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The course will start with an overview of the central and peripheral nervous systems, the development of their structure and major divisions. The major functional components of the CNS will then be reviewed individually. Topography, functional distribution of nerve cell bodies, ascending and descending tracts in the spinal cord. Brainstem organization and functional components, including cranial nerve nuclei, ascending / descending pathways, amine-containing cells, structure and information flow in the cerebellar and vestibular systems. Distribution of the cranial nerves, resolution of their skeletal and branchial arch components. Functional divisions of the Diencephalon and Telencephalon. The course will then continue with how these various CNS pieces and parts work together.

这门课将会从中枢和周边神经系统构造的发展和主要的分化点来概述,中枢神经系统的主要功能将会在复习中个别地说明:神经细胞体的断层以及功能性的分布、脊髓内上升和下降神经束的特征学和功能分布;脑干组织和功能要素,包括脑神经核、上升和下降神经束走向、含胺基酸脑激素细胞的分布、小脑和内耳前庭系统的构造和资讯传导流;颅神经的分布、骨弓和腮弓的演化;间脑和终脑的功能与分类;这门课将会探讨这些不同的中枢神经系统如何一起作用。

To explore the function of PDE in canine central nerve , gene expression of 18 PDE subtypes in different fractions of canine central nerve (cerebrum,cerebellum,myelencephalon and spinal cord) were detected by RT-PCR,and PDE activity was calculated by the content changes of cyclic nucleotides before and after the PDE reaction examined by high performance liquid chromatography.

为探明磷酸二酯酶(phosphodiesterase,PDE)在犬中枢神经活动中的作用,采用反转录聚合酶链反应检测18个PDE亚型在犬中枢神经不同部位中(大脑、小脑、延髓和脊髓各段)的表达分布,以高效液相色谱法检测环核苷酸在酶反应前后的含量变化,计算PDE活性。

Objective To construct spinocerebellar ataxia 3 (SCA3) eukarotic expression vector with en hanced green fluorescent protein as report gene and to observe its expression in PC12 cells.

目的 构建以增强型绿色荧光蛋白作为报告基因、带有脊髓小脑性共济失调3型(SCA3)基因的真核细胞表达载体,并转染PC12细胞,观察外源基因的表达情况。

In the brain stem,there were very dense orexin B immunoreactive fibers in the superior colliculus,inferior colliculus,interpeduncular nucleus,dorsal raphe nucleus and central gray.

此外,在小脑、脊髓和垂体柄及垂体后叶也有少量的阳性纤维的分布。

Objective To screen for proteins interacting with ataxin-3 by yeast two-hybrid system 3, and to discuss the function of ataxin-3 and pathogenesis of spinocerebellar ataxia type 3 and Machado-Joseph disease (SCA3/MJD).

目的:利用酵母双杂交系统3筛选与ataxin-3相互作用的蛋白质,探讨ataxin-3的功能和脊髓小脑型共济失调Ⅲ型(SCA3/MJD)的发病机制。

This dorama is about a girl who was diagnosed with a disease called Spinocerebellar Degeneration when she was 15 years old, and was able to continue her life until her death at the age of 25 years old.

从小就是好学生乖宝宝的亚也考上了自己心仪的高中,原以为从此光辉灿烂快乐的人生正等着自己,没想到却患上了不治之症——脊髓小脑变性症。

Spinocerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders.

第一部分 SCA家系致病基因定位第一章一个新的SCA家系致病基因定位脊髓小脑型共济失调(spinocerebellar ataxias,SCA)是一种具有高度临床和遗传异质性的神经系统退行性疾病,多呈常染色体显性遗传。

Objective Machado-Joseph disease/Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by an expansion of polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3. The precise mechanism of the MJD/SCA3 pathogenesis remains unclear.

目的 马查多-约瑟夫病/脊髓小脑共济失调3型,是由 MJD1基因产物ataxin-3的C-末端的多聚谷氨酰胺发生重复扩展突变而引起的一种常染色体显性遗传的神经退行性疾病,目前它的发病机制还不清楚。

Results:① Neuroglobin-immunocreactive positive cells were detected in cortex, thalamencephalon, hippocampus, hypothalamus, cerebellum, brain stem and spinal cord;② Ngb-IR positive nerve cells were also detected in peripheral nervous system such as intramural ganglia, myelinated nerve fiber and retina;?Substantial Ngb protein expression was also found in metabolically active endocrine tissues such as the pituitary gland , adrenal gland and testis.?

结果:(1)在所观察的大脑皮质、海马、丘脑、下丘脑、脑干、小脑和脊髓神经细胞都出现Ngb蛋白免疫阳性反应,不同区域表达强度不同:(2)在外周神经系统的神经节、有髓神经纤维和视网膜也观察到Ngb免疫阳性反应;(3)垂体、肾上腺、睾丸也可见到Ngb-IR阳性细胞。

Usually these are found in the subcortical and central white matter and cortical gray-white junction of both cerebral hemispheres , cerebellum , brainstem , and spinal cord [11] , but periventricular white matter and gray matter of the cortex , thalami and basal ganglia may also be involved.

通常,这些被发现的皮质和中央白质和皮质灰色白色双方交界处的大脑半球,小脑,脑干和脊髓[ 11 ] ,但周围白质和灰质的皮质,丘脑和基底节也可参与。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

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