尿酸血症的

AIM To determine the optimal doses of hypoxanthine and uricase inhibitor oxonic acid potassium salt for establishment of hyperuricemia rat model, and provide experimental evidence to prepare continual hyperuricemia and gout animal model.

目的 确定次黄嘌呤与尿酸酶抑制剂氧嗪酸钾伍用制备高尿酸血症大鼠模型的合适剂量，为制备持续性高尿酸血症及痛风大鼠模型提供实验依据。

1hyperuricemia subjects have greater risk for high lipemia, high blood sugar,hypertension, artherosclerosis, obesity,and adomen-obesity. 2Beer was a risk factor, but hyperuricemia has not relation with education degree and smoking. 3To prevent and to therapia hyperuricemia need control weight,below blood pressure and lipemia., sufficient movement, blank diet, control drinking.

1高尿酸血症常伴发高血压病、动脉粥样硬化、高脂血症、高血糖、腹型肥胖。2啤酒是促进高尿酸血症发病的重要的危险因素，但文化程度、吸烟与血尿酸水平的相关性无统计学意义。3预防和治疗高尿酸血症必需控制体重、降低血压和血脂，适量运动，清淡饮食，控制饮酒。

In general,the recommendatory dose of 2 g/d is safe for human beings.This does not cause abnormal rise of serum uric acid level,which leads to hyperuricemia and gout.

饮食核酸可影响血尿酸水平；成人日补充量 2 g/d是安全的，不会引起血尿酸水平的异常持续性升高而产生高尿酸血症和痛风。

Objective:To study the inhibition of xanthine oxidase by renierol extracted from South China Sea sponge and study the influence of renierol on hyperuricemia in mice.

目的：本实验的目的是探讨中国南海海绵提取物renierol对黄嘌呤氧化酶的抑制作用及对小鼠高尿酸血症的影响。

Methods: Research on middle-aged and old person who hospitalized in our hospital from January, 2000 to October,2006, measure the blood uric acidwith zymology, the boundary is SUA which is bigger than 420mmol/l, Comparate and analysis the clinical material of hypeluricemia group, hypeluricemia merge coronary disease group and normal uric acid group.

以2000年1月至2006年10月在我院住院的中老年人为研究对象，采用酶学测定血尿酸，以SUA大于420mmol/l为界限，比较分析高尿酸血症组及高尿酸血症合并冠心病组与尿酸正常组的临床资料。

This paper is based on the previous pharmic effect reasearch to find the effective element decreasing the blood uric.

本课题在前期药效学确定的基础上进一步筛选其降低高尿酸血症的有效部位，以适应现代制剂的要求并为本品的开发奠定基础。

Aim To study the effect of acteoside of Scrophularia ningpoensis on the mouse hyperuricemia in vivo and its possible mechanisms.

目的 探讨玄参中苯丙素苷Acteoside对小鼠高尿酸血症的影响及可能的作用机理。

This is because:① hypertension caused by macrovascular disease, microvascular disease, the body part can hypoxia, blood lactate levels, leading to uric acid by inhibiting renal tubular secretion, coupled with increased synthesis of uric acid in patients, renal clearance of uric acid will reduce the functionality;② some long-term use in patients with hypertension Thiazide diuretics, the result of hypovolemia, which was repeated absorption of uric acid, thus leading to hyperuricemia.

这是因为：①高血压引起的大血管病变、微血管病变，可使机体部分组织缺氧、血乳酸水平升高，导致肾小管分泌尿酸受到抑制，加之病人体内尿酸合成增加，肾脏清除尿酸的功能就会降低；②部分高血压患者在长期使用噻嗪类利尿剂后，造成血容量减少，致使尿酸被重复吸收，从而引起高尿酸血症。

In addition, hyperlipidemia of kidney disease was also carried out to enable development, and hyperuricemia can be high blood pressure as an early indicator of renal damage, which means high blood pressure associated with hyperuricemia in turn increase the renal damage.

此外，高脂血症还可使肾脏病变呈进行性发展，而高尿酸血症则可作为高血压肾损害的早期指标，也就是说高血压伴发的高尿酸血症反过来又会加重肾损害。

Hyperuricemia of Uygur ethnicity was positively correlated with obesity and blood lipid concentration, the relationship between the level of serum uric acid and blood lipid concentration differs slightly in two sexualities, which shows more closely in male than in femal.

新疆维吾尔族人群高尿酸血症与肥胖、高脂血症密切相关，其中血尿酸水平与血脂的联系程度在不同性别间略有差异，男性TG、TC水平和血尿酸水平的联系较女性更为密切。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。