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Methods 104 patients with severe heart failure were divided into two groups. The control group was treated with routine treatment (digitalis,diuretic and distend the blood-vessel) combined with Imidapril (group A,n=52). The treatment group was treated with routine treatment (digitalis,diuretic and distend the blood-vessel) combined with Bisoprolol and Midapril (group B,n=52). The course of treatment was 12 to 16 weeks. Before and after treatment,the changes of heart function,LVEF,LVESD,heart rate and blood pressure were observed.

对104例重度心力衰竭患者随机分成两组:对照组52例,予以常规用药及咪达普利等药物治疗;治疗组52例,在常规用药基础上加用比索洛尔治疗,疗程12~16周,观察治疗前后心功能、左室射血分数、左室舒张末内径、左室收缩末内径、心率、血压等指标的变化。

According to the echocardiography,enlarged internal diameter of left ventricle was found in 8 patients and short-axis fractional shortening of left ventricle 5% in 3 patients.Six out of the above 8 patients presented with shortening of accerlerating time,decreasing of accerlerating time/right ventricular ejective time value and moving forward of spectral peak in different degrees.All patients were given antianginal drugs such as β-recepter blockers,nitrate preparations and part by angiotensin converting enzyme inhibitor,diuretics and digoxin,The illncss of 29 patients were gradually controlled within one week.Three patients with AD were complicated by acute left heart failure.No obvious changes in FS of left ventricle were found on echocardiography by bed.

测量肺动脉瓣口血流频谱,左心室内径增大的8例中有6例出现不同程度的血流加速时间缩短,血流加速时间/右心室射血时间比值减小,频谱峰值前移。31例均给予β受体阻滞剂、硝酸酯类等抗心绞痛治疗,部分给予血管紧张素转换酶抑制剂、利尿剂和地高辛,其中29例在1周内卧位型心绞痛逐步得到控制。3例卧位型心绞痛发作时合并急性左心衰竭者,在床旁观察超声心动图,发现左心室短轴缩短率无显著变化,给予利尿剂、减轻前后负荷等治疗,急性左心衰竭得以纠正。

And David was the father of Solomon by the wife of Uri'ah, 7 and Solomon the father of Rehobo'am, and Rehobo'am the father of Abi'jah, and Abi'jah the father of Asa, 8 and Asa the father of Jehosh'aphat, and Jehosh'aphat the father of Joram, and Joram the father of Uzzi'ah, 9 and Uzzi'ah the father of Jotham, and Jotham the father of Ahaz, and Ahaz the father of Hezeki'ah, 10 and Hezeki'ah the father of Manas'seh, and Manas'seh the father of Amos, and Amos the father of Josi'ah, 11 and Josi'ah the father of Jechoniah and his brothers, at the time of the deportation to Babylon. 12 And after the deportation to Babylon: Jechoni'ah was the father of She-al'ti-el, and She-al'ti-el the father of Zerub'babel, 13 and Zerub'babel the father of Abi'ud, and Abi'ud the father of Eli'akim, and Eli'akim the father of Azor, 14 and Azor the father of Zadok, and Zadok the father of Achim, and Achim the father of Eli'ud, 15 and Eli'ud the father of Elea'zar, and Elea'zar the father of Matthan, and Matthan the father of Jacob, 16 and Jacob the father of Joseph the husband of Mary, of whom Jesus was born, who is called Christ.

达味由乌黎雅的妻子生撒罗满,撒罗满生勒哈贝罕,勒哈贝罕生阿彼雅,阿彼雅生阿撒,阿撒生约沙法特,约沙法特生约兰,约兰生乌齐雅,乌齐雅生约堂,约堂生阿哈次,阿哈次生希则克雅,希则克雅生默纳舍,默纳舍生阿孟,阿孟生约史雅,约史雅在巴比伦流徙期间生耶苛尼雅和他的弟兄们,流徙巴比伦以后,耶苛尼雅生沙耳提耳,沙耳提耳生则鲁巴贝耳,则鲁巴贝耳生阿彼乌得,阿彼乌得生厄里雅金,厄利雅金生阿左尔,阿左尔生匝多克,匝多克生阿歆,阿歆生厄里乌得,厄里乌得生厄肋阿匝尔,厄肋阿匝尔生玛堂,玛堂生雅各伯,雅各伯生若瑟,玛利亚的丈夫;玛利亚生耶稣,他称为基督。

And after the deportation to Babylon: Jechoni'ah was the father of She-al'ti-el, and She-al'ti-el the father of Zerub'babel, 13 and Zerub'babel the father of Abi'ud, and Abi'ud the father of Eli'akim, and Eli'akim the father of Azor, 14 and Azor the father of Zadok, and Zadok the father of Achim, and Achim the father of Eli'ud, 15 and Eli'ud the father of Elea'zar, and Elea'zar the father of Matthan, and Matthan the father of Jacob, 16 and Jacob the father of Joseph the husband of Mary, of whom Jesus was born, who is called Christ.

