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Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果:新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用;对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用,且在相同剂量下,外涂给药和ig给药的作用无明显差异。

Methods Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti- inflammatory action of CSC. Its acute toxicity in mice was also evaluated.

方法]采用细菌脂多糖致家兔发热、啤酒酵母致大鼠发热动物模型,观察穿心莲软胶囊的解热作用;采用角叉菜胶致大鼠足肿胀、二甲苯致小鼠耳肿胀和醋酸致小鼠腹腔毛细血管通透性增加的动物模型,观察穿心莲软胶囊的抗炎作用,并对小鼠进行该制剂的急性毒性试验。

the analgesic effect of water decoction of caulis spatholobi was observed by mice writhing test, mice tail-immersion test and hot-plate test,with three concentrations (25%,50% and 100%).

采用小鼠热板法、小鼠醋酸扭体法和小鼠热水缩尾法观察25%、50%和100%三种浓度的鸡血藤水煎液的镇痛作用。

Ovoalbumin-induced rat feet edema was significantly decreased by QLS with the doses of 35 and 70.0 mg·kg-1·d-1 (P.05).Cotton pellet-induced rat granuloma was significantly decreased by QLS with the doses of 35.0 and 70.0 mg·kg-1·d-1 (P.05 or P.01 ) and the granuloma inhibitory rates were 32.40 % and 35.65 %,respectively.

结果:QLS 3个剂量组均不同程度地抑制小鼠耳肿胀度,与空白对照组比较,50及100 mg·kg-1·d-1 QLS组小鼠耳肿胀度均明显减小(P.05或P.01),对小鼠耳肿胀的抑制率分别为53.97%和60.09%;QLS 35.0及70.0 mg·kg-1·d-1组均显著抑制大鼠足肿胀(P.05),且对棉球所致肉芽组织增生有明显的抑制作用(P.05或P.01),大鼠肉芽肿的抑制率分别为32.40 %和35.65 %。

METHODSThe auricle inflammation models were made with xylene and croton oil to investigate the effects of Purslane extracton auricel swelling in mice.The acetic acid twisting body test and the hotplate test were used for the study of analgesic effects of the ethyl acetate extract in mice.

方法]采用二甲苯及巴豆油致小鼠耳廓炎症的方法,观察马齿苋提取物对小鼠耳廓肿胀度的影响;采用扭体法和热板法,观察对小鼠镇痛作用的影响。

ResultsXue Dan Wei Chang pill could reduce the areas of gastric ulcer caused by absolute alcohol in mice and acetic acid in rats,inhibit the auricle swelling caused by croton oil in mice and the number of stretching induced by acetic acid in mice.

结果雪胆胃肠丸均能使小鼠无水乙醇所致胃溃疡的溃疡面积明显减小,能降低大鼠溃疡指数,可降低醋酸致小鼠扭体反应的次数,抑制巴豆油致小鼠耳廓肿胀。

MethodsThe model of cerebral ischemia and anoxia in mice was established by decollation and ligating common bicarotid artery the effect of BVF on the survival time of the mice,and the time of catching their breath after mice decollated,and mouse brain capillary vessel permeability were observed.

方法采用小鼠断头、结扎双侧颈总动脉等脑缺血缺氧模型,观察苦菜总黄酮对脑缺血缺氧小鼠存活时间、断头小鼠喘息时间及脑毛细血管通透的影响;TBA法、NBT法测定小鼠脑缺血缺氧后脑组织MDA含量和SOD活性。

Methods The model of cerebral ischemia and anoxia in mice was established by decollation and ligating common bicarotid artery the effect of BVF on the survival time of the mice,and the time of catching their breath after mice decollated,and mouse brain capillary vessel permeability were observed.

采用小鼠断头、结扎双侧颈总动脉等脑缺血缺氧模型,观察苦菜总黄酮对脑缺血缺氧小鼠存活时间、断头小鼠喘息时间及脑毛细血管通透的

Methods The model of cerebral ischemia and anoxia in mice was established by decollation and ligating common bicarotid artery the effect of BVF on the survival time of the mice,and the time of catching their breath after mice decollated,and mouse brain capillary vessel permeability were observed. The content of maiondialdehyde,activity of superoxide dismutasein the brain tissues of cerebral ischemia and anoxia mice were measured by TBA,NBT technology respectively.

采用小鼠断头、结扎双侧颈总动脉等脑缺血缺氧模型,观察苦菜总黄酮对脑缺血缺氧小鼠存活时间、断头小鼠喘息时间及脑毛细血管通透的影响;TBA法、NBT法测定小鼠脑缺血缺氧后脑组织MDA含量和SOD活性。

Results: Shukang granule can obviously resist inflammation induced by dimethylbenzene, egg-white, raise the pain range of mice induced by hot plate , extend the delitescence of mice's turn-body reaction induced by injecting potassium antimony tartrate and decrease the number of times in 10min, restrain the meat-bud of rats formed.

结果:术康颗粒可明显抑制二甲苯所致小鼠耳廓肿胀和大鼠蛋清性足趾肿胀,明显提高小鼠热板法致痛的痛阈,使酒石酸锑钾所致小鼠扭体反应的潜伏期延长,10min内扭体次数减少,对大鼠棉球肉芽肿形成有抑制作用。

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