尼古丁

Jean Nicot, the Frenchman who gave his name to nicotine, believed that he had discovered a miracle drug.

让·尼古丁，这个给尼古丁命名的法国人，相信他发现了一种神奇的药物。

Jean Nicot, the Frenchman who gave his title to nicotine, believed those he had discovered a miracle drug.

让·尼古丁，那个给尼古丁命名的法chinese，相信他呈现了一种神奇的药品。

The aim of the present study was to study the effect of nicotine on ghrelin and the growth hormone secretagogue receptor expression, the effect of ghrelin on vascular cell adhesion molecule-1(VCAM-1) and interleukin-8 (IL-8) expression in nicotine incubated human umbilical vein endothelial cell,and the possible signaling transduction mechanisms associated with PKC, p38 MAPK and NF-κB.

本实验通过观察ghrelin对尼古丁所致HUVEC VCAM-1及IL-8表达变化过程中PKC、p38 MAPK及NF-κ3的活性变化，并应用PKC、p38 MAPK及NF-κB的特异性抑制剂chelerytherine chloride、SB203580、PDTC，探讨ghrelin阻断尼古丁引起内皮细胞功能紊乱致AS作用的信号转导机制。

Surgeon General has confirmed that nicotine in tobacco products has addictive properties similar in severity to those of heroin.

尼古丁 美国医学联合会证明烟草产品中的尼古丁有类似于海洛因致人上瘾的性质。

Meanwhile, the Iron Goddess of Mercy of caffeine can enhance liver metabolism of drugs, promote blood circulation to the body of nicotine in the blood from the urine excretion, reduce and eliminate the side effects of nicotine.

同时，铁观音中的咖啡碱能提高肝脏对药物的代谢能力，促进血液循环，把人体血液中的尼古丁从小便排泄出去，减轻和消除尼古丁带来的副作用。

To explore the influence on the expression of orexin A in the hypothalamus and orexin type 1 receptor (OX1R) in the medulla of neonatal rats after prenatal nicotine exposure, the 20 pregnant rats were divided into 2 groups randomly. Either nicotine (6 mg/kg per day) or normal saline solution (as same volume as nicotine group) was administered into the pregnant rats hypodermically from the fifth day to the end of gestation.

为了观察出生前尼古丁暴露对新生大鼠下丘脑orexin A及延髓内orexin 1型受体（OX1R）表达的影响，本实验将20只雌性成年大鼠随机均分为二组，怀孕后第5 d开始每天分别皮下注射尼古丁6 mg/kg或等量的生理盐水，直至分娩。

In chapter 2 of this dissertation, a highly efficient synthesis of the title compound: 1-methyl-2, 3, 3a, 4, 5, 9b-hexahydro-1H-pyrrolo [3, 2-h] isoquinoline (157), a conformationally constrained nicotine analog, has been accomplished in only seven steps starting from commercially available 3-bromopyridine.

在第二章中，我们对具有刚性构象的尼古丁类似物的合成进行了研究。医学研究表明，尼古丁及其类似物对许多神经系统类疾病具有很好的治疗效果，而且药理活性与分子的构象有着非常密切的关系，许多具有刚性构象的分子有着很强的药理活性。

Methods Number of microglia treated with different doses of nicotine and GM-CSF was determined by MTT assay.

培养的小胶质细胞系(BV-2)中加入不同浓度的尼古丁或尼古丁与粒细胞巨噬细胞集落刺激因子，用MTT方法检测细胞活性，观察对小胶质细胞数量的影响。

The measurement of nicotine and its major metabolites cotinine and trans-3 -hydroxicotinine together with other minor metabolites (e.g., cotinine N-oxide, cotinine, and trans-3 -hydroxicotinine glucuronides) in conventional and nonconventional biological matrices has been used as a biomarker to assess the exposure to environmental tobacco smoke during childhood.

常规和非常规性生物基质内尼古丁、尼古丁主要代谢产物可替宁和反式-3-羟基可替宁及其他代谢产物（可替宁N-氧化物，可替宁和反式-3 –羟基可替宁葡萄糖苷酸）的检测可作为评价儿童期环境烟草烟雾暴露的一个生物标志物。

The UV/vis exhibited the absorbance of BSA(210nm) to shift tored and decrease gradually with the addition of nicotine, reflecting the transition of secondarystructure of BSA, namely the helix of BSA become looser.

Lineweaver-Burk 双倒数方程计算pH7.4 和 pH11.0 体系在温度为 20℃和 37℃条件下尼古丁和 BSA 的结合常数 k 分别为： k20℃=140.15 L·mol-1 ，k37℃=131.83 L·mol-1 （pH7.4）和 k20℃=141.76 L·mol-1，k20℃=27.79L·mol-1(pH11.0)，表明结合常数在 pH7.4 条件下受温度的影响要比 pH11.0 条件下小，推测是由于不同 pH 下尼古丁存在的不同形态所致。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。