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In addition, PTEN was detected in rat spinal cord and cerebellar granular cells cultured in vitro. It was also extensively expressed in many sites of adult mouse brain, including olfactory bulb, cortex, basal forebrain, hippocampus, amygdaloid body, and cerebellum.

此外在大鼠脊髓、体外培养的小脑颗粒细胞,以及成年小鼠嗅球、大脑皮层、基底前脑、海马、杏仁体、小脑都可以观察到PTEN的表达,提示PTEN在中枢神经系统(Central nervous system, CNS)中具有重要作用。

These DSs were first observed at 9 weeks in the distal part of ascending fibers that consist of gracile fasciculus and cerebellospinal-gracile nucleus and white matter of cerebellum. They extend along medulla oblongate to medulla cervix、medulla thorax、medulla lumbalis in accordance with dying-back type degeneration. The corticospinal tract were affected at 18 weeks,and thalamus、the olfactory pathway、the visal pathway、the auditory pathway were affected at 32 weeks.

这种DS从9周龄开始,首先在构成薄束路和脊髓小脑后路的上行纤维的远端区域-薄束核区和小脑白质出现,逐渐按照延髓、颈髓、胸髓、腰髓的顺序,向细胞体方向逆行性地进展。18周龄时波及到锥体路,32周龄时进一步波及到丘脑和嗅觉、视觉、听觉传导路。

The fibres of the corticospinal tract, which run craniocaudally in the dorsal pons, the pontine tegmentum, and the superior cerebellar peduncles ventrally, were all preserved, this differential involvement therefore being responsible for the cruciform appearance on MRI.

译:脑桥神经元和横桥纤维严重减少,造成脑桥基底部和小脑中脚的苍白和萎缩。上下走行于脑桥背侧的皮质脊髓束、脑桥背盖部、腹前侧的小脑上脚/结合臂均未受累。这种差异性受累是MRI上出现十字征的原因。

Typical signs and symptoms: affection of white matter transduction bundle of spinal cord, optic nerve, periventriclular white matter, brain stem and cerebella .

典型的症状和体征:脊髓的白质传导束、视神经、脑室周围白质、脑干和小脑的病变。

The cell from hippocampus, striatum, ependyma, thalamus opticus, olfactory bulb, cortex, brain stem, cerebellum, and spinal cord in human fetal brain were studied using HE staining and immunocytochemistry.

应用HE染色和免疫细胞化学方法观察人胎脑室管膜下区、海马、纹状体、丘脑、嗅球、皮层、脑干、小脑、脊髓的Nestin阳性细胞。

Of the 26 lesions with pontine and bulbar involvement, three had no association with other lesions (Fig 2). Twelve were associated with tegmental and superior cerebellar peduncular extension, and six showed corticospinal tract involvement in continuity with an MDJ lesion. In one patient with additional telencephalic lesions, the right side of the pons was hyperintense on long TR/TE images that did not cross the midline, suggestive of an arterial lesion (Fig 3). In two patients with pontine tegmental lesions, there was an associated middle cerebellar peduncle and deep cerebellar white matter involvement (Fig 4). Two others had associated cervical lesions.

在26处脑桥延髓区病灶中,3处病灶仅限于脑桥延髓区,其它部位无病灶(图2);12处病灶还同时伴有背盖部和小脑上脚/结合臂处病灶;6处病灶为与中脑-间脑接合处病灶相连的皮质脊髓束受累;还有1例患者除端脑见病灶外,右侧脑桥于T2像也见高信号病灶,但未超越正中线,提示可能系动脉病变所致(图3);2例脑桥背盖部病灶的患者同时伴有小脑中脚/小脑脑桥脚和小脑深部白质受累(图4);还有2处脑桥延髓区病灶还同时伴有颈髓病灶。

Spinocerebellar ataxias are a group of autosomal dominant cerebellar degenerative disorders, which are characterized by clinical and genetic variability.

脊髓小脑性共济失调是一组常染色体显性的小脑退行性病,具有临床和遗传多样性。

Machado-Joseph disease is an autosomal dominant spinocerebellar degeneration characterized by a wide range of clinical manifestations.

Machado-Joseph 疾病是晚发性的体染色体显性遗传疾病,一种小脑脊髓渐进性神经退化性疾病,此疾病的徵状在临床上变化很多,显现范围很广。

The studies were of predictive genetic testing for Huntington's disease, hereditary breast and ovarian cancer, familial adenomatous polyposis and spinocerebellar ataxia.

这些文献进行的研究包括了,杭丁顿氏症、遗传性乳癌及卵巢癌、家族性大肠腺肿症、小脑脊髓萎缩症等疾病之预报性遗传检验。

Conversely, injury to the reticulospinal or vestibulospinal tracts, which normally inhibit spinal reflex pathways, results in "positive" symptoms including spasticity, hyperactive muscle stretch reflexes, abnormal cutaneous and autonomic reflexes, and co-contraction of agonist and antagonist muscles.

相反,一般不影响脊髓反射通路的皮质脊髓束和小脑脊髓束的损伤导致阳性效应,包括痉挛、牵张反射亢进、病理的皮肤反射和自主反射、相互拮抗肌的共同紧张。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

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