尿酸血症

In recent years, as rapid development of economy, people living standard rises gradually, dietary structure is changed, the year after year of incidence of a disease of disease of acerbity blood of high make water rises, it is the common unusual index in check-up.

近年来，随着经济的快速发展，人民生活水平逐渐提高，饮食结构改变，高尿酸血症的发病率逐年上升，是体检中常见的异常指标。

Objective:To observe the process of high adenine diet causing hyperuricemia in wistar rats,and to make clear the effect of dietotherapy in disease prevention and control.

目的：观察wistar大鼠高嘌呤饮食诱发高尿酸血症的过程，明确饮食治疗在疾病预防和控制中的作用。

Because corticosteroid can modify the immunological process which is considered the major mechanism involved in AHS, it is used to treat AHS clinically. However, corticosteroid therapy may have deleterious effect (e.g., delayed healing of cutaneous lesions, infections, prolonged hospital stay). Therefore, the use of corticosteroids for AHS remains controversial. We reported a 54-year-old man who had underlying diabetes mellitus with chronic renal insufficiency, hypertension and hyperlipidemia. Allopurinol 100mg twice a day was initiated one month prior to admission. After taking the drug for 24 days, he developed a generalized mild itchy eruption on the trunk and upper extremities followed by chillness, fever, ocular discomfort and painful oral ulcer over one-week period and was admitted to the hospital. A skin biopsy revealed changes consistent with Stevens-Johnson syndrome.

本文报告一位54岁的男性患者，有高血压、高血脂、糖尿病及慢性肾脏功能不全的病史，最近发现有高尿酸血症(11.1mg/dL)而开始服用Allopurinol，在服用24日后，因为逐渐发生皮肤红疹搔痒、口腔溃疡、发烧、畏寒以及眼睛不适，一周之后到医院就医，经诊断为服用Allopurinol所造成之史帝文森－强生症候群(Stevens-Johnson syndrome)，因而在皮肤科住院接受治疗，由於病人有高血压、高血脂及糖尿病，所以入院后仅以支持疗法，并未给予全身性类固醇，然而病人之病况恶化，并有肾功能恶化，因而於住院两日后，转进肾脏科病房，在使用全身性类固醇治疗之后，病况持续改善，并在2周后出院。

Of the 8 cases, 2 cases showed blood Tb-Ab positive, 1 case was positive to antiacid bacillus of sputum, the rest cases with negative TBAb. 3 patients with 2 showed organs infection, 6 patients passed the tissue biopsy diagnose, body temperature of 6 cases fall to normal after 3-7 days of antituberculotic treatment, mild liver dysfunction appeared in 2 patients, hyperuricemia occurred in 7 patients, in addition, 1 patient developed reject reaction. Among all the cases, 7 cases healed, 1 died of pulmonary fungal infection.

其中2例血Tb-Ab，1例腹水结核抗体阳性，1例痰抗酸杆菌阳性，其余结核抗体阴性，3例患者表现为2个脏器感染，6例通过病理组织活检诊断，6例发热者在抗结核治疗3~7d体温降至正常，2例患者在治疗过程中出现轻度肝功能异常，7例出现高尿酸血症，1例出现移植肾排斥反应。8例患者7例痊愈，1例肺结核患者死于肺部真菌感染。6例发热者在抗结核治疗3~7d体温降至正常。

The level of serum uric acid and urinary uric acid were determined by phosphotungstic acid method.

目的 观察青秦液对高尿酸血症大鼠尿酸代谢及相关酶活性的影响。

Objective: To study the effects of treating uricacidemia and anti hypertension by losartan in elderly patients with hypertension associated hyperuricemia.

目的： 探讨氯沙坦对老年高血压伴高尿酸血症患者的降压和降尿酸作用。

Objective To study the content of uric acid in serum, to screen the uricemia patients, and to avoid the diseases caused by uricemia.

目的 了解中学生血清尿酸含量，以便尽早发现高尿酸血症患者，避免由此引起的疾病。

Detection of uric acid should be taken as one item of the physical examination, so as to serene uricemia and the related diseases in early.

将尿酸作为学生体格检查的项目有利于及时发现高尿酸血症及其相关疾病。

To warn that patients are receiving this medication at the same time not to use the excretion of uric acid can inhibit the antihypertensive drugs, such as Thiazide diuretics, including thiazide-type diuretics, as well as the compound preparation of salicylic acid drugs Astemizole aspirin, etc.

需提醒的是，患者在服用此药物的同时，不宜使用可抑制尿酸排泄的降压药物，如噻嗪类利尿剂、含噻嗪类利尿剂的复方制剂以及水杨酸类药物，以防止高尿酸血症的发生。

High levels of uric acid in the blood, called hyperuricaemia, can be caused by a diet high in purines or by impaired excretion by the kidneys.

高尿酸在血液中，称为高尿酸血症，可引起高的饮食嘌呤或排泄受损的肾脏。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。