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Temporarily catheterization pulls out inside 24 H ureter, if undertake uric education or acute retention of urine wait,adopt temporarily catheterization; leaves buy catheterization to be in clinical on common, ureter needs to leave above of buy 24 H, urethral mouth is daily want clean disinfection 2 times, daily change 1 times; keeps bag of collect make water or drainage bottle the person that buy catheter exceeds 7d, change every week ureter 1, with 0 · normally according to the circumstance of fluid of eduction make water 9% physiological saline undertake bladder is rinsed. 2 common problems patient of a few males is opposite circumstance of the psychogenic disorder when 1 catheterization of 2 · nurse catheterization produces psychogenic disorder, often be flushed, next abdomen and perineal ministry muscle are nervous, shadow fugleman make water goes on wheels, impact of urgenter to the illness patient psychogenic disorder is not big, ache and bladder are bouffant the mood that held them, catheterization process is more successful. 2 · 2 see the phenomenon is cracked below road junction of female patient make water occasionally 20 old clinical nurse in the job, the female cracks a circumstance to see 4 below urethral mouth.

临时导尿在24 h内拔除尿管，如进行尿培养或急性尿潴留等采取临时导尿；留置导尿在临床上常见，尿管需留置24 h以上，尿道口每日要清洁消毒2次，每日更换集尿袋或引流瓶1次；留置导尿管超过7d者，每周更换尿管1次，根据排出尿液的情况通常以0·9%生理盐水进行膀胱冲洗。2常见新问题2·1导尿时心理障碍情况一些男性患者对护士导尿产生心理障碍，往往面红耳赤，下腹部及会阴部肌肉紧张，影响导尿顺利进行，对于病情较急的患者心理障碍影响不大，疼痛和膀胱鼓胀占据了他们的情绪，导尿过程较顺利。2·2偶见女性患者尿道口下裂现象20多年的临床护理工作中，女性尿道口下裂情况见4例。

Furthermore, compared with the tautomerizing processes of uracil, the probability of 5-FU to tautomerize to its enol form is much higher. Based on such facts, the reason why 5-FU is an effective anticancer medicament but with some of toxicity is explained to some extent.

通过与尿嘧啶质子转移过程相比较，发现在各种情况下5-氟尿嘧啶异构化为烯醇式的几率均比尿嘧啶的大，在一定程度上解释了为什么5-氟尿嘧啶具有优良抗癌作用的同时具有一定的毒副作用。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

In the normal uterus, Cytokeratins immunolabelling were detected in glandular cell, luminal epithelial cell, Vimentin immunolabelling were detected in stromal cell and endoblastic cell; CK7 immunolabelling were not detected in any tissue of the yak utenus.

研究结果显示：未妊娠时，泛角蛋白在子宫内膜腺上皮细胞、腔上皮细胞内表达，波形蛋白在子宫内膜基质细胞内表达，平滑肌肌动蛋白在子宫平滑肌和血管平滑肌内表达，牦牛子宫任何部位均不表达角蛋白7；妊娠30天左右时，泛角蛋白在子宫内膜腺上皮细胞、子宫内膜腔上皮细胞、滋养层细胞、内胚层细胞和尿囊细胞内表达，波形蛋白在子宫内膜基质细胞和内胚层细胞内表达，平滑肌肌动蛋白在子宫平滑肌和血管平滑肌内表达，角蛋白7在尿囊细胞内表达，偶尔在腔上皮细胞的细胞核边缘表达；消化法进行原代培养时，组织经胶原酶消化并通过100目和400目筛网组合可以有效地分离原代子宫内膜基质细胞和子宫内膜腺上皮细胞；分离得到的子宫内膜基质细胞活率达90%以上，并可在体外传代7次以上；分离得到的子宫内膜腺上皮细胞活率可达85%以上，并可在体外传代5次以上；RPMI1640培养基最适合子宫内膜基质细胞和子宫内膜腺上皮细胞的生长，维持子宫内膜基质细胞正常生长的FBS添加量为20%，维持子宫内膜腺上皮细胞正常生长的胎牛血清添加量为30%。

Conclusion1 Critically ill patients with indwelling catheters were of the high positive rate of microorganisms,and microorganism spectrum was of special properties;BF formed mainly inside the catheter,the occurrence rate of BF inside the catheter was high and the formation time was short;Changes on catheters and the result of microorganisms was positively correlated with the BF formation.2 Indwelling catheter time was the independent risk factors for the BF formatiom, while age、APACHEⅡscore、sex、urine sugar and the types of antibiotic usage were the potential risk factors for the BF formation;Nurses should perfect the catheter measures for critical ill patients,emphasis on the assessment of risk factors of BF formation,and implement special care in high-risk patients.3 In the early stage of BF formation,irrigation could play the role of eradicative BF effectively;While later,it couldn't,but it can delay the speed of BF formation and maturation;In the choice of washing methods,injection type washing method is superior to infusion.

