尿毒症的

Objective To investigate the effect of hemodialysis for uremic paticnts complicated with severe metabolic acidosis.

目的 观察血液透析抢救尿毒症伴严重代谢性酸中毒的疗效。

RESULTS: Bone histological examination showed predominant hyperparathyroid bone disease in 6 patients, mixed uremic osteodystrophy in 3 patients, low-turnover osteomalacia in 1 patient, and adynamic bone disease in 4 patients.

结果： 骨组织学检查的诊断出 6个患者有严重的骨组织形态学疾病，3个患者的混合尿毒症的骨发育不良，1个患者的低转动骨软化，和 4个患者的无力骨疾病。

Of the 60 patients, chronic nephritis 27 cases,acute serious nephritis 3 cases,essential hypertension 9 cases,diabetes 9 cases, multilocular cyst 6 cases,lupus nephritis 6 cases were enrolled. 60 CRF cases with four phase,including the phase of compensation of renal malfunction,the phase of no-compensation of renal insufficiency the phase of azotemia and the phase of renal failure,were divided into three groups.

CRF原发病为慢性肾炎27例、急进性肾炎3例、原发性高血压9例、糖尿病9例、多囊肾6例、狼疮肾6例，把这60例CRF患者根据中华内科杂志编委会肾脏病专业组于1992年6月在安徽太平举办的原发性肾小球疾病分型、治疗及疗效判定专题座谈会的标准分为四期第1期：肾功能不全代偿期、第2期：肾功能不全失代偿期、第3期：肾功能衰竭期、第4期：尿毒症期；本研究分为轻、中、重症（肾功能衰竭期及尿毒症期）3组来对照观察。

Objective To study the relationship between the apoptosis of lymphocytes and down-regulation of immunity in patients with uremia by examining the influence of serum of patients with uremia on apoptosis and expressions of Fas in cultured peripheral blood lymphocytes of healthy adult and the interventional function of VitE.

目的 通过观察尿毒症患者血清对培养的正常人淋巴细胞凋亡、Fas分子表达的影响以及VitE的干预作用，探讨淋巴细胞凋亡与尿毒症患者免疫功能低下的关系，并寻找防治对策。

Methods Using Western ligand blot technique, the authors measured plasma levels of IGFBP-1-4 in uremic acidotic rats and uremic but without acidotic rats, in the non-uremic acidotic and pair-fed rats and also delermined liver mRNA in UA and UB rats.

采用Western ligand blot等方法，对随意进食组、尿毒症酸中毒组及其对照组尿毒症未合并酸中毒组、非尿毒症酸中毒组及其对照组无酸中毒组的大白鼠进行了血清IGFBP-1-4的测定，对UA、UB组肝脏IGFBPs mRNA进行了测定。

As uremic sicken rate year after year grows, dialytic technology also perfects the blood that replaces remedy as the kidney increasingly, make of uremic patient live time also is lengthened stage by stage, live quality gets rising, but the death that all sorts of reasons cause also occurs ceaselessly.

梗概： 随着尿毒症患病率逐年增长，做为肾脏替代治疗的血液透析技术也日益完善，使尿毒症患者的生存时间也逐步延长，生存质量得到提高，但各种原因导致的死亡也不断发生。

For example, blood urea concentration as an accurate measure of kidney function and the concept of extrarenal azotemia were first reported at that time.19 It was then believed that the kidney expended considerable energy to excrete urea into the urine and that moderate restriction of protein was beneficial to human patients as contended by Addis.20 This concept fell out of favor in human medicine when it was realized that renal work is tied closely to active sodium reabsorption and that urea is passively handled.

举例来说，血中尿素浓度依照肾脏功能的准确测量和肾外尿毒症的概念都是在当时第一次揭露。19而那时大家相信肾脏花费相当多能量以分泌尿素到尿液里，然而Addis主张适当限制蛋白质的摄取，是有益於患者。20这个观点赞同人类服用的药物上使用，当肾功能被积极钠紧密连接重新吸收，而尿素却是处於被动控制。

objective to investigate the existence of the erythropoiesis inhibitors.methods the present study included twelve undialyzed esrd patients with anemia.the sera from the uremic patients were added to cfu-e and bfu-e culture in the concentrations ranging from 1.25% to 5%.in vitro cfu-e and bfu-e growth in the presence of sera from esrd patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.results the effects of the sera from uremic patients on cfu-e and bfu-e colony growth in concentrations ranging from 1.25% to 5% were investigated to be dose-dependent.the effect increased with the concentrations increasing of the sera（p＜0.05）.there were not significant inhibitory effect on the cfu-e and bfu-e growth of mice bone marrow in vitro from sera of the normal subjects.conclusion the erythropoiesis inhibitors exist in uremic sera which has a dose-dependent inhibitive effects on the growth cfu-e and bfu-e of normal mice bone marrow cells.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。结果在实验组中，与血清浓度为0的浓度组相比，与各浓度组血清共同培养的小鼠骨髓cfu-e和bfu-e的集落数均明显减少，且随血清浓度的增加，小鼠骨髓cfu-e和bfu-e的集落数逐渐减少，各浓度组间差异有显著性（p＜0.05）。结论尿毒症患者血清抑制小鼠骨髓红系祖细胞集落形成，随患者血清浓度的增加，抑制作用增强，具有剂量依赖性。

To selected 36 uremic patients who were treated in the blood purification center and kidney medical department of the Fourth hospital of Hebei medical university from January to October in 2006, which included 18 uremic patients who were treated with hemodialysis and 18 uremic patients who weren't dialyzed.

选取2006年1月至2006年10月在河北医科大学第四医院血液净化中心及肾内科治疗的尿毒症患者36例，其中常规血液透析的尿毒症患者18例，非透析的尿毒症患者18例。

It pushes Chinese drugs forward to the modernization actively to create the new medicine with China's Project 1035,the first kind of new broad-spectrum anticarcinogen-Huaidingjian Hydrochloride Injection;and that of the drugs-Gengnianxin Capsules used to cure climacteric syndrone;It also assumed China's High-Tech Industrial Demonstration Project,the new major product of the nation Level-Urotoxic Excretory Powder used to cure uraemia and took on a series of other national important science and technology schemes.It has realized the changes from scientific and technological predominance to industrial and dimensional ones.

承担并完成了国家1035工程项目，广谱抗癌一类新药——盐酸槐定碱注射液，和用于治疗更年期综合症的更年欣胶囊，以及国家高技术产业化示范工程，用于治疗尿毒症的国家级重点新产品——尿毒排析散等一系列国家重大科技项目，实现了科技优势向产业优势和规模优势的转变。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。