尿酸酶

The research was conducted to observe the effect of hypoxanthine and a uricase inhibitor on the rat＇s serum uric acid levels in order to establish a new, experimental pathological model of the rat＇s gout.

目的：观察次黄嘌呤、尿酸酶抑制剂对大鼠血清尿酸水平的影响，拟建立一种新型实验性大鼠痛风病理模型。

MethodsThe same dosage of hypoxanthine, different uricase inhibitor are used singly or combined to replicate hyperuricemia model, inspect the uric acid in serum at different periods of time.

方法采用相同剂量次黄嘌呤，不同剂量尿酸酶抑制剂单次和连续给予复制代谢性高尿酸血症模型，测定造模后不同时段大鼠血尿酸值。

AIM To determine the optimal doses of hypoxanthine and uricase inhibitor oxonic acid potassium salt for establishment of hyperuricemia rat model, and provide experimental evidence to prepare continual hyperuricemia and gout animal model.

目的 确定次黄嘌呤与尿酸酶抑制剂氧嗪酸钾伍用制备高尿酸血症大鼠模型的合适剂量，为制备持续性高尿酸血症及痛风大鼠模型提供实验依据。

Hypoxanthine and a uricase inhibitor were combined into the model drug to work out the rat＇s animal model for hyperuricemia. A comparison was made between the effect of hypoxanthine and that of the model drug on the subject＇s serum uric acid levels. Also, such factors as the dose effect and time effect of the model-building drug were investigated.

采取合用次黄嘌呤和尿酸酶抑制剂为模型药物，制备一种尿酸生成增多型大鼠高尿酸血症动物模型，比较了单用次黄嘌呤及合用尿酸酶抑制剂对受试动物血清尿酸水平的影响，并对造模药物的量效、时效关系等因素进行了考察。

Objective To observe the fluctuation of uric acid in serum on mouse after replicating model by using hypoxanthine and uricase inhibitor. Make certain the most proper approach and solvent for using uricase inhibitor.

目的 本实验考察次黄嘌呤、尿酸酶抑制剂复制大鼠代谢性高尿酸血症模型，观察造模后受试动物血清尿酸的变化，以确定尿酸酶抑制剂造模的最佳造模途径和溶剂。

Objective To analyse the clinical application quality of four kinds of uricase reagents:dry simple reagent of Changzheng company;liquid double reagent of Shanghai Kehua;liquid double reagent of Shanhai Shennergy-Diasys;liquid double reagent of Beijin Leadman.

目的 了解不同厂家四尿酸酶试剂即长征公司尿酸干粉单试剂、上海科华公司尿酸液体双试剂、上海申能公司尿酸液体双试剂、北京利德曼公司液体尿酸双试剂的临床应用质量方法对不同厂家尿酸试剂的精密度、线性、回收试验、干扰试验的比较以及试剂稳定性的观察。

Uricase inhibitor was given subcutaneously by lanolin mixed with olefin in acute animal model with Hyperuricemia on rat, which has the characters of high uric acid and maintaining a long time.

以羊毛脂石蜡油（质量比3：2）为溶剂配制尿酸酶抑制剂，采用皮下注射的方法造模，所复制的大鼠代谢性高尿酸血症模型具有血尿酸值高、维持时间长的特点。

In this experiment, BSA and chitosan are taken as cross-linking reagents, and nanoparticles gel and uricase are cross-linked on egg membrane.

本研究将改性纳米SiO_2凝胶和尿酸酶通过交联剂固定于蛋膜上，将酶膜紧贴于铂盘电极表面，然后以自制铂片电极为对电极、甘汞电极为参比电极，组成三电极体系，测定体液中尿酸的浓度。

Methods The intestine tract and blood vessel of rats were perfused circularly with intestinal tract perfusate or blood vessel perfusate with uric acid 140 mgL^(-1), respectively. The content of uric acid in perfusate was measured by the method of uricase and peroxide enzyme.

大鼠肠道、血管分别用含尿酸140mgL^(-1)的血管灌流液和肠灌流液循环灌流，尿酸酶及过氧化物酶法测定灌流液中的尿酸含量。

The uricase is a kind of enzyme in the purine degeneration pathways of organism, the uric acid can be oxidated in allantoin, CO2 and H2O2, human does not have the uricase, therefore the uric acid accumulates in the vivo clinical organism such as the pathological change like gout.

摘要］ 尿酸酶是生物体内嘌呤降解代谢途径中一种酶，尿酸氧化生成尿囊素、CO2和H2O2，人体中没有尿酸酶，因此尿酸在体内的积累会出现临床机体的病变如痛风。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。