小鼠

Mice from MixTx group were transplanted with mouse islets and NICC admix grafts in the left kidney and NICC grafts in the right kidney. Only normoglycemic mice were undergoing the subsequent macrophage challenge.

1胰岛移植与巨噬细胞重建：STZ诱导的糖尿病NODSCID小鼠分别接受：Balb／c小鼠的胰岛移植，混合移植(左侧接受小鼠胰岛与NICC的混合移植物，右肾接受NICC异种重建后移植物)和NICC异种移植。

CFB has the function of falling blood sugar on alloxan diabetic rats or mice and hyperglycaemia mice induced by adrenine and exogenous glucose.

CFB对四氧嘧啶致糖尿病大鼠或小鼠、肾上腺素血糖升高小鼠及外源性葡萄糖致血糖升高小鼠具有明显降血糖作用。

MethodsRats were divided into two groups: control group and experimental group. The rats' thymus index, production of their serum agglutinin and macrophoge's phagocytic function were tested.

方法将小鼠随机分成空白对照组和复方大枣口服液组，通过对小鼠胸腺指数、血清凝集素产生及巨噬细胞吞噬机能的试验，观察口服液对小鼠免疫机能的影响。

Methods Observation on the anti-inflammatory effects of 11-sodium deoxyglycyrrhetinic acid in three models i.e. induced mice's ear swelling, chronic granuloma by filter paper and air sac synovitis. The NOS activity and contents of PGE2 in mice serum and inflammatory humour were measured.

通过二甲苯致小鼠耳片肿胀、纸片致小鼠慢性肉芽肿及气囊性滑膜炎3个模型观察11-脱氧甘草次酸钠的抗炎作用，并测定小鼠血清和炎症液中前列腺素E2(PGE2)的含量和一氧化氮合酶活性。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The expressions of thedifferentially expressed genes (gamma-A-crystallin and neural tropomodulin) werefurther analyzed in the retinae of rds, rd and C3B mice using real-time quantitativeRT-PCR assay. Based on the sequence of ESTs from the differential display, thefull-length genes were amplified using the RACE method.

实验方法：以生后第12天、第25天和第37天为研究时段，应用mRNA差异显示与cDNA表达阵列等方法分析rds小鼠发病过程中视网膜差别表达的基因，然后用Northern blotting和实时荧光定量PCR等方法，分析差别基因在rds小鼠和rd小鼠视网膜的表达，所分析的时间为小鼠整个生命周期。

To investigate the effect of EPO on hepcidin mRNA expression in normal mice,acute inflammatory mice and ACD mice,the acute phase model and ACD model of mouse was produced by subcutaneous injection of turpentine oil.

本研究探讨红细胞生成素在正常小鼠、急性炎症小鼠和慢性病性贫血小鼠模型中对hepcidin mRNA表达的影响。通过小鼠背部皮下双肩胛骨间脂肪垫内注射松节油的方法建立急性炎症模型和ACD模型。

Those mice developed younger-looking skin that was about as thick as the skin of a newborn mouse.

这些实验老年小鼠的皮肤看起来像年轻小鼠，实验小鼠皮肤的厚度像新生小鼠皮肤厚度。

Here, we show that mice genetically deficient in Toll-like receptor 5 (TLR5), a component of the innate immune system that is expressed in the gut mucosa and that helps defend against infection, exhibit hyperphagia and develop hallmark features of metabolic syndrome, including hyperlipidemia, hypertension, insulin resistance, and increased adiposity.

但美国Emory University的Matam Vijay-Kumar和Gewirtz等人在前人研究的基础上，意外的发现TLR5（Toll样受体-5）缺陷的小鼠较正常小鼠重20%，而且血甘油三酯、血胆固醇、血压及血糖偏高。TLR5缺陷的小鼠比正常小鼠进食多10%，经限制饮食后前者体重下降，但同时对胰岛素的反应下降；在经高脂饮食后前者体重快速增加并表现出&糖尿病&和&代谢综合征&表现。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。