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BACKGROUND: We determined the effects of levosimendan, a calcium sensitizer, on left ventricular diastolic function in patients with LV hypertrophy.

背景:确定左西孟旦,即一种钙增敏剂,在左室肥厚患者中对左室舒张功能的影响。

Left ventricular ejection fraction, percent regional wall motion of infarcted wall, cortina dysfunction score and end-diastolic volume index were calculated by left ventriculography.

经过左心室造影应用面积长轴法计算每例患者的左室射血分数,梗塞区室壁运动百分率,左心室舒张末容积指数及Cortina室壁运动不良积分。

The BMSCs were divided into six groups after repeatedly passaged: A,the BMSCs were cultured with conventional culture fluid(DMEM culture fluid+20%fetal bovine serum+2 mmol/L aminoglutaric acid amine) all the time;B,the BMSCs were cultured with conventional culture fluid+HGF(25ng/ml)+dexamethasone10~(-7M;C(HGF and Zuoguiwan induced group), the BMSCs were cultured with conventional culture fluid+ HGF(25ng/ml)+ dexamethasone10~(-7M+ 10%Zuoguiwan drug serum;D(conditioned medium and contrast serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10 % normal rat serum;E(conditioned medium and Bazhentang drug serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10 % Bazhentang drug serum;F(conditioned medium and Zuoguiwan drug serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10% Zuoguiwan drug serum.

常规培养组始终使用常规培养液(DMEM培养液+体积分数20%胎牛血清+2mmol/L谷氨酸胺)进行培养;HGF诱导组以常规培养液+促肝细胞生长因子(HGF,25ng/ml)和地塞米松10~(-7M进行培养;HGF加左归丸组以常规培养液+促肝细胞生长因子(HGF,25ng/ml)和地塞米松10~(-7/M+10%的左归丸含药血清进行培养;条件培养液加对照血清组以常规培养液+50%的条件培养液+10%正常大鼠血清进行培养;条件培养液加八珍汤组以常规培养液+50%的条件培养液+10%八珍汤含药血清进行培养;条件培养液加左归丸组以常规培养液+50%的条件培养液+10%左归丸含药血清进行培养。

1 The approach of LVB cannulated by passed retrograde across the aortic valve can be performed easily and reduce LV pre-load and LV work, as well as cardium oxygen consumption significally; 2 This LVB can improve coronary artery perfusion and cardiac function while AOMP can be maintained after LAD occlusion; 3 There has a potential impariment effect on the right ventricular function with excessive amount BFR (over 85%) during LVB, particularly in the present of myocardial ischemia; 4 Roller pump is not suited for a prolonged bypass because of significant damage to the blood system.

由此我们得出以下实验结论:经外周动脉逆行左室置管转流方法操作简便、迅速。能明显减少左室前负荷,减少左室作功,降低心肌耗氧量;能维持严重心脏缺血后的平均动脉压,改善冠脉循环灌注和左室功能,具有临床应用的可行性。85%以上转流率对缺血心脏的心功能有潜在的损害效应。以75%左右转流率较为合适。转子泵不适宜用作长时间转流。

Artery left circumflex were isolated by operation,and artery LCX thrombosis was formed using endangium rough combined with electrostimulator.

手术分离冠状动脉左旋支,以血管内膜粗糙+电刺激法形成冠状动脉左旋支血栓,检测静脉注射不同剂量reteplase后对冠状动脉左旋支血流量、栓塞再通率、心肌梗死范围、伤口失血量和末梢出血时间的影响。

Results: Thrombus within right ventricle and main pulmonary artery was detected in 6 patients, right atrium and RV enlargement was found in 19 patients, right ventricular hypokinesis was found in 21 patients, hypokinesis of interventricular septum was detected in 13 patients, MPA and right pulmonary arterial dilation was found in 22 patients, marked tricuspid regurgitation was detected in 23 patients, pulmonary hypertension was found in 23 patients.

右心异常改变者26例(包括超声直接检出血栓的6例),其中右房室增大19例;右室收缩功能减退21例;室间隔左移、左室短轴切面室间隔向左室膨突呈&D&型改变1例;室间隔运动幅度减低13例;主肺动脉及右肺动脉增宽22例;三尖瓣中量以上返流23例;肺动脉收缩压增高23例,范围在33~81mmHg (62.87±23.46 mmHg),治疗后肺动脉压明显下降,范围在21~52 mmHg (34.26±13.52 mmHg)。

The right chest pad is placed on the victim's right infraclavicular chest

右侧电极板放在病人右锁骨下方,左电极板放在与左乳头齐平的左胸下外侧部

To observe the effects of SGDP given through sublingual tablets on hemodynamics and myocardial oxygen consumption in anesthetic dogs which were operated to expose heart, we put the electro-magnetic flowmetre feeler onto the the levo of coronary artery and the root of aorta to measure the the coronary arterial blood flow and cardiac output, left ventricular pressure was observed by the pipe into the left ventricle of the heart.

为观察舒冠滴丸舌下给药对麻醉犬心脏血流动力学及心肌耗氧量的影响,实验采用开胸暴露心脏,于冠状动脉左旋支及主动脉根部放置电磁流量计探头,分别测冠脉血流量和心输出量。左心室插管测左室内压。

The cyclic variation of integrated backscatter and echo intensity of three different myocardial regions perfused by left anterior descending coronary artery, left circumflex coronary artery and right coronary artery (on the frozen frame of parasternal short-axis image,those position were approximately at the 12, 4 and 8 o'clock direction to the center of the left ventricle, respectively) were measured with HP-5500 ultrasonic system and DFY ultrasonographic quantitative analysis system.

在35例急性心肌梗死患者发病2周内,用HP-5500型超声诊断仪和DFY型超声图像定量分析诊断仪,在胸骨旁左室乳头肌短轴切面,分别测量冠状动脉左前降支、左回旋支和右冠状动脉支配区域心肌组织(分别相当于左室乳头肌短轴切面上12、4、8点的位置)的IB和EI心动周期变化幅度值,以CVIB和CVEI值≤同一切面三个不同部位中最高值的1/2作为诊断心肌梗死的标准,部分病例与冠脉造影结果对比。

We studied conscious dogs instrumented to measure LA pressure, LV pressure, and 3 LV diameters.

我们以神志清醒的狗为研究对象,测量左房压、左室压和左室直径。

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