结论1重危患者留置尿管微生物培养阳性率高，且微生物菌谱具有特殊性；重危患者尿管表面BF主要在尿管内壁形成；内壁BF的发生率高，形成时间短；肉眼观察尿管表面改变情况以及微生物鉴定结果与BF形成呈正相关。2尿管留置时间是重危患者留置尿管表面BF形成的独立危险因素；年龄、APAcHEⅡ评分、性别、尿糖定性以及抗生素使用种类是其可能的危险因素；护理过程中应完善重危患者尿管护理措施，注重对BF危险因素的评估，并对高危患者实施重点护理。3 BF形成早期，冲洗能发挥较好的清除作用；BF形成后期，冲洗无法彻底清除尿管表面BF，但冲洗能延缓BF形成与成熟的速度；在冲洗方式的选择上，注洗式冲洗法对尿管BF的清除效果优于输注式冲洗法。

Theurinary IL-6 level positively correlated with density of glomerular matrix membrane, global sclerosis, fiber or fibrocellular crescents and interstitial fibrosis (p. 05). According to the degree of density of glomerular matrix membrane and interstitial fibrosis, urinary Col-IV level had better correlation than urinary TGF-betal and IL-6 levels.In IgAN, Col-IV showed increased expression in diseased renal tissue whereas the site of expression of TGF-betal was mainly localized within the cytoplasm of tubular epithelial cells. Interstial expressionwas also present but glomerular TGF-betal expression was found only in patients with heavy mesangial proliferation. There was a significant correlation between glomerular positivity for Col-IV and severity of histological damage. There was also a significant correlation between positivity for TGF-betal and Col-IV in the tubular epithelial and interstitial lesions. In contrast, there was no ralationship between glomerular positivity for TGF-betal and severity of histological damage.The urinary TGF-betal level paralleled tubular TGF-betal expression.

结果 ①IgAN患者尿TGF-β1、IL-6、Col-Ⅳ水平较健康人明显增高(P＜0.01)，该变化与血中的浓度无关(P＞0.05)；②尿TGF-β1水平与小管间质TGF-β1阳性表达呈正相关(P=0.000)，而与小球TGF-β1阳性表达无关(P＞0.05)，尿Col-Ⅳ水平与小球和小管间质Col-Ⅳ阳性表达均呈良好的相关性(P＜0.01)，还与小管间质TGF-β1阳性表达呈正相关(P＜0.05)：③小球Col-Ⅳ阳性表达与肾组织慢性病变密切相关(P＜0.05)，小管间质Col-Ⅳ和TGF-β1阳性表达均与肾小管间质病变呈良好的相关性(P＜0.01)，而小球TGF-β1阳性表达与肾组织损伤无关(P＞0.05)；④尿TGF-β1、Col-Ⅳ水平与肾小球基质基底膜面密度、小管间质病变呈正相关(P＜0.01)，与小球内细胞数呈负相关(P＜0.05)，该结果与其在组织中的表达一致；尿IL-6水平浙江大学硕士学位论文尿TGF一B一、IL一6和Col一IV在IgA肾病中的应用价值与基质基底膜面密度、球性硬化、纤维或细胞纤维新月体所占肾小球百分数及小管间质病变均有显著的相关性(F.05)；在轻度肾病理损伤时，尿'l'G卜pl、I卜6、Col一IV水平即升高，而尿Col一W在反映细胞外基质积聚和间质纤维化程度上比尿TGF一pl和IL一6有更好的相关性。

Compound Danshen Injection combined with Anisodamine can improve microcirculation cooperatively. Using the combined therapy to treat IgAN patients of this type can improve hypercogulabity state, hemorhelogy and microcirculation disorders. The combined therapy can reduce the excreation of urinary erythrocyte and protein, and decrease serum IgA. The curative effects of the combined therapy overmatches using western medicine of control group.