阿左尔生匝多克,匝多克生阿歆,阿歆生厄里乌得,厄里乌得生厄肋阿匝尔,厄肋阿匝尔生玛堂,玛堂生雅各伯,雅各伯生若瑟、玛利亚的丈夫,玛利亚生耶稣,他称为基督。

Objective To investigate the curative effect of left ventricular hypertrophy with uretic indapamide, Methods 96 patients wiht LVH were divided into two groups, 50 patients in A group were treated with indapamide 2,5~5mg/d, and 46 patients in B group with nifedipine 20~60mg/d for 12 months, Results Blood pressure、interventricular septum thickness、left ventricular posterior wall thickness、left ventricular mass index and left ventricular ejection fraction in all cases were improved after treatment, A group was better than B in LVEF, Conclusion Both indapamide and nifedipine can regress LVH, and improve left heart function

目的 观察新型噻嗪类利尿剂吲达帕胺逆转左心室肥厚的效果。方法 96例高血压LVH患者,分别给予吲达帕胺(A组,50例)2,5~5mg/d和硝苯地平控释片(B 组,46例)20~60mg/d持续12个月治疗,观察治疗前后血压及左室结构变化。结果两组治疗前后血压、室间隔厚度、左心室后壁厚度、心室重量指数和左心室射血分数均有改善(P<0,05~0,01),A组在改善LVEF方面优于B组(P<0,05)。结论吲达帕胺具有与硝苯地平类似的逆转LVH作用,有明显改善左心功能作用。

Methods: Randomly divided 80 cases with chronic cardia failure into two groups, regular therapy group and bisoprolol group with 40 cases per group. Regular anticardiac failure therapy, including cardiac and diuretic therapy, was employed to patients in regular therapy group; while the combined therapy of regular therapy and bisoprolol was employed to patients in bisoprolol group. Compared the heart rate, left ventricular diastolic dimension, left ventricular systole dimension, left ventricular ejection fraction before and after therapy and efficiency of both groups.

80例慢性心力衰竭患者随机分为两组,常规治疗组40例,采用强心、利尿等抗心力衰竭常规治疗,富马酸比索洛尔治疗组40例,在常规抗心力衰竭治疗的基础上加用富马酸比索洛尔治疗,对两组临床疗效及治疗前、后心率、左心室舒张末内径、左心室收缩末内径及左心室射血分数的变化进行比较。

Methods The rat models of heart failure were established by left anterior descending coronary artery deligation. After 6 w, 24 surviving rats were divided into sham,model and Ramipril groups at random,8 rats in each,and were treated with medicines by intragastric administration respectively. At 10 w, left ventricular enddiastolic pressure, left ventricular systolic pressure,+dp/dtmax anddp/ dtmaxof left ventricular pressure were measured.

结扎大鼠左冠状动脉前降支并饲养6 w的16只存活大鼠,随机分为模型组及雷米普利组,每组8只,另取8只大鼠为假手术组,连续灌胃给药4 w后测定大鼠血流动力学参数,ELISA方法检测血清及左心室非梗死区AngⅡ的含量,RTPCR 法测定左心室非梗死区心肌组织AT1R mRNA表达水平,Masson染色观察非梗死区心肌胶原的沉积。

Methods 80 patients with chf were divided randomly into regular treatment group treated with diuretic+digoxin+acei, and bisoprolol treatment group treated with regular treatment plus bisoprolol. all the patients were followed up for twelve months and observed the changes of homodynamic, internal diameter of left ventricle, lvef and 6-minutes walk test.

80例慢性心力衰竭患者随机分为常规治疗组(利尿剂+地高辛+acei)和比索洛尔治疗组(在常规治疗基础上加用比索洛尔),疗程12个月,观察两组治疗前后血流动力学、心功能分级左心室射血分数、左心室内径及6min步行试验、左心室射血分数、左心室内径的变化。

Their hearts were cannulated via aorta and mounted on a Langendorff apparatus and perfused retrogradely. Single midmyocardial cells were isolated enzymatically from rabbit left free wall, I were recorded by using patch clamp techniques in the whole cell configuration before and after perfusiong of 10^(-6)mol/L and 10^(-5)mol/L ibutilide solution 10^(-6 group and 10^(-5) group.

新西兰纯种大耳白兔60只,取其心脏行Langendorff灌流,以酶解法分离出单个左心室中层心肌细胞,以10^(-6)mol/L(10^(-6)组)及10^(-5)mol/L(10^(-5)组)伊布利特外液灌流正常左室前壁中层细胞,以膜片钳技术记录I的活性,并与正常对照组进行比较。

objective to evaluate the effect of urapidil on the treatment of congestive heart failure.methods thirty patients with congestive heart failure were included in the study.urapidil was given by intravenously guttae at 50mg 5~7days.results systolic blood pressure and l dbp were decreased and sao2 and cardiac output were increased after treatment.conclusion intravenous urapidil produces acute hemodynamic benefit in patients with congestive heart failure.

目的 观察利喜定治疗充血性心力衰竭的临床疗效。方法 30例充血性心力衰竭患者,先以利喜定12.5 mg稀释于20 ml生理盐水中于3~5 min内静脉注射,继以利喜定50 mg、多巴胺20mg加于250 ml液体中静滴,每日1次,滴速为利喜定100~400 μg/min,连用5~7 d。结果利喜定可显著降低收缩压、舒张压,升高血氧饱和度、左室射血分数,不引起反射性心率增快。结论利喜定治疗各种原因引起的充血性心力衰竭,可有效改善患者的临床症状和血流动力学指标。

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