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Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速,应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等,其中自杀基因被认为是最有前景的基因治疗方法,它又称病毒介导的酶/药物前体疗法,是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中,该基因表达的产物可将无毒的药物前体转化为毒性药物,从而选择性杀伤该肿瘤细胞,常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因,前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物,然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷,作为DNA合成链的终止剂和DNA合成酶的抑制剂,干扰细胞DNA的合成;后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶(5-FC)脱氨成为5-氟尿嘧啶(5-FU),然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸(5-FUTP)和5-氟-2′脱氧尿嘧啶-5′磷酸(5-FdUTP),5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成,5-FdUTP则作用于胸苷合成酶,导致TMP衰竭而阻止DNA的合成,最终诱导肿瘤细胞凋亡。

He noted that his urine had become 'bubbly' and red in color. He denied oliguria.

他自述他的尿液泡沫比较多而且颜色发红,但是并没有少尿现象。

Higter Piso than those with stable bladders, but the bladder capacity and the volume while feeling the first desire to void were decreased significantly in patients with detrusor instability than those with stable bladder.

再根据是否出现DI,把59例BPH病人分为不稳定膀胱组和稳定膀胱组,不稳定膀胱组的I-PSS、尿流加速度和Piso显著高于稳定膀胱组,初次尿液和膀胱最大容量显著低于稳定膀胱组。

Methods : 60 cases of chronic glomerulonephritis patients with the syndrome of water and heat combined ,were randomly divided into treatment group (30) treated by Compound Polyporus Umbellatus Decoction and control group (30) treated by Polyporus Umbellatus Decoction respectively for 3 months.

材料与方法:临床诊断为慢性肾炎阴虚水热互结证患者60例,作为研究对象,随机分成治疗组、对照组,每组各30例,治疗3个月后观察治疗前后尿蛋白、尿红细胞、血肌酐、血尿素氮、中医证候积分变化及总体疗效分析,用统计学分析两组间各项指标的差异。

Collect this unit to there was pathology consultation case to the place between July 2007 in January 2000, diagnose in 155 in be case of illness of polypous shape cystitis, discovery has 41 to be diagnosed to be road of tit shape make water by pathology doctor at first epithelial tumour is signed and issue at the report hind send toward this unit to have consultation below the requirement of urological department doctor.

收集本单位2000年1月至2007年7月间所有病理会诊病例,在155例诊断为息肉状膀胱炎病例中,发现有41例最初被病理医生诊断为乳头状尿路上皮肿瘤并于报告签发后在泌尿科医生的要求下送往本单位进行会诊。

CHF can suggest a possible prerenal cause secondary to reduced renal perfusion from a concomitant exacerbation in CHF or from diuresis with loop diuretics.

充血性心力衰竭是肾前性肾损害的一种潜在病因,即当CHF恶化或者应用髓袢利尿药大量利尿时,可能继发肾脏血流灌注不足。

The stavudine was prepared from 5-methyluridine via six steps in 34% overall yield, in which the key step is the selective acylation of 5-methyluridine by propionyl chloride.

该路线以5-甲基尿苷为起始原料,关键步骤是5-甲基尿苷和丙酰氯的选择性酰化反应,六步反应总收率为34%。

The approach to non-bacterial prostatitis and prostatodynia is several fold depending on what is believed to be the cause of the problem.

如果医生觉得是因为尿液倒流到膀胱,再进入前列腺,那么就要用减少尿液倒流的药物。

The ureteral stents were kept between 6 to 14 days.The types of ureteral stents were resinic ureteral ducts and doluble"J" ureteral ducts. Results:The data of 364 patients who went through pneumatic lithotripsy before June 2004 were studied retrospetively.

结果:2002年5月~2004年6月,术后未放置输尿管支架管的89例患者中, 42%(37/89)出现输尿管绞痛、感染、尿外渗、发热和无尿等并发症;2004年7月~2006年3月,所有患者术后均放置输尿管支架管,术后无一例出现并发症。

The results showed that the crystal, miscellaneous germs and saccharomycete were main factors of affectting the detected results by UF100 urine sediment analyzer.

讨论]为获得准确可靠的尿红细胞检验结果,应以UF100全自动尿沉渣分析仪进行筛查,并结合显微镜检查。

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The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了,排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意,我建议我们在价格上大家各让一半。

After an hour and no pup, look for continued contractions and arching of the back with no pup as a sign of trouble.

一个小时后,并没有任何的PUP ,寻找继续收缩和拱的背面没有任何的PUP作为一个注册的麻烦。