复方丹参联合654-2在改善微循环方面具有协同作用，用于治疗以血尿为主要表现的IgAN能有效改善患者的高凝高粘状态、血液流变性异常及微循环障碍，明显减少尿红细胞及尿蛋白的排泄，降低血清IgA水平，在一定程度上优于对照组西药的疗效。

This may be explained by follows: First, Decoction Shenkangling can regulate the homeostasis of NEI network and reduce the increased activity of NF-κB to restrain the action of inflammatory-sclerotic media; Second, it can redress the disequilibrium of the ratio of TXA2/PGI2 to reform the hypercoagulable state; Third, it can enhance albumin and reduce cholesterol and triglyceride; Fourth, it can amend the renal damage and protect the function of renal tubule and stroma to prevent the transformation from MCD to FSGS; Last, it can lessen urine protein in AN rats markedly and relieve the side effects of prednisone.4. NF-κB, TXA2 and PGI2, along with the renal pathomorphology and so on can all be the indexes of the diagnosis of Symptom of "Kidney Deficiency and Blood Stasis" and the application of Methods of "Benefiting the kidney and Promoting blood circulation" in TCM.5. The curative effects on AN rats by treatment of integrating Traditional Chinese Medicine with prednisone are much better than using prednisone only. And the curative effects on AN rats by treatment of matching Decoction Shenkangling, having the function of "Benefiting the kidney and Promoting blood circulation", with Prednisone are much better than using Prednisone only.6. When it referred to decreasing urine protein, cholesterol and triglyceride and increasing albumin, Decoction Zhibodihuang excesses Decoction Taohongsiwu. However, when it referred to regulating the disequilibrium of TXA2/PGI2 and meliorating renal lesion, Decoction Taohongsiwu exceeds Decoction Zhibodihuang.7. The curative effects on AN rats by treatment of matching Methods of "Benefiting the kidney and Promoting blood circulation" with Prednisone overmatches using Prednisone matching Method of "Benefiting the kidney" or Method of " Promoting blood circulation" only.

益肾活血中药肾康灵能显著改善AN鼠的肾虚血瘀证的临床表现和实验指标，这可能与中药肾康灵能调理AN鼠机体的NEI网络功能稳态，降低异常升高的NF-κB活性，抑制免疫炎症/硬化介质环节，纠正失衡的TXA2/PGI2，改善AN鼠血液高凝状态，提高AN鼠的血清Alb，降低Ch和TG，减轻AN鼠的肾脏组织病理学变化，保护肾小管－间质功能，阻止MCD向FSGS转化；显著减轻AN鼠的尿蛋白水平以及减轻激素副作用有关。4、NF-κB、 TXB2和6-keto-PGF1α以及肾脏病理形态学改变等，都可作为中医肾虚血瘀证诊断和益肾活血法应用的客观指标。5、中西医结合干预AN鼠疗效优于单纯激素治疗；强的松配合益肾活血中药肾康灵组的综合疗效显著优于单纯强的松组。6、知柏地黄汤组在降低尿蛋白、提高血清Alb、降低Ch和TG疗效上优于桃红四物汤组；桃红四物汤组在纠正失衡的TXA2/PGI2和减轻肾脏病理损害方面优于知柏地黄汤组。7、激素配合益肾活血法干预AN鼠在一定程度上优于激素配合益肾法或活血法。

Tri- sodium citrate with aqueous gold chloride were warmed up and mixed to make gold sol; The chicken IgG(anti-JG04 strain GPMV) was immobilized to a defined detection zone on a porous nitrocellulose membrane, while 3A_5 was conjugated to colloidal gold which served as a detection reagent.

在加样处沾取含有GPMV的尿囊液样品，GPMV与金标3A_5结合形成混合液，由于层析原理，混合液向上移动，在检测线上混和液中与金标颗粒结合的GPMV与鸡IgG结合，由于大量GPMV沉积在检测线上，出现红线；而如果尿囊液中不含有GPMV，检测线上不出现红线。

My daughter is one year old summer night without diapers, I put a chair beside the bed, the toilet seat on a small chair, every night she will wake up the middle of the night, and then take her to the urinary uric Toilet .

宝宝一周岁正好是夏天，晚上不用尿不湿，我在床边放了一个椅子，把小坐便器放在椅子上，每天晚上都会半夜叫醒她，然后抱她去坐便器上尿尿。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。