尿酸血症

In part 1, a practical one-step RP-HPLC method thatcan simultaneous determine hypoxanthine, xanthine, uric acid, allantoin and creatinine in blood and urine was established.

人类高尿酸血症多为肾脏排泄尿酸减少的类型，而现有的建模方法在升高血尿酸的同时，也使尿尿酸含量显著增高。

AIM To determine the optimal doses of hypoxanthine and uricase inhibitor oxonic acid potassium salt for establishment of hyperuricemia rat model, and provide experimental evidence to prepare continual hyperuricemia and gout animal model.

目的 确定次黄嘌呤与尿酸酶抑制剂氧嗪酸钾伍用制备高尿酸血症大鼠模型的合适剂量，为制备持续性高尿酸血症及痛风大鼠模型提供实验依据。

Uygur national males have greater risk for the kidney harm, the high lipemia, the high blood sugar and the hypertension, should stregthern prevention and therapy.

维族男性高尿酸血症患者容易伴发肾损害、高脂血症、高血糖和高血压，应加强对高尿酸血症的防治。

1hyperuricemia subjects have greater risk for high lipemia, high blood sugar,hypertension, artherosclerosis, obesity,and adomen-obesity. 2Beer was a risk factor, but hyperuricemia has not relation with education degree and smoking. 3To prevent and to therapia hyperuricemia need control weight,below blood pressure and lipemia., sufficient movement, blank diet, control drinking.

1高尿酸血症常伴发高血压病、动脉粥样硬化、高脂血症、高血糖、腹型肥胖。2啤酒是促进高尿酸血症发病的重要的危险因素，但文化程度、吸烟与血尿酸水平的相关性无统计学意义。3预防和治疗高尿酸血症必需控制体重、降低血压和血脂，适量运动，清淡饮食，控制饮酒。

Methods: Research on middle-aged and old person who hospitalized in our hospital from January, 2000 to October,2006, measure the blood uric acidwith zymology, the boundary is SUA which is bigger than 420mmol/l, Comparate and analysis the clinical material of hypeluricemia group, hypeluricemia merge coronary disease group and normal uric acid group.

以2000年1月至2006年10月在我院住院的中老年人为研究对象，采用酶学测定血尿酸，以SUA大于420mmol/l为界限，比较分析高尿酸血症组及高尿酸血症合并冠心病组与尿酸正常组的临床资料。

The incidence rates of hyperlipemia,hypertension,diabetes,coronary heart discase,liver lipopexia in hyperuricemia group were sig-nificantely higher than that of normal group.

高尿酸血症组中高脂血症、高血压、高血糖、冠心病、脂肪肝等发生率显著高于血尿酸正常组。

Logistic regression analyses found tha tnationality, FINS, Hypertriglyceridemia, Hypercholesterolemia,BMI,serum Leptin, hypercholesterolemia, hypertriglyceridemia, low HDL cholesterol, diabetes, hypertension occupation, like drinking broth and chicken soup may be the risk factors ,and eating muscle, drinking milk, may be the protect factors of primar y hyperuricemia.

Logistic回归分析发现喜欢吃精瘦肉类和乳制品为高尿酸血症的保护因素，而患有高甘油三脂血症、胰岛素抵抗、高胆固醇血症、从事商业工作、高血压、喜欢喝肉汤鸡汤者以腰臀比较大、血清Leptin浓度较高可能是原发性高尿酸血症的危险因素。

This is because:① hypertension caused by macrovascular disease, microvascular disease, the body part can hypoxia, blood lactate levels, leading to uric acid by inhibiting renal tubular secretion, coupled with increased synthesis of uric acid in patients, renal clearance of uric acid will reduce the functionality;② some long-term use in patients with hypertension Thiazide diuretics, the result of hypovolemia, which was repeated absorption of uric acid, thus leading to hyperuricemia.

这是因为：①高血压引起的大血管病变、微血管病变，可使机体部分组织缺氧、血乳酸水平升高，导致肾小管分泌尿酸受到抑制，加之病人体内尿酸合成增加，肾脏清除尿酸的功能就会降低；②部分高血压患者在长期使用噻嗪类利尿剂后，造成血容量减少，致使尿酸被重复吸收，从而引起高尿酸血症。

In addition, hyperlipidemia of kidney disease was also carried out to enable development, and hyperuricemia can be high blood pressure as an early indicator of renal damage, which means high blood pressure associated with hyperuricemia in turn increase the renal damage.

此外，高脂血症还可使肾脏病变呈进行性发展，而高尿酸血症则可作为高血压肾损害的早期指标，也就是说高血压伴发的高尿酸血症反过来又会加重肾损害。

Hyperuricemia of Uygur ethnicity was positively correlated with obesity and blood lipid concentration, the relationship between the level of serum uric acid and blood lipid concentration differs slightly in two sexualities, which shows more closely in male than in femal.

新疆维吾尔族人群高尿酸血症与肥胖、高脂血症密切相关，其中血尿酸水平与血脂的联系程度在不同性别间略有差异，男性TG、TC水平和血尿酸水平的联系较女性更为密切。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。