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To observe method of chick embryo allantois membrane, judge neovascularisation, research the effect of angiogenesis by drugs by means of chick embryo allantois membrane model.

学会观察鸡胚尿囊膜血管的方法,判断新生血管形成,通过鸡胚尿囊膜模型探讨药物对血管生成作用的影响

In lungs, AQP1 was abundant in peribronchiolar capillaries, postcapillary venules, bronchiolar basal membrane and alveolar epithelial cells.

结果表明,托吡酯在给药剂量范围内(0.068μg-6.8μg/鸡胚)可抑制鸡胚尿囊膜的血管生成,剂量为0.68μg/鸡胚和6.8μg/鸡胚时抑制效果明显,最高抑制率达33.5%。

OBJECTIVE: To investigate the effect of different combinations of the biomembrane on the chick embryo chorioallantoic membrane angiogenesis, and to find the best combination.

目的:探讨不同配伍的生物膜对鸡胚绒毛尿囊膜血管生成的影响,寻找最佳的组合方式。

The purified protein was detected by chicken chorioallantoic membrane angiogenesis inhibitory assay and endothelial cell proliferation inhibitory assay.

将纯化的蛋白质通过鸡胚尿囊膜血管生成抑制实验和内皮细胞抑制实验对纯化的蛋白质进行生物学活性测定。

The experiment research of angiogenes effect of Tongxinluo capsule on the chick embryo chorioallantoic membrane model[J].

部分冠心病常用中药对鸡胚尿囊膜的促血管生成作用研究[J]。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速,应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等,其中自杀基因被认为是最有前景的基因治疗方法,它又称病毒介导的酶/药物前体疗法,是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中,该基因表达的产物可将无毒的药物前体转化为毒性药物,从而选择性杀伤该肿瘤细胞,常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因,前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物,然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷,作为DNA合成链的终止剂和DNA合成酶的抑制剂,干扰细胞DNA的合成;后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶(5-FC)脱氨成为5-氟尿嘧啶(5-FU),然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸(5-FUTP)和5-氟-2′脱氧尿嘧啶-5′磷酸(5-FdUTP),5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成,5-FdUTP则作用于胸苷合成酶,导致TMP衰竭而阻止DNA的合成,最终诱导肿瘤细胞凋亡。

ABSTRACT:BACKGROUND To study the value of the urinary luteinizing hormonetest on the prediction of ovulation in infertile women.

摘要] [背景]探讨尿促黄体生成激素半定量试纸在不孕妇女排卵监测中的应用价值。

ABSTRACT:BACKGROUND To study the value of the urinary luteinizing hormonetest on the prediction of ovulation in infertile women.

探讨尿促黄体生成激素半定量试纸在不孕妇女排卵监测中的应用价值。

Methods The chemical hypoxia was induced by incubation of U251 cells with cobalt chloride.

以氯化钴模拟缺氧,采用RT-PCR、免疫细胞化学方法分别检测缺氧诱导因子-1α和血管内皮生长因子mRNA和蛋白的表达,鸡胚绒毛尿囊膜模型检测缺氧时胶质瘤细胞血管生成情况。

The thesis are divided into two parts. In the first part, we used 2,4,6-trichloro-1,3,5-triazine as the precursor to react with sodium which have been achieved by decomposing sodium hydrate at 623 K. At a low reaction temperature of 623 K, carbon nitride nanosphere、porous carbon nitride material and byproduct sodium chloride, would be produced.

本研究将分成两部份,第一部分是在低温下(623 K)将氢化钠粉末热裂解,生成表面积较大的熔融态金属钠,使气态的氰尿醯氯通入与熔融态金属钠在623 K反应,生成奈米氮化碳球、奈米孔洞性氮化碳材料及副产物氯化钠。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。