尿酸血症

Abstract］ objective to observe the effects of indapamide and losartan alone and combined treatment on the elder patients with hypertension,hypokalemia,hyperglycemia,uric acid,lipid,ect.methods one hundered and fifty patients with hypertension were randomly divided into three groups,with each of 50 cases.the levels of blood pressure,hypokalemia,blood sugar,uric acid,lipide were examined before and after treatment.results after 8 weeks the systolic and diastolic blood pressure were significantly lower.antihypertensive treatment group is the best,the levels of hypokalemia is lower after treatment in the indapamide group,the levels of uric acid is also lower in the losartan group and antihypertensive group.conclusion losartan and indapamide combined treatment not only coordinate to decrease blood pressure but also reduce uric acid,reduce the effect of hypokalemia caused by indapamide.

目的 观察氯沙坦与吲哒帕胺单独应用或联合用药对原发性高血压患者血压、血钾、血糖、尿酸、血脂的影响。方法将符合诊断标准的150例老年高血压患者电脑随机分为3组，每组50例，进行用药前后自身对照试验，8周后检测各组血压、血钾、血糖、尿酸、血脂值。结果 3组治疗后收缩压和舒张压均较前明显降低，联合治疗组降压幅度最大，氯沙坦组和联合治疗组治疗后尿酸值较治疗前降低，吲哒帕胺组治疗后血钾值较治疗前降低。结论氯沙坦与吲哒帕胺联合应用不仅具有协同降压作用，而且能降低尿酸，减轻吲哒帕胺引起的低钾血症。

Cheng Weili,Ding Mingmin,He Qiang,et al.The First Sanatorium of Jinan Military Aera,Qingdao266071. Objective To study the correlation of serum uric acidand lipid in the hyperlipidemia comˉplicated with hyperuricemia.

目的 检测高尿酸合并高脂血症患者血清尿酸、胆固醇、甘油三酯、高密度脂蛋白的含量，以了解其含量变化以及相互关系和影响。

Cheng Weili,Ding Mingmin,He Qiang,et al.The First Sanatorium of Jinan Military Aera,Qingdao266071. Objective To study the correlation of serum uric acidand lipid in the hyperlipidemia comˉplicated with hyperuricemia.Methods We measured UA and lipld by Bayer RA-1000automatic biochemical anaˉlyzer.

目的 检测高尿酸合并高脂血症患者血清尿酸、胆固醇、甘油三酯、高密度脂蛋白的含量，以了解其含量变化以及相互关系和影响方法采用Bayer公司的RA-1000型全自动生化分析仪和国产试剂盒进行测定。

MethodsSixty Wistar rats were divided into 2 groups randomly: normol group(n=12), and model group(n=48).The model rats were fed with high fat-sugar diet for 6 weeks, then fed with adenine(100 mg.kg-1.d-1) and ethambutol(250 mg.kg-1.d-1) for 2 weeks to induce the IR and hyperuricemia model.

方法选用 60只成年Wistar雄性大鼠，随机分成正常对照组（12只）和模型组（48只），模型组给予高脂高糖饲料喂养6周，6周后再用腺嘌呤〔100 mg/kg·d）〕加乙胺丁醇〔250 mg/〕灌胃2周，造成胰岛素抵抗并高尿酸血症的大鼠模型。

the hypeluricemia in middle and old-aged is related with coronary disease.

中老年高尿酸血症与冠心病相关。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。