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Objective To explore SCA3 gene mutation in the patients with inherited spinocerebellar ataxia.

目的 探讨遗传性脊髓小脑型共济失调病人SCA3基因突变的意义。

Objective To study the gene mutation of the spinocerebellar ataxia(SCA types 1~3 in the patients with primary dystonia.

目的 研究原发性肌张力障碍患者脊髓小脑性共济失调1~3型基因的突变。

PTEN immuno-positive reactive products were extensively distributed in CNS of adult rat, including telencephalon, cerebrum, diencephalon, brainstem, cerebellum, and spinal cord.

PTEN阳性反应产物广泛分布于大鼠的CNS内,包括端脑、大脑、间脑、脑干、小脑和脊髓。

Neuronal cell bodies and fibers with moderate mGluR7-LI were seen in the olfactory bulb,anterior olfactory nucleus,piriform cortex,septofimbrial nucleus,bed nucleus of the strial terminalis,lateral hypothalamic area,paraventricular hypothalamic nucleus,supramammillary nucleus,medial and lateral mammillary nuclei,most part of the thalamus,medial and lateral geniculate bodies,nucleus of the optic tract,red nucleus,substantia nigra,interpeduncular nucleus,pontine nuclei,lateral parabrachial nucleus,superior olivary complex,nucleus of the trapezoid body,motor nucleus of the trigeminal nerve,facial nucleus,ambiguus nucleus,cochlear nucleus,vestibular nuclei,nucleus of the solitary tract,hypoglossal nucleus,prepositus hypoglossal nucleus,medullary reticular formation,Purkinje cells of the cerebellum,nucleus raphe obscurus,intermediolateral nucleus of the spinal cord,Onuf′s nucleus and lamina X of the spinal cord.

呈中等强度染色的神经元胞体和纤维见于嗅结节、前嗅核、梨状皮质、隔伞核、终纹床核、下丘脑外侧区、下丘脑室旁核、乳头体上核、乳头体内、外核、丘脑大部分核团、内外侧膝状体、视束核、红核、黑质、脚间核、桥核、臂旁外侧核、上橄榄复合体、斜方体核、三叉神经运动核、面神经核、疑核、耳蜗核、前庭核簇、楔束外核、孤束核、舌下神经核、舌下神经前置核、中缝隐核、延髓网状结构、小脑蒲肯野细胞层、脊髓中间带外侧核、Onuf核和中央管周围灰质。

The brain stem lesions observed on MRI were most commonly at the tegmentum of the pons (18/25, 72%) followed by the medulla oblongata (15/25, 60%), and the midbrain which includes the tegmentum, substantia nigra and superior cerebellar peduncles (11/25, 44%).

二十五例在急性期接受磁振造影检查的病童中,有十八例发现在脑干和上颈脊髓有T2高讯号病灶,病灶发现频率依序分别为:桥脑(18/25,72%),延脑(15/25,60%),中脑(包括脑盖,黑质区和上小脑脚)(11/25,44%)。

Spinal cord. Locomotion. Oculomotor control. Cerebellar structure and function.

脊髓,运动,眼球运动的支配,小脑构造和功能。

Objective To study the gene mutation characteristics of patients with spinocerebellar ataxias in Ningxia region.

目的 研究宁夏地区脊髓小脑性共济失调患者基因突变的特征。

Objective To determine the frequency of different subtypes of spinocerebellar ataxias in the Han nationality of Hunan province in China.

目的:研究湖南汉族人群中脊髓小脑性共济失调不同基因亚型的分布状况。

We investigated the clinical features and gene mutation in a pedigree of spinocerebellar ataxia.

对一脊髓小脑性共济失调(Spinocerebenllar ataxia, SCA)家系的患者进行临床特征及相关基因突变研究。

Spinocerebellar ataxia type 7 (SCA7) is less variable in clinical presentation than other SCAs.

脊髓小脑性共济失调7型(SCA7)的临床表现形式较其它SCA类型少。

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