尿嘧啶

Results After many times oral administration of Jiangtangning capsules(40～600mg/kg),the blood glucose of hyperglycemic mice,rats and rabbits induced by adrenaline,glucose,streptozotocin and alloxan was decreased obviously,and had significant dose-effect relationship,the symptoms of polydipsa,polyphagia and polyuria were improved for alloxan-induced hyperglycemic mice and rats,meanwhile the release of insulin in alloxan-induced hyperglycemic mice serum was promoted,but having no apparent influence on the normal blood glucose of mice.

结果 在40～600mg/kg剂量下，多次灌服降糖宁胶囊对肾上腺素、葡萄糖、链脲佐菌素和四氧嘧啶引起的小鼠和大鼠以及家兔高血糖均有明显的降低作用，且有明显的量效关系，还可明显改善四氧嘧啶性高血糖小鼠和大鼠多饮、多食、多尿等三多症状，并可促进四氧嘧啶性高血糖小鼠血清中胰岛素的释放。但对小鼠正常血糖却无明显影响。

Drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole.

抗甲状腺？药物（他巴唑，甲基硫氧嘧啶，丙基硫氧和硫氧嘧啶）；一些镇静剂（doxylamine琥珀和苯巴比妥），以及包括系统性真菌抗生素灰黄霉素，安体舒通的利尿一些其他药物，以及抗菌磺胺类药物和磺胺二甲嘧啶。

Neomycin on ammonia acid can lead to vitamin B12 deficiency; phenytoin, methotrexate, B ammonia pyrimidine, methyl benzyl ammonium pyrimidine and Triamterene, etc. can cause folic acid deficiency; mercaptopurine, 5 - fluoro-piperidine urine density, Ara-C, etc. can interfere with nucleic acid synthesis, these drugs can lead to megaloblastic anemia.

新霉素、对氨水杨酸可导致维生素B12缺乏；苯妥英钠、甲氨蝶呤、乙氨嘧啶、甲基苄氨嘧啶及氨苯蝶啶等可引起叶酸缺乏；巯嘌呤、5--氟尿密啶、阿糖胞苷等能够干扰核酸的合成，这些药物都可导致巨幼红细胞性贫血。

Three organic compounds containing nitrogen have been isolated fTom soft coral Sarcophyton Molle Collected from South China Sea. Their structures have been determined by UV, IR, MS, 1H NMR and 13C NMR as sinumeramide Thymine and Thympidine.

从中国南海软珊瑚中分离到三个含氮化合物，其结构经紫外光谱、红外光谱、质谱和核磁共振（1HNMR、13CNMR）分析分别确定为神经酰胺Sinumeramide，胸腺嘧啶和脱氧尿核嘧啶苷。

UCK is able to catalyze phosphorylation of its physiological substrate uridine and cytidine, and it also plays important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer, such as 6-azauridine, 5-fluorouridine and so on.

将表达UCK不同丰度的肝癌细胞进行6-氮尿苷的敏感试验显示，6-氮尿苷对UCK表达量较高的HepG2细胞的毒性作用强于对UCK表达量较低的L02细胞，提示UCK有可能成为临床用药的一个参考指标，克隆人类尿苷胞苷激酶对寻找新的嘧啶核苷类似物并研究它们的药理活性有着重要的意义。

By incorporation of tritiated thymidine or 5-bromodeoxyuridine and using them as the markers, we found that the basal cells, Clara cells and type II alveolar epithelial cells in the pulmonary tissues may in some way behave like stem cells and can eventually differentiate into respiratory tract epithelium.

通过应用cells in induced group cultured for 2 weeks 标记的胸腺嘧啶(3H-TdR)或5-溴脱氧尿核苷的渗入进行标记，发现肺组织的基底细胞、Clara 细胞和肺泡II型上皮细胞可能具有干细胞特征，能最终分化形成气道上皮。

By incorporation of tritiated thymidine or 5-bromodeoxyuridine and using them as the markers, we found that the basal cells, Clara cells and type Ⅱ alveolar epithelial cells in the pulmonary tissues may in some way behave like stem cells and can eventually differentiate into respiratory tract epithelium.

通过应用cells in induced group cultured for 2 weeks von kossa staining）标记的胸腺嘧啶(3H-TdR或5-溴脱氧尿核苷的渗入进行标记，发现肺组织的基底细胞、clara细胞和肺泡Ⅱ型上皮细胞可能具有干细胞特征，能最终分化形成气道上皮。

Heating, ethanol precipitation, and ion-exchange chromatographies had been carried out to isolate the protein with specific stimulating activity from newborn calf liver, and [(3)H]thymidine deoxyribose/bromodeoxyuridine incorporation and carboxyfluorescein diacetate succinimidyl ester-based proliferation assay to determine the bioactivity in vitro and in vivo.

通过用加热、乙醇沉淀、离子交换层析等方法来分离新生小牛肝脏中含有特殊刺激活性的蛋白和用胸嘧啶脱氧核糖/溴脱氧尿苷联合羧基荧光素双乙酸钠琥珀酸酯为基础的扩增分析其体内和体外的生物活性。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。