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ABSTRACT Objective: To determine galanthamine in human plasma by a HPLC-MS method, and to study the pharmacokinetic and bioequivalence of Galanthamine Hydrobromide Orally Disintegrating Tablets in human.

目的:建立人血浆中加兰他敏的高效液相色谱-质谱测定方法,用于研究氢溴酸加兰他敏口腔崩解片的人体药代动力学和生物等效性。

The rude drugs and their praeparatum stability meet the new medicine requirement by stability studies. At indoor temperature, their characters, discriminations, quantity difference, water content, disintegration time, contents and the hygiology index have no obvious variety.

对三批原料药及制剂进行了长期稳定性及加速稳定性考察,结果表明,该原料药及制剂在室温及加速条件下,性状、鉴别、装量差异、水份、崩解时限、含量、卫生学指标均无明显变化,符合质量标准草案的各项规定,证明该原料药及制剂稳定性符合新药要求。

Precise focusing on the iris, low pulse energies and single pulse shots might minimize this risk. It may not be wise to utilize the Nd: YAG laser to enlarge an iridotomy.

在瞳孔缘至虹膜根部中外1/3处行Nd:YAG激光击射,冲击波本身未对小梁结构造成损伤,而在术后的房角沉积物吞噬清除过程中,会出现游走的小梁内皮细胞,并可见其变性及自溶崩解征象。

TEM observation showed that there was high degree of edema in hippocampal neurons, karyopyknosis or collapse, and mitochondrial swelling.

透射电镜观察,海马神经元高度水肿,核固缩或崩解,线粒体肿胀。

It was showed that throughout the nuclear division, nuclear membrane did not disintegrate,lamina always existed; But only one lamin peptide (similar to lamin B in higher eukaryotes) was expressed during division,ant its expression quantity changed according to the progress of division: in interphase, lamin was constant; when entering G1 phase, lamin increased sharply; then, increased slowly untill division finished.

结果表明:在整个核分裂过程中,核膜不崩解,核纤层结构一直存在;但随着分裂的进展,始终只有一种成分(类似于高等生物lamin B )的表达;其表达量随着分裂时相的推移而变化:间期时,比较恒定,进入G1期时明显增加;以后不断略有增加,直到分裂完成。

It was proved that low concentration Fe2+ can acce lerate its growth and development,but high Fe2+may lead to seedlings defor mity, make the cells become small and the seedlings divide into monospores again and again.

结果表明,低浓度的 Fe2+能促进其生长发育;而高浓度的Fe2+可以导致苗大量畸变,细胞变小,苗反复崩解成单孢子。

The influence of the use level of base and monochloroacetic acid on the degree of substitution in CMS,the influence of DS and H/Na(ratio of free and salified carboxylic acid in CMS)on swelling and disintegrating of CMS have been discussed.

考察了碱和一氯乙酸用量对CMS取代度的影响及DS和CMS中游离羧基和成盐羧基比对崩解剂吸水溶胀性能的影响。

Results:The degenerative changes of articular cartilage in the manipulation group and the sodium hyaluronate group,such as vacuolar degeneration of cytoplasm,decreased quantity and degraded function of orginele,pycnosis of nuclear and necrosis even disintegration of cell,are lesser than that in the group without treatmnet.

结果:手法干预组和透明质酸钠组软骨细胞发生胞浆空泡化,细胞器数量减少,功能减退以及细胞核固缩甚至细胞坏死崩解等退变现象的程度较空白对照组轻,手法组与透明质酸钠组相当。

Results: Of all the semen samples, 8 were HCMV positive, 4 HSV-Ⅱ positive, but none were both HCMV and HSV-Ⅱ positive. HCMV late antigens were positively and HCMV early antigens negatively expressed in the spermatogenic cells of the 8 HCMV positive cases. In the 4 HSV-Ⅱ positive cases, 3 were positively and 1 weakly positively expressed. In the semen of the 12 positive cases were found large numbers of immature spermatogenic cells, with different manifestations of apoptosis, such as chromatin pycnosis, vacuoles, damaged nuclear membrane, and apoptotic bodies, but without virus infection-induced specific morphological alteration.

结果:83例精液样本PCR检测HCMV阳性8例,HSV-Ⅱ阳性4例,未发现2种病毒同时阳性病例。8例HCMV阳性病例ICC标记生精细胞HCMV晚期抗原均见阳性表达,HCMV早期抗原均为阴性表达;4例HSV-Ⅱ阳性病例ICC标记生精细胞3例阳性表达,1例弱阳性。12例病毒阳性病例均发现较多未成熟生精细胞,并有不同程度的核染色质固缩、出现空泡、核膜破损、核崩解、凋亡小体等凋亡现象,但未能找到病毒感染的特异性形态学改变。

As slaking characteristics directly affect the stability of the slope and design of anchoring and other supports.

布形态、崩解特性直接关系到边坡整体稳定性和支护措施的方案设计。

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