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Initial stage of disease of acerbity blood of high make water can not have any symptoms, but the part can evolve and cause acute arthritis, chalkstone, kidney stone and uric acid nephrosis. The content that 3 health teach 3 · 1 balanced diet, reducing acid of make water of tall purine food is the final result that purine metabolizes, fructose is absorbed can bring about acid of nucleotide of purine of the gland inside body to produce increase too much, promote make water to be generated acerbitily then, reason should be fed less contain the food with much fructose, the intake of daily purine should 50 Mg.

高尿酸血症初期可无任何症状,但部分可演变而诱发急性关节炎、痛风石、肾结石及尿酸肾病。3健康教育的内容3·1均衡饮食,减少高嘌呤饮食尿酸是嘌呤代谢的最终产物,果糖摄入过多可导致体内腺嘌呤核苷酸产生增多,进而促进尿酸的生成,故应少食含果糖多的食物,每日嘌呤的摄入量应50 mg。

In part 1, a practical one-step RP-HPLC method thatcan simultaneous determine hypoxanthine, xanthine, uric acid, allantoin and creatinine in blood and urine was established.

人类高尿酸血症多为肾脏排泄尿酸减少的类型,而现有的建模方法在升高血尿酸的同时,也使尿尿酸含量显著增高。

Hypoxanthine and a uricase inhibitor were combined into the model drug to work out the rat's animal model for hyperuricemia. A comparison was made between the effect of hypoxanthine and that of the model drug on the subject's serum uric acid levels. Also, such factors as the dose effect and time effect of the model-building drug were investigated.

采取合用次黄嘌呤和尿酸酶抑制剂为模型药物,制备一种尿酸生成增多型大鼠高尿酸血症动物模型,比较了单用次黄嘌呤及合用尿酸酶抑制剂对受试动物血清尿酸水平的影响,并对造模药物的量效、时效关系等因素进行了考察。

Objective To observe the fluctuation of uric acid in serum on mouse after replicating model by using hypoxanthine and uricase inhibitor. Make certain the most proper approach and solvent for using uricase inhibitor.

目的 本实验考察次黄嘌呤、尿酸酶抑制剂复制大鼠代谢性高尿酸血症模型,观察造模后受试动物血清尿酸的变化,以确定尿酸酶抑制剂造模的最佳造模途径和溶剂。

A method of screening serum of patients of gout and hyperuricemia includes checking purine compound content of xanthine and hypoxanthine in serum to be tested, confirming that serum to be tested is serum of gout patient if xanthine content of 1.00-2.35 mg / L and / or hypoxanthine content of 4.1-16.00 mg / L are contained in serum to be tested and confirming that serum to be tested is serum of hyperuricemia patient if xanthine content of 0.20-1.20mg/L and / or hypoxanthine content of 1.30-3.50mg/L are contained in serum to be tested.

本发明所提供的筛查痛风疑似患者及高尿酸血症疑似患者血清的方法,是检测待测血清中包括黄嘌呤和次黄嘌呤在内的嘌呤化合物的含量,如待测血清中黄嘌呤含量为1.00-2.35mg/L,和/或次黄嘌呤含量为4.1-16.00mg/L,则待测血清为痛风疑似患者血清;如待测血清中黄嘌呤含量为0.20-1.20mg/L,和/或次黄嘌呤含量为1.30-3.50mg/L,则待测血清为高尿酸血症疑似患者血清。

Methods The adsorbing effect of montmorillonite was observed in vitro and the effect of decreasing serum concentration of uric acid was studied on acute hyperuricemia model mice. The concentration of uric acid was measured by the reduction method of phosphotungstic acid.

用离体实验研究蒙脱石对尿酸的吸附作用;用小鼠高尿酸血症模型研究蒙脱石降低血尿酸的作用;用磷钨酸还原法测定尿酸含量。

Meanwhiles we measured the values of blood serum TC,TG,the results is hyperuricemia with hyperlipidemia incidence is high both in elder and control group,the incidence rates were 78.04%,85.71%respectively.

同时检测血甘油三酯TG、胆固醇TC发现高尿酸血症伴高脂血症的发生率在老年组和对照组中均较高,分别为78.04%和85.71%。

Uricase inhibitor was given subcutaneously by lanolin mixed with olefin in acute animal model with Hyperuricemia on rat, which has the characters of high uric acid and maintaining a long time.

以羊毛脂石蜡油(质量比3:2)为溶剂配制尿酸酶抑制剂,采用皮下注射的方法造模,所复制的大鼠代谢性高尿酸血症模型具有血尿酸值高、维持时间长的特点。

Objective:To investigate the influence of different contents of purines in diets on serum uric acid and its excretion in hyperuricemic elderly men.

目的:探讨不同嘌呤含量饮食对老年男性原发性高尿酸血症血尿酸及肾脏尿酸排出的影响。

It has been indicated from epidemiology and clinic research that hyperuricemia and hypertriglyceridemia are risk factors resulting in cardiovascular diseases. Even more, the foul-up of uric acid and triglyceride will aggravate cardiovascular or cerebrovascular diseases.

流行病学调查和临床研究表明,高尿酸血症和高甘油三酯血症是引发心血管疾病的危险因子,尿酸和甘油三酯交互紊乱更是诱发和加重心血管疾病的重要危险因素。

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