which biopsy showed normal colonic mucosa, no plasma cells or atypocal epithelial cells were seen, although reticulum cells and multinucleated giant cells were in only one case or 2.0% and countless neutrophilic leucocytes were seen in 6 cases or 12.0%.

相反,在50例过敏性结肠中,生物活检显示:正常的结肠粘液可见,而浆细胞或不规则上皮细胞并未发现,然而,网状细胞和多核巨噬细胞仅在1例中可见,无数个嗜中性白细胞在6例中可见。

For PNA selective targeting to a monocyte– macrophage compartment, we evaluated two novel delivery systems based on polymeric core-shell microspheres and autologous loaded opsonized RBC.

为实现肽核酸对单核细胞-巨噬细胞体系的选择性靶向作用,我们对基于聚合核-壳微球和自体载药调理素化的RBC这两种传导系统进行了评估。

METHODS Twelve piggies were randomly divided into two groups. There were six piggies in each group,normal temperature cardiopulmonary bypass and DHCA.

目的 探讨早期巨噬细胞的激活和核因子kappa B活性在深低温停循环肺损伤中的作用及其可能的作用机制。

Human hair keratin ; spinal cord injury ; rat ; tissue engineering ; tissue-engineered spinal cord ; connector ; morphology ; praxiology ; neuron ; axis-cylinder ; nerve fiber ; myelin sheath ; astrocyte ; oligodendrocyte ; microglia ; ependymal cell ; neural stem cells ; macrophage ; multinuclear giant cell ; lysosomal enzyme ; ubiquitin system ; suppression subtractive hybridization ; gene express ; CytohromeoxidaseⅢ; amino acid transporter system A2(Ata2); Peroxiredoxins 5(prd 5); cysteine proteinase inhibitor cystatin c

国家自然科学基金;广东省自然科学基金人发角蛋白;脊髓损伤;大鼠;组织工程学;组织工程化脊髓;桥接物;形态学;行为学;神经元;轴突;神经纤维;髓鞘;星形胶质细胞;少突胶质细胞;小胶质细胞;室管膜细胞;神经干细胞;巨噬细胞;多核巨细胞;溶酶体酶;泛素肽酶系;抑制消减杂交;基因表达;细胞色素氧化酶Ⅲ;氨基酸转运蛋白系统A2;抗过氧化物蛋白5;半胱氨酸蛋白酶抑制剂

Cinnamomea, antrocamphin A was purified from previous ethanol extraction using bioactivity-guided fractionation. As results, the antrocamphin A could significantly inhibit NO and PGE2 autacoids production in LPS-induced RAW 264.7 macrophage cells. Meanwhile, the mRNA and protein expression levels of iNOS and COX-2 were inhibited by antrocamphin A in a dose-dependent manner. Antrocamphin A also reduced the translocation of NF-κB induced by LPS, which was associated with the prevention of the degradation of I-κB, and subsequently decreased p65/p50 proteins level in the nucleus. This is the first report demostrating the A.

接著并以活性为导向的分离策略,从樟芝子实体乙醇抽出物中分离出具抗发炎活性成分antrocamphin A,续利用LPS诱导小鼠巨噬细胞(RAW 264.7)产生发炎的模式,解析antrocamphin A之抗发炎机制,结果证实antrocamphin A确可有效抑制一氧化氮自由基和前列腺素的生成,透过蛋白质表现分析得知,antrocamphin A之抗发炎活性是经由抑制一氧化氮生成酵素和第二型环氧酵素的mRNA表现,进而抑制了一氧化氮生成酵素、第二型环氧酵素和核转录因子-κB等酵素之表现。

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