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This study was purposed to investigate the possible side effects of L-asparaginase in the treatment of patients with acute lymphoblastic leukemia and to explore the corelation of these side effects at different therapeutic stages by means of retrospective analysis, so as to reduce the incidence of side effects and improve the safety of chemotherapy and the long-term survival of patients.

本研究采用回顾性方法分析左旋门冬酰胺酶在儿童急性淋巴细胞性白血病治疗过程中可能发生的副作用,以探索L-ASP副作用的发生与患儿所处治疗阶段的关系,以便采用有效的监测手段减少副作用的发生,提高化疗安全性及患儿的长期存活率。

The research indicates there is a large left-lateral movement trend in the eastern China, which covers nearly a half of the area of Chinese mainland and affects the crustal movement in the entire eastern China and its adjacent areas. It is considered that the present-day coastline of China seas is just resulted from such a left-lateral movement, and Stype coastline will be more curved in the future.

研究表明:中国东部的地壳运动存在着一个大的左旋运动态势,其范围覆盖近一半的中国陆地面积,影响着中国整个东部和周边区域的地壳运动,中国东部现今的海岸线形态可能很大程度上归因于这种地壳运动,而且中国海岸线的"S"形曲线将会随着地壳运动变得更加弯曲。

Combined with GC-MS and GC-FTIR analysis, experimental result showed that bio-oil produced from cellulose mainly composed of LG and HAA, bio-oil from xylan mainly composed of acid compounds and aldehyde compounds, while bio-oil from lignin composed of phenol compounds with different functional groups such as methoxyl group, alkyl group and hydroxyl group. We research the thermal stability of the main product.

结合GC—MS、GC—FTIR分析技术对生物油的组分进行了分析,得出了纤维素热裂解生成的生物油以左旋葡聚糖和乙醇醛为主,木聚糖热裂解得到的生物油主要为酸和糠醛等,木质素热裂解生成的生物油的主要成分苯酚类化合物,并分析了各主要产物的热稳定性。

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): A randomised, double-blind, parallel-group trial, Incidence of neural tube defects in the leastdeveloped area of India: A population-based study,Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: The EORTC 22845 randomised trial

文章摘要:雷沙吉兰作为左旋多巴的辅助用药治疗帕金森病和运动波动患者(LARGO研究。雷沙吉兰每日1次辅助治疗的持久影响):一项随机、双盲、平行分组试验,神经管缺陷在印度最不发达地区的发病率:一项基于人群的研究,早期和晚期放疗对成人低分级星形细胞瘤和少突神经胶质细胞瘤的长期疗效:EORTC22845随机试验

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

There was a good correlation between Ptw,AVCtw,MVOtw,PTV,PUV,UntwR and age.2.Assessment of left ventricular twisting and untwisting of DCM patients19 DCM patients(range 18-80 yr,mean age 50.52±17.52 yr,2 females) and 21 age- and sex-matched normal controls(range18-80 yr,mean age 49.05±16.94 yr,5 females) were enrolled into this study.Then DCM patients were divided into two groups:E/A<2 group and E/A>2 group.The routine echo showed the left ventricle dilated and EF decreased.The results show that LV rotation degree, rotation velocity at baseline and apex were irregular changeable with the cardiac cycle;the rotation direction was clockwise at the base and counterclockwise at the apex,and are combined to yield a systolic counterclockwise twisting as seen from the apex,but the rotation at the basal and apex were the same direction in some patients.

扩心病患者左室扭转及解旋特征的研究选择扩张型心肌病(Dilated Cardiomyopathy,DCM)组患者19例(男性17例,女性2例,年龄18~82岁,平均50.52±17.52岁),健康体检者21例(男性16例,女性5例,年龄18~80岁,平均49.05±16.94岁)作为对照组,扩心病患者按照E/A分为E/A<2、E/A>2两个亚组,结果显示:常规超声显示DCM组LVDd值增大,EF值减小;DCM患者左室心底部与心尖部心肌旋转角度、旋转速度随心动周期变化曲线明显紊乱;与正常组比较,DCM患者左室整体扭转角度和速度分别为(6.49±1.82)°、(67.84±15.60)°/s,较正常人显著减低P<0.01左室舒张末及收缩末扭转角度DCM患者较正常人显著减低(P<0.01,左室舒张末及收缩末时间在DCM-E/A>2组较正常人及DCM-E/A<2组显著缩短P<0.01DCM患者左室解旋速度较正常人亦显著减低(P<0.01,左室功能轻中度减低(DCM-E/A<2)患者解旋率[(0.29±0.07)%]较正常人[(0.42±0.11)%]明显减低,但当左室功能重度减低(DCM-E/A>2)时左室解旋率[(0.63±0.35)%]较正常人反而增加;左室整体扭转角度、舒张末扭转角度、收缩末扭转角度、解旋与左室射血分数未见明显相关性。3。

Since the enhanced contraceptive action of copper-bearing intrauterine device is commonly attributed to copper ions released as a result of copper corrosion, this thesis focused on the investigation of various factors probably affecting the corrosion behavior of copper in the case by in vitro measurements.

为配合各种新型含铜宫内节育器[如含消炎痛VCu IUD、Tcu IUD、γ型IUD及含左旋18-甲基炔诺酮的Cu IUD]的研制与临床应用,探索对避孕起关键作用的铜在各种情况下的腐蚀行为及影响因素,本文对几种新型Cu IUD在宫腔内可能涉及的腐蚀类型及影响因素进行了研究。

Now two NASA scientists studying meteorites older than our planet have found a majority of left-handed amino acids, suggesting that our solar system has always had a preference for southpaws.

现在两个美国航空航天局的科学家在研究比地球更久历史的陨石的时候,发现了大部分的左旋氨基酸,这表明我们的太阳系一直钟情于左撇子。

The comparison between the two results shows that over fluctuating mountains two-pass DINSAR with external DEM might obtain better results than three-pass DINSAR method and the fault along the south side of Taiyang lake formed from the Ms8.1 earthquake is left-lateral.

结果表明:在地形起伏大的高山地区,采用外部DEM的两路差分方法可以取得更好的结果;昆仑山地震造成的太阳湖南侧断裂带为左旋走滑。

In addition, the activities of Tan-lu fault (two times of left-lateral strike-slip in Mesozoic, extension from later Jurassic to Eogene and thrusting during Neogene) have an important influence on basin type, tectonic framework, sequence-filling succession, and formation of different types of tectonic belts in Hefei basin during Mes-Cenozoic.

郯庐断裂中生代的两次左旋走滑、晚白垩-古近纪时期的伸展运动及新近纪以来的逆冲活动对合肥盆地中新生代的盆地类型、构造格架、沉积充填序列以及不同类型构造带的形成等均具有重要的影响和控制作用。

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The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因,如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务,你就做你的事好了。

Who is in possession of this?

这是谁的?