尿酸尿

After two to three days of usage, the diuretic effects of this drug decline because of increased downstream reabsorption of ions and water by the renal tubules; however, the alkalinization of urine persists, and this basic urine attracts weak acids such as uric acid and cystine into the urine, thus increasing their urinary excretion.

在使用两到三天之后，这种药物利尿的效果会下降由于增加了下游肾小细管离子和水再吸收；然而，坚持碱化尿，而这种基本的吸收了弱酸例如尿酸和胱氨酸到尿里，因而增加了尿的排泄

Administration by gavage a mixture of melamine and cyanuric acid may produce insoluble melamine cyanurate crystals in kidney, which will block the tubules and cause renal damage and even acute renal failure. The melamine cyanurate crystals may form urinary calculi with uric acid and other components.

三聚氰胺和三聚氰酸联合灌胃大鼠的肾脏内会形成一种不溶于水的三聚氰胺氰尿酸盐晶体，堵塞肾小管造成肾脏损害甚至急性肾功能衰竭，并可能与尿酸等成分一起诱发泌尿系结石。

In part 1, a practical one-step RP-HPLC method thatcan simultaneous determine hypoxanthine, xanthine, uric acid, allantoin and creatinine in blood and urine was established.

人类高尿酸血症多为肾脏排泄尿酸减少的类型，而现有的建模方法在升高血尿酸的同时，也使尿尿酸含量显著增高。

The microscopic examinations of sediment demonstrated RBC urine in 46 cases (50%),RBC morphology was homogenerous type under the light microscope; WBC urine in 33 cases (35.9%), of which cultures for microorganism in 12 cases were all negative; crystal urine in 14 cases (15.2%), of which noncrystal type crystal was identified in 12 cases, while calcium oxalate crystal in 2 cases.

沉渣镜检：红细胞尿40例，占50%，普通光镜下观察红细胞形态为均一型。白细胞尿33例，占35.9%，干化学、沉渣镜检阳性符合23例，其中12例尿培养未检出致病菌。结晶尿14例，占15.2%，其中12例非晶型结晶有4例按混浊尿鉴别程序确定为非晶型尿酸盐结晶；另2例为草酸钙结晶。

Yiqi Huoxue Paishi decoction have certain effects in curing rats that intragastrically administrated with 1.25% Ethylene Alcohol plus 1% ammonia chloride, the mechanism is reducing the Ca(superscript 2+), Mg(superscript 2+), P(superscript 3+), uric acid of the blood serum and increasing the Ca(superscript 2+), Mg(superscript 2+), P(superscript 3+), uric acid of the urine.

益气活血排石饮对1.25%乙二醇合1%氯化铵接灌胃制作草酸钙结石大鼠模型有肯定的疗效，通过降低血清Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)、尿酸及肾组织草酸的含量以及增加尿Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)与尿尿酸的排泄，发挥该方的治疗作用。

Methods: Randomly subgrouping the rat into normal group, model group, paishi granule up, and Yiqi Huoxue Paishi decoction group, except the normal and model group, rats in other groups were all intragastrically administrated with 1.25% Ethylene Alcohol plus 1% ammonia chloride, then to observe the Ca(superscript 2+), Mg(superscript 2+), P(superscript 3+), uric acid of the blood serum and urine, the ethanedioic acid in renal tissue.

随机将大鼠分为正常组、模型组、排石冲剂对照组和益气活血排石饮组，除正常对照组外，以1.25%乙二醇合1%氯化铵灌胃制作大鼠草酸钙肾结石模型，观察各组大鼠血清Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)、尿酸及肾组织草酸以及尿Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)、与尿尿酸的含量。

The uricase is a kind of enzyme in the purine degeneration pathways of organism, the uric acid can be oxidated in allantoin, CO2 and H2O2, human does not have the uricase, therefore the uric acid accumulates in the vivo clinical organism such as the pathological change like gout.

摘要］ 尿酸酶是生物体内嘌呤降解代谢途径中一种酶，尿酸氧化生成尿囊素、CO2和H2O2，人体中没有尿酸酶，因此尿酸在体内的积累会出现临床机体的病变如痛风。

To warn that patients are receiving this medication at the same time not to use the excretion of uric acid can inhibit the antihypertensive drugs, such as Thiazide diuretics, including thiazide-type diuretics, as well as the compound preparation of salicylic acid drugs Astemizole aspirin, etc.

需提醒的是，患者在服用此药物的同时，不宜使用可抑制尿酸排泄的降压药物，如噻嗪类利尿剂、含噻嗪类利尿剂的复方制剂以及水杨酸类药物，以防止高尿酸血症的发生。

This is because:① hypertension caused by macrovascular disease, microvascular disease, the body part can hypoxia, blood lactate levels, leading to uric acid by inhibiting renal tubular secretion, coupled with increased synthesis of uric acid in patients, renal clearance of uric acid will reduce the functionality;② some long-term use in patients with hypertension Thiazide diuretics, the result of hypovolemia, which was repeated absorption of uric acid, thus leading to hyperuricemia.

这是因为：①高血压引起的大血管病变、微血管病变，可使机体部分组织缺氧、血乳酸水平升高，导致肾小管分泌尿酸受到抑制，加之病人体内尿酸合成增加，肾脏清除尿酸的功能就会降低；②部分高血压患者在长期使用噻嗪类利尿剂后，造成血容量减少，致使尿酸被重复吸收，从而引起高尿酸血症。

Objective: To investigate the effects of Yiqi Huoxue Paishi decoction in influencing Ca(superscript 2+), Mg(superscript 2+), P(superscript 3+), uric acid of the blood serum and the urine, and the ethanedioic acid in the renal tissue.

目的：探讨益气活血排石饮对肾结石大鼠血清Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)、尿酸及肾组织草酸以及尿Ca(上标 2+)、Mg(上标 2+)、P(上标 3+)与尿尿酸含量的影响。